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©The Author(s) 2024.
World J Gastroenterol. Feb 21, 2024; 30(7): 742-758
Published online Feb 21, 2024. doi: 10.3748/wjg.v30.i7.742
Published online Feb 21, 2024. doi: 10.3748/wjg.v30.i7.742
Table 1 Methodological quality using the Newcastle-Ottawa scale
Ref. | Selection (/4) | Comparability (/2) | Outcome (/3) | Overall methodological quality |
Ichim et al[9], 2022 | 3 | 1 | 2 | Good |
Minaga et al[10], 2021 | 2 | 1 | 1 | Poor |
Takano et al[11], 2021 | 3 | 1 | 2 | Good |
Ichim et al[12], 2020 | 3 | 1 | 2 | Good |
Facciorusso et al[13], 2021 | 3 | 1 | 3 | Good |
Chon et al[14], 2019 | 3 | 1 | 2 | Good |
Akay et al[15], 2021 | 3 | 1 | 3 | Good |
Chen et al[16], 2020 | 3 | 1 | 3 | Good |
Hollerbach et al[17], 2003 | 3 | 1 | 2 | Good |
Singh et al[18], 2007 | 2 | 1 | 2 | Fair |
tenBerge et al[19], 2002 | 2 | 1 | 2 | Fair |
Lee et al[20], 2015 | 3 | 2 | 1 | Poor |
Oh et al[21], 2018 | 3 | 2 | 2 | Good |
Singh et al[22], 2009 | 3 | 1 | 2 | Good |
Okasha et al[23], 2023 | 3 | 1 | 2 | Good |
Hasan et al[24], 2019 | 2 | 1 | 3 | Good |
Bhogal et al[25], 2020 | 3 | 1 | 3 | Good |
Diehl et al[26], 2015 | 2 | 1 | 2 | Fair |
Sundaram et al[27], 2023 | 4 | 1 | 2 | Good |
Saab et al[28], 2017 | 2 | 1 | 1 | Poor |
Sey et al[29], 2016 | 3 | 2 | 1 | Poor |
Shah et al[30], 2017 | 2 | 1 | 1 | Poor |
Sisman et al[31], 2020 | 2 | 1 | 2 | Fair |
Stavropoulos et al[32], 2012 | 3 | 2 | 1 | Poor |
Zhang et al[33], 2021 | 3 | 1 | 2 | Good |
Huang et al[34], 2017 | 3 | 1 | 2 | Good |
Ogura et al[35], 2016 | 3 | 1 | 2 | Good |
Tanikawa et al[36], 2023 | 3 | 1 | 2 | Good |
Tonozuka et al[37], 2015 | 2 | 1 | 2 | Fair |
Carbajo et al[38], 2019 | 3 | 1 | 2 | Good |
Nakaji et al[39], 2016 | 3 | 1 | 2 | Good |
Frost et al[40], 2018 | 2 | 1 | 2 | Fair |
Bhat et al[41], 2016 | 3 | 1 | 2 | Good |
Bick et al[42], 2019 | 3 | 1 | 2 | Good |
Binmoeller et al[43], 2011 | 3 | 1 | 2 | Good |
Bazarbashi et al[44], 2020 | 3 | 2 | 1 | Poor |
Mukkada et al[45], 2018 | 3 | 1 | 2 | Good |
Lee et al[46], 2000 | 2 | 2 | 2 | Fair |
Gubler et al[47], 2014 | 2 | 1 | 2 | Fair |
Kozieł et al[48], 2019 | 3 | 1 | 2 | Good |
Romero-Castro et al[49], 2013 | 4 | 2 | 2 | Good |
Table 2 Characteristics of studies on the role of endoscopic ultrasound in the diagnosis of liver diseases
Ref. | Study design | Study location | Participants characteristics | Diagnostic test | Outcomes | |||
Sample | M/F | Age (yr) | Indication | |||||
Ichim et al[9], 2022 | Single-arm observational study | Romania | 30 | 17/13 | 64.3 | FLL | EUS-FNA | Diagnostic accuracy: 97% |
Complications: 1 patient | ||||||||
Minaga et al[10], 2021 | Retrospective study | Japan | 426 | 248/178 | 69 (63–75) | FLL | CEH-EUS | Diagnostic accuracy: 98.4% |
Takano et al[11], 2021 | Retrospective study | Japan | 106 | 60/46 | 68 (32–87) | FLL | EUS-FNA | Diagnostic accuracy: 96% |
Complications: 1 patient | ||||||||
Ichim et al[12], 2020 | Prospective study | Romania | 48 | 27/21 | 66.3 (40–83) | FLL | EUS-FNA | Diagnostic accuracy: 98% |
Complications: None | ||||||||
Facciorusso et al[13], 2021 | Retrospective study | Italy | 116 | 70/46 | NR | FLL | EUS-FNB | Diagnostic accuracy: 88.8% |
Complications: None | ||||||||
Chon et al[14], 2019 | Retrospective study | Korea | 58 | 35/23 | 68.1 (42–86) | FLL | EUS-FNB | Diagnostic accuracy: 89.7% |
Complications: 1 patient | ||||||||
Akay et al[15], 2021 | Retrospective study | Turkey | 25 | 15/10 | 62.73 ± 15.24 | FLL | EUS-FNA | Diagnostic accuracy: 86.3% |
Complications: None | ||||||||
Gheorghiu et al[50], 2022 | Prospective RCT | Romania | 30 | 21/9 | 60 (37–84) | FLL | EUS-FNA and EUS-FNB | Diagnostic accuracy: 100% and 86.7% for EUS-FNB and EUS-FNA, respectively |
