Reversing effect of Tanshinone on malignant phenotypes of human hepatocarcinoma cell line

Table 1 Effect of Tan on BrdU labeling rate and PCNA positive rate of SMMC-7721 cells

Groups	BrdU labeling rate (%)	P	PCNA positive rate (%)	P
Control	28.0		74.3
Tan	8.9	< 0.01	57.0	< 0.01
ATRA	13.6	< 0.01		< 0.01
		< 0.01	47.6	> 0.05a

^aTan compared with ATRA group by χ² test.

Table 2 Effect of Tan on cell cycle and gene expression of SMMC-7721 cells

Groups	Distribution of cell cycle (%)			Labeling rate of gene expression (%)
	G0/G1	S	G2 + M	c-myc	c-fos
Control	47.7	16.2	36.1	23.8	25.9
Tan	57.6b	8.9b	33.5b	14.6b	41.7b
ATRA	59.5b	8.2b	32.3b	13.4b	28.5a

^aP < 0.05, vs control group;

^bP < 0.01, vs control group.