Bibliometrics analysis based on the Web of Science: Current trends and perspective of gastric organoid during 2010-2023

Table 1 The top 15 most cited scholars in gastric organoid field

Rank	Author	Publications	Citations	Country	Centrality
1	Clevers, Hans	30	5144	Netherland	0.08
2	Huch, Meritxell	10	3987	German	0.04
3	Van es, Johan	7	3244	Netherland	0.00
4	Van de Wetering, Marc	6	3175	Netherland	0.00
5	Sato, Toshiro	14	3141	Japan	0.08
6	Stange, Daniel	12	1764	German	0.01
7	Barker, Nick	13	1707	Netherland	0.03
8	Koo, Bon-kyoung	15	1618	Netherland	0.25
9	Bartfeld, Sina	13	1405	German	0.03
10	Zavros, Yana	46	1312	United States	0.04
11	Wells, James	22	1040	United States	0.01
12	Spence, Jason	7	973	United States	0.00
13	Peek, Richard	5	715	United States	0.05
14	Schumacher, Michael	6	657	Japan	0.00
15	Chen, Zheng	12	615	United States	0.03

Table 2 The top 15 most cited institutions in gastric organoid field

Rank	Institution	Country	Publications	Citations	Centrality
1	University Medical Center Utrecht	Netherland	19	5083	0.18
2	Netherlands Institute for Developmental Biology Utrecht	Netherland	8	3064	0.00
3	University of Cincinnati	United States	33	1451	0.25
4	University of Hong Kong	Hongkong, China	6	1148	0.08
5	University of Michigan	United States	22	1104	0.04
6	Cincinnati Children’s Hospital Medical Center	United States	16	999	0.07
7	Columbia University	United States	11	986	0.05
8	Vanderbilt University	United States	22	941	0.25
9	Stanford University	United States	11	881	0.02
10	Cambridge University	United Kingdom	7	758	0.08
11	Harvard University	United States	12	731	0.08
12	Shinshu University	Japan	17	625	0.07
13	Keio University	Japan	13	602	0.13
14	Nanjing med University	China	14	600	0.20
15	Miami University	United States	7	556	0.00

Table 3 The 20 most popular keywords in the field of gastric organoids

Keyword	Freq	Centrality
Gastric cancer	177	0.06
Stem cell	110	0.04
Cancer stem cell	45	0.10
Differentiation	41	0.06
Helicobacter pylori	32	0.01
Metastasis	30	0.19
Proliferation	30	0.04
Resistance	29	0.06
Epithelial cell	27	0.16
Self-renewal	26	0.11
Apoptosis	22	0.07
Progression	22	0.04
Protein	20	0.03
Progenitor cell	18	0.04
Gene expression	18	0.05
Chief cell	17	0.04
Migration	16	0.01
Chemotherapy	16	0.07
Epithelial mesenchymal transition	14	0.02
Mutation	15	0.03

