Dysfunction of peripheral blood dendritic cells from patients with chronic hepatitis B virus infection

Table 1 Clinical background of HBV-infected patients and healthy donors

Group	n	Gender M/F	Age (years)	ALT (nkat·L-1)	AST (nkat·L-1)	HBV DNA	HBsAg	Anti-HBs	HBeAg	Anti-HBe	Anti-HBc
Patients	20	17/3	29.5 (12-47)	215 ± 218	186 ± 172	19	18	—	16	4	20
Donors	10	8/2	27.5 (20-35)	20-40	20-40	—	—	6	—	—	—

—: Nagative results

Table 2 Comparison of expression of DC surface markers from CHB patients and healthy donors (number fraction, x^-± s)

Group	n	B7-1 (CD80)	B7-2 (CD86)	CD1a	HLA-DR
CHB-DC	20	0.44 ± 0.08	0.44 ± 0.08	0.25 ± 0.07	0.46 ± 0.09
Normal-DC	10	0.88 ± 0.10b	0.84 ± 0.09b	0.89 ± 0.09b	0.92 ± 0.09b

^bP < 0.001 vs CHB-DC.

Table 3 Spontaneous cytokine production in pure DCs population and AMLR (x^-± s, ng·L^-1)

Dendritic cell	Supernatant from MLR culture		Supernatant from pure DCs population (ng·L-1)
	IL-12 (ng·L-1)	IL-10 (ng·L-1)
CH-B	27 ± 4	18 ± 7	99 ± 51
Normal	86 ± 32b	25 ± 9	218 ± 104b

^bP < 0.01, vs Normal.