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©The Author(s) 2000.
World J Gastroenterol. Aug 15, 2000; 6(4): 613-618
Published online Aug 15, 2000. doi: 10.3748/wjg.v6.i4.613
Published online Aug 15, 2000. doi: 10.3748/wjg.v6.i4.613
Formation of NMU | ||||
Amount of NaNO2(μmol) | Concentration (μmol/L) | Total amount (μmole) | ||
in vivo | in vivo | in vivo | in vivo | |
3480 | 25.40 | 29.20 | 4.27 | 1.75 |
870 | 7.97 | 6.48 | 1.91 | 0.38 |
220 | ND | 2.77 | ND | 0.17 |
Table 2 Status of gastric juice samples from four human volunteers and formation of NMU 30 min after taking 40 mL of diluted fish sauce and 500 μmol of nitrite[9]
Sample’s origin | Total volume of sample (mL) | pH of sample | Total amount of NMU detected in gastric lumen (nmol) |
Male A | 24 | 5.0 | 4 |
Male B | 110 | 3.0 | 85 |
Female A | 50 | 2.0 | 100 |
Female B | 50 | 2.0 | 22 |
Table 3 Relationship between presence of total N-nitrosamides in gastric juice samples from subjects with pathological changes in gastric mucosa
Gastric mucosal status | Positive rate of total N-nitrosamides in gastric juice samples (%)** | ||
High risk areas | Low risk area | ||
Putian[13] | Linqu[28] | Cangshan[28] | |
*N and CSG | 2/12 (16.7) | 1/4 (25.0) | 4/23 (17.4) |
CAG | 10/14 (71.4)b | 38/76 (50.0)c | 18/56 (32.1) |
CAG and IM | 12/13 (92.3) | 17/56 (28.8)e | 0/4 (0.0) |
CAG and DYS 12/13 (92.3) | 18/44 (40.9) | 5/10 (50.0) |
Table 4 Presence of total N-nitrosamides (NAD) in gastric juice samples (GJ) from low and high risk areas for stomach cancer
High risk area (Linqu) | Low risk area (Chongshan) | P-value | |
No. of GJ samples | 176 | 99 | |
Proportion, pH ≤ 3 | 48.0% | 84.0% | < 0.01 |
pH ≥ 5 | 45.3% | 13.5% | < 0.01 |
Positive rate, all | 40.9% | 30.3% | = 0.03* |
GJ, pH ≤ 3 | 46.2% | 27.4% | < 0.01 |
GJ, pH ≥ 5 | 43.3% | 53.9% | |
Conc. (μmol/L) | 0.91 | 0.73 |
- Citation: Deng DJ. Progress of gastric cancer etiology: N-nitrosamides 1999s. World J Gastroenterol 2000; 6(4): 613-618
- URL: https://www.wjgnet.com/1007-9327/full/v6/i4/613.htm
- DOI: https://dx.doi.org/10.3748/wjg.v6.i4.613