Apoptosis, proliferation and p53 gene expression of H. pylori associated gastric epithelial lesions

Table 1 Effect of H. pylori infection on AI in gastric epithelium (%, mean ± SD)

Group	H. pylori positive		H. pylori negative
	n	AI	n	AI
Normal	-	-	20	2.08 ± 1.07
Metaplasia	15	4.36 ± 1.95d	15	3.81 ± 1.76
Dysplasia	15	2.31 ± 1.10b	15	3.05 ± 1.29
Carcinoma	10	1.34 ± 0.69a	10	1.89 ± 1.03

^dP < 0.01, vs normal (H. pylori negative);

^aP < 0.05,

^bP < 0.01, vs upper adjacent group.

Table 2 Effect of H. pylori infection on PI in gastric epit helium (%, mean ± SD)

Group	H. pylori positive		H. pylori negative
	n	PI	n	PI
Normal	-	-	20	9.78 ± 3.65
Metaplasia	15	19.11 ± 6.79e	15	12.25 ± 5.63d
Dysplasia	15	33.89 ± 11.65eb	15	22.09 ± 8.18d
Carcinoma	10	48.27 ± 15.67ea	10	34.70 ± 12.74c

^eP < 0.01, vs normal (H. pylori negative);

^aP < 0.05,

^bP < 0.01, vs upper adjacent group;

^cP < 0.05,

^dP < 0.01, vs positive group.

Table 3 Effect of H. pylori infecion on expression of p53 protein in gastric epithelium

Group	n	H. pylori	n	p53 positive n (%)
Normal	20		20	0 (0.0)
Metaplasia	30	+	15	7 (46.7)b
		-	15	1 (6.7)
Dysplasia	30	+	15	8 (53.3)
		-	15	5 (33.3)
Carcinoma	20	+	10	8 (80.0)
		-	10	7 (70.0)

^bP < 0.01, vs normal (H. pylori negative).