Complications: None | ||||||||
Chen et al[16], 2020 | Retrospective study | China | 38 | 35/3 | 55.7 ± 11.8 | FLL | EUS-FNB | Diagnostic accuracy: 90% |
Complications: 3 patients | ||||||||
Hollerbach et al[17], 2003 | Prospective study | Germany | 41 | NR | 66 ± 7 | FLL | EUS-FNA | Diagnostic accuracy: 94% |
Complications: 2 patients | ||||||||
Singh et al[18], 2007 | Prospective study | United States | 17 | NR | 56 (43–85) | FLL | EUS and EUS-FNA | Diagnostic accuracy: 65% and 94% for EUS and EUS-FNA, respectively |
Complications: None | ||||||||
tenBerge et al[19], 2002 | Retrospective study | 26 | NR | NR | FLL | EUS-FNA | Diagnostic accuracy: 89% | |
Complications: 6 patients | ||||||||
Lee et al[20], 2015 | Retrospective study | Korea | 21 | 9/12 | 63 (37–81) | FLL | EUS-FNB | Diagnostic accuracy: 90.5% |
Complications: None | ||||||||
Oh et al[21], 2018 | Prospective study | Korea | 30 | 19/11 | 66.5 (55.5–74) | FLL | CEH-EUS and CEH-EUS-FNA | Diagnostic accuracy: 80% and 86.7% for CEH-EUS and CEH-EUS-FNA, respectively |
Complications: None | ||||||||
Singh et al[22], 2009 | Prospective study | United States | 131 | 128/3 | 67 (45–86) | FLL | EUS and EUS-FNA | Diagnostic accuracy: 97% and 98% for EUS and EUS-FNA, respectively |
Complications: None | ||||||||
Okasha et al[23], 2023 | Cross-sectional study | Egypt | 43 | 32/11 | 56 | FLL | EUS and EUS-FNA/FNB | Diagnostic accuracy: 94%, and 100% for EUS and EUS-FNA/FNB |
Complications: None | ||||||||
Ching-Companioni et al[51], 2019 | Prospective RCT | United States | 40 | NR | NR | PLD | EUS-FNA and EUS-FNB | Diagnostic accuracy: 100% |
Complications: 13 patients | ||||||||
Hasan et al[24], 2019 | Prospective study | United States | 40 | 14/26 | 61 (46.7–68.2) | PLD | EUS-FNB | Diagnostic accuracy: 100% |
Complications: 9 patients | ||||||||
Bhogal et al[25], 2020 | Retrospective study | United States | 513 | 244/269 | NR | PLD | EUS-FNA and EUS-FNB | Diagnostic accuracy: 99% |
Diehl et al[26], 2015 | Prospective study | United States | 110 | 48/62 | 53 (9–87) | PLD | EUS-FNA | Diagnostic accuracy: 98% |
Complications: 1 patient | ||||||||
Sundaram et al[27], 2023 | Retrospective study | India | 74 | 37/37 | 44.5 (18–79) | PLD | EUS-FNA | Diagnostic accuracy: 97.3% |
Complications: 5 patients | ||||||||
Saab et al[28], 2017 | Retrospective study | United States | 47 | 16/31 | 54 | PLD | EUS-FNB | Diagnostic accuracy: 100% |
Complications: 2 patients | ||||||||
Sey et al[29], 2016 | Cross-sectional study | United States | 75 | 24/51 | 51 | PLD | EUS-FNB | Diagnostic accuracy: 82.7% |
Complications: 2 patients | ||||||||
Shah et al[30], 2017 | Retrospective study | United States | 24 | NR | NR | PLD | EUS-FNB | Diagnostic accuracy: 96% |
Complications: 2 patients | ||||||||
Sisman et al[31], 2020 | Retrospective study | Turkey | 40 | 24/16 | 44 (22–72) | PLD | EUS-FNB | Diagnostic accuracy: 100% |
Complications: 2 patients | ||||||||
Stavropoulos et al[32], 2012 | Prospective case series | United States | 22 | 6/16 | 61 (32–79) | PLD | EUS-FNA | Diagnostic accuracy: 91% |
Complications: None | ||||||||
Zhang et al[33], 2021 | Prospective study | China | 12 | 9/3 | NR | PH | EUS-PPG | Technical success rate: 91.7% |
EUS-PPG correlates well with HVPG (r = 0.923) | ||||||||
Complications: None | ||||||||
Huang et al[34], 2017 | Prospective study | United States | 28 | 18/10 | 63 (30–80) | PH | EUS-PPG | Technical success rate: 100% |
EUS-PPG correlates well with clinical parameters of PH | ||||||||
Complications: None |
Table 3 Characteristics of studies on the therapeutic role of endoscopic ultrasound
Ref. | Study design | Study location | Participant characteristics | Condition | Intervention | Outcomes | |
Sample | M/F | ||||||
