Extramural venous invasion in gastric cancer: 9.4T magnetic resonance imaging assessment and circular RNA functional analysis

Table 1 Differentially expressed circular RNAs between extramural venous invasion positive and negative samples

circRNAs	Gene name	log2FC	FC	P value	q value	CPM for EMVI positive group	CPM for EMVI negative group
hsa_circ_0058218	ARPC2	3.951	15.469	0.019	0.526	7.976	4.025
hsa_circ_0057109	PDK1	3.140	8.818	0.033	0.571	8.282	5.141
hsa_circ_0082335	KLHDC10	3.103	8.595	0.035	0.571	8.228	5.124
hsa_circ_0097977	ATF7IP	3.066	8.373	0.033	0.571	8.261	5.195
hsa_circ_0000283	CSTF3	3.027	8.150	0.012	0.526	8.767	5.740
hsa_circ_0007813	DHTKD1	2.719	6.584	0.007	0.463	9.244	6.525
hsa_circ_0006760	PRUNE	-4.573	0.042	0.003	0.345	4.025	8.598
hsa_circ_0027857	ACTR6	-3.120	0.115	0.005	0.389	5.737	8.857
hsa_circ_0002387	TNIK	-2.977	0.127	0.000	0.104	7.248	10.224
hsa_circ_0071185	LRBA	-2.370	0.193	0.031	0.571	6.639	9.009
hsa_circ_0005882	STK39	-2.303	0.203	0.005	0.389	7.380	9.683

circRNA: Circular RNA; EMVI: Extramural venous invasion; FC: Fold change; CPM: Counts per million.

Table 2 Differences of cell function test results between the knockdown and negative control groups

	BGC-823	MKN-74	NCI-N87
Apoptosis assay
Apoptotic cells (%)	P = 0.020	P = 0.010	P = 0.005
Transwell invasion assay
Cells per field	P = 0.001	P = 0.002	P = 0.025
Cell proliferation assay
OD450-24 hours	P = 0.722	P = 0.043	P < 0.001
OD450-48 hours	P = 0.075	P < 0.001	P < 0.001
OD450-72 hours	P = 0.020	P < 0.001	P = 0.010
OD450/fold-24 hours	P = 0.966	P = 0.124	P < 0.001
OD450/fold-48 hours	P = 0.433	P < 0.001	P < 0.001
OD450/fold-72 hours	P = 0.197	P < 0.001	P = 0.088

OD: Optical density.