Effects of Fuzheng Huayu 319 recipe on liver fibrosis in chronic hepatitis B

Table 1 The main symptoms and signs before and after treatment (cases)

Group	n		Fatigue	Anorexia	Abdominal flatulence	Nausea	Yellow urine	Yellow eye	Hypochondriac pain
Treated	63	Before	34	20	21	13	16	21	21
		After	1	1	1	1	3	3	4
Control	32	Before	24	10	9	12	6	9	10
		After	1	1	1	0	1	2	1

Table 2 Serum fibrotic markers in patients with Chronic hepatitis B

Group	MAO(u)	TIMP	P-III-P	IV-C	HA	LM(ng/mL)
Normal people	28 ± 13	164 ± 20	0.31 ± 0.12	99 ± 23	38 ± 36	234 ± 69
	(20)	(20)	(15)	(60)	(60)	(60)
Chronic hepatitis	63 ± 29d	192 ± 39d	1.41 ± 2.19b	494 ± 300d	362 ± 235d	358 ± 64d
B	(37)	(42)	(34)	(46)	(61)	(61)

^bP < 0.01,

^dP < 0.001, vs control. ( ) inside number was patient cases.

Table 3 The serum fibrotic markers and urinary hydroxyproline (^-x±s)

Group		MAO(U)	TIMP	P-III-P	IV-C	HA	LN(ng/mL )	Urine Hyp
	Cases	30	24	20	29	44	42	29
	Before	64 ± 30	184 ± 58	1.81 ± 3.9	547 ± 345	377 ± 293	369 ± 73	21.6 ± 8.9
Treated	After	28 ± 16d	153 ± 54b	0.80 ± 1.69a	386 ± 212b	210 ± 241d	208 ± 85d	24.5 ± 7.8a
	Difference	36 ± 27c	31 ± 44	1.01 ± 2.08	161 ± 262	167 ± 199	161 ± 116	3.2 ± 7.5
	Cases	7	18	14	17	17	17	17
	Before	60 ± 30	204 ± 59	1.57 ± 1.46	404 ± 179	356 ± 313	382 ± 68	20.7 ± 7.3
Control	After	47 ± 33	139 ± 39d	1.71 ± 3.14	333 ± 150a	220 ± 218a	282 ± 103d	22.6 ± 5.6
	Difference	13 ± 14	65 ± 47	0.14 ± 2.51	72 ± 121	136 ± 251	99 ± 92	2.0 ± 6.5

^aP < 0.05,

^bP < 0.01,

^dP < 0.001, vs before treatment.

^cP < 0.05 vs control.

Table 4 The liver inflammatory grades and fibrotic stages

	Inflammatory grades					Fibrotic stages
	G0	G1	G2	G3	G4	S0	S1	S2	S3	S4
Before treatment	0	1	7	3	1	1	1	3	5	2
After treatment	1	2	7	1	1	3	5	1	2	1a

^aP < 0.05, vs after before treatment.