Table 4 The typical labels in each cluster

No.	Cluster label	Year	Label
0	Stem cell	2015	Stem cell; cancer; differentiation; model; acid gastric cancer; signet ring carcinoma; matrix metalloproteinase; spdef; transcription factor; stem cell; regeneration; gastric cancer; progenitor; in vitro expansion
1	Mouse	2018	Gastric cancer; transcription factor; regeneration; tumor suppressor genes; identification in vitro; expansion; liver; leptin deficiency; en-y gastric bypass; mouse; liver; infection; bariatric surgery; gastrointestinal cancer
2	Noncanonical nuclear factor-kappa B	2019	Gastric cancer; her2; capecitabine; open label; oxaliplatin drug screening; cancer organoids; precision medicine; Helicobacter pylori; living biobanks; cancer organoids; organoid; drug screenin; tptep1; secretion
3	Gastric cancer	2013	Gene; differentiation; receptor; lgr5; r spondin, gastric cancer; morphogenetic protein; epidermal growth factor receptor; Helicobacter pylori; tissue engineering; tumor microenvironment; receptor; gastric intestinal metaplasia; gene; csc markers (6.04, 0.05)
4	Targeted therapy	2016	Gastric cancer; cancer stem cell; endothelial growth; mammary stem cell; gastric cancers, cancer stem cells; translational research; tumor suppressor genes; gastric organoids; cancer microenvironment; abcg2; cancer stem cell; lgr4; acbp-3; cycle arrest
5	Polypeptide expression	2017	Cancer; progression; microenvironment; mmp 9; angiogenesis, gene expression; endoderm; gastrointestinal tract; mouse small intestine; gata4; gene expression; angiogenesis; epstein barr virus; toripalimab; mmp 9
6	Cell	2015	Goblet cell carcinoid; crypt cell adenocarcinoma; appendix; mucinous; neuroendocrine; amphophilic; crypt cell adenocarcinoma; appendix; amphophilic; mucinous; neuroendocrine
7	Expression	2012	Survival; tumor suppressor; her2; poor prognosis; amplification, organoids; stomach; chemotherapy; gastroids; proliferation; amplification; gastroids; myc; inactivation; conditional mouse model
8	Synthetic lethality	2019	Gastric cancer; gastric organoids; gland fission; gastric stem cells; mtor; mtor; gland fission; gastric stem cells; gastric organoids; gastric cancer
9	Autophagy	2014	Gastric cancer; Helicobacter pylori; base excision repair; stomach neoplasms; gastric stem cells, nf kappa; trefoil protein; Helicobacter pylori; robust model; atrophic gastritis; NF kappa b; Helicobacter pylori; inflammation; antral epithelium; dynamic histology
10	Cancer organoids	2020	Gastric cancer; resistance; cancer; cetuximab; heterogeneity, cancer stem cell; lauren classification; mucin phenotype expression; cluster; transcription factor; gastric cancer; cd44; stomach; cancer stem cell; chemoresistance
11	Tumor microenvironment	2017	Gastric cancer; t-cell infiltration; recombinant protein; precision oncology; cancer model, stem cell; stomach; promote; cancer; gene expression; targeted therapy; self-renewa; promote; anti-egfr single domain antibody; cancer evolution
12	abcg 2	2012	Gastric cancer; cancer stem cells; Helicobacter pylori; beta catenin; wound repair identification; stem cell; expression; inhibition; stomach; polypeptide expressing metaplasia; contribute; network; immune response; inhibition
13	Gene expression	2013	Gastric cancer; drug sensitivity; shaker; albumin-bound paclitaxel; stomach, breast cancer; model; growth; drug; identification; cell; breast cancer; growth; recombinant protein; irgd
14	Crypt cell adenocarcinoma	2018	Expression; stomach; stem cell; identification; progenitor cell, gastric cancer; stem cells; cancer biology; beta-galactoside alpha; sialic acid; expression; identification; pathogenesis; metaplasia; progenitor cell
15	Amplification	2015	Gastric cancer; cell adhesion; cell matrix interaction; magnetic resonance imaging; hereditary diffuse gastric cancer, synthetic lethality; discoidin domain receptor; diffuse gastric cancer; magnetic resonance imaging; hereditary diffuse gastric cancer; synthetic lethality; hdgc; e cadherin; e-cadherin; chemoprevention
16	mTOR	2015	Gastric cancer; stem-like subtype; adult mouse; cluster; cathepsin c ovarian; shaker; dynamic; fluid; peritoneal; autophagy; hypoxia inducible factor 1 alpha; cancer; metastasis; fibroblasts

Table 5 The Top10 co-cited literature

Ref.	Title	Journal	Freq	Centrality
Bartfeld et al[6], 2015	In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection	Gastroenterology	50	0.10
Bray et al[24], 2018	Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries	CA Cancer J Clin	49	0.00
Yan et al[9], 2018	A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening	Cell Stem Cell	45	0.05
Vlachogiannis et al[21], 2018	Patient-derived organoids model treatment response of metastatic gastrointestinal cancers	Science	43	0.06
Seidlitz et al[22], 2019	Human gastric cancer modelling using organoids	GUT	43	0.02
Schlaermann et al[7], 2016	A novel human gastric primary cell culture system for modelling Helicobacter pylori infection in vitro	GUT	37	0.09
Mccracken et al[20], 2014	Modelling human development and disease in pluripotent stem-cell-derived gastric organoids	Nature	35	0.05
Nanki et al[23], 2018	Divergent Routes toward Wnt and R-spondin Niche Independency during Human Gastric Carcinogenesis	Cell	32	0.07
Cancer Genome Atlas Research Network[26], 2014	Comprehensive molecular characterization of gastric adenocarcinoma	Nature	31	0.05
Stange et al[19], 2013	Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium	Cell	28	0.12