Ogura et al[35], 2016 | Retrospective study | Japan | 27 | 20/7 | Liver abscess | EUS-AD | Clinical success: 100% |
Technical success: 100% | |||||||
Complications: None | |||||||
Tanikawa et al[36], 2023 | Retrospective study | Japan | 8 | 4/4 | Liver abscess | EUS-AD | Clinical success: 87.5% |
Technical success: 87.5% | |||||||
Tonozuka et al[37], 2015 | Retrospective case series | Japan | NR | Liver abscess | EUS-AD | Clinical success: 100% | |
Technical success: 100% | |||||||
Complications: None | |||||||
Carbajo et al[38], 2019 | Retrospective study | Spain | 9 | NR | Liver abscess | EUS-AD | Clinical success: 88.9% |
Technical success: 88.9% | |||||||
Nakaji et al[39], 2016 | Retrospective study | Japan | 12 | 10/2 | Solid liver lesions | EUS-guided ethanol injection | Complications: 2 |
Overall survival: 91.7%, 75%, and 53.3% at 1, 2, and 3 years | |||||||
Jiang et al[52], 2016 | Case series | China | 26 | 17/9 | Solid liver lesions | EUS-guided ethanol injection and iodine-125 brachytherapy | Complications: None |
Frost et al[40], 2018 | Case series | Ireland | 8 | 7/1 | GV | EUS-guided thrombin injection | Complications: None |
Obliteration: 75% | |||||||
Rebleeding: 1 patient | |||||||
Bhat et al[41], 2016 | Retrospective study | United States | 152 | 97/55 | GV | EUS-guided CYA and coil embolization | Technical success: 99% |
Obliteration: 93% | |||||||
Rebleeding: 20 patients | |||||||
Complications: 9 patients | |||||||
Bick et al[42], 2019 | Retrospective study | United States | 104 | 62/42 | GV | EUS-guided CYA | Obliteration: 79% |
Rebleeding: 12 patients | |||||||
Complications: 13 patients | |||||||
Binmoeller et al[43], 2011 | Retrospective study | United States | 30 | 19/11 | GV | EUS-guided CYA and coil embolization | Technical success: 100% |
Obliteration: 95.8% | |||||||
Rebleeding: 4 patients | |||||||
Complications: None | |||||||
Bazarbashi et al[44], 2020 | Prospective study | United States | 40 | 27/13 | GV | EUS-Guided coil embolization | Technical success: 100% |
Obliteration: 100% | |||||||
Complications: 1 patient | |||||||
Lôbo et al[53], 2019 | RCT | Brazil | 32 | 13/19 | GV | EUS-guided CYA and coil embolization | Complications: 13 patients |
Obliteration: 93.3% | |||||||
Mukkada et al[45], 2018 | Retrospective study | India | 30 | NR | GV | EUS-Guided coil embolization | Rebleeding: 6 patients |
Lee et al[46], 2000 | Prospective study | China | 101 | 69/32 | GV | EUS-guided CYA | Obliteration: 79.6% |
Complications: 22 patients | |||||||
Rebleeding: 19 patients | |||||||
Gubler et al[47], 2014 | Retrospective study | Switzerland | 40 | 25/15 | GV | EUS-guided CYA | Complications: 2 patients |
Kozieł et al[48], 2019 | Retrospective study | Poland | 16 | 9/7 | GV | EUS-guided CYA and coil embolization | Technical success: 94% |
Complications: 6 patients | |||||||
Romero-Castro et al[49], 2013 | Retrospective study | Germany | 30 | 22/8 | GV | EUS-guided coil embolization | Obliteration: 90.9% |
Complications: 1 patient | |||||||
Rebleeding: None |
Table 4 Outcomes of endoscopic ultrasound-guided interventions in the management of gastric varices
Outcome | Cumulative analyses (95%CI) | Subgroup analyses (95%CI) | |||
EUS-CYA | EUS-Coil | EUS-CYA + Coil | EUS-thrombin | ||
Technical success | 0.98 (0.92–0.99) | NR | 0.96 (0.55–0.99) | 0.98 (0.92–0.99) | NR |
Obliteration | 0.84 (0.79–0.88) | 0.78 (0.70–0.85) | 0.93 (0.71–0.99) | 0.93 (0.88–0.97) | 0.75 (0.38–0.94) |
Complications | 0.15 (0.07–0.28) | 0.20 (0.07–0.44) | 0.10 (0.02–0.31) | 0.22 (0.04–0.69) | 0.06 (0.003–0.51) |
Rebleeding | 0.17 (0.13–0.23) | 0.26 (0.13–0.49) | 0.08 (0.02–0.34) | 0.16 (0.11–0.23) | 0.13 (0.02–0.54) |
- Citation: Gadour E, Awad A, Hassan Z, Shrwani KJ, Miutescu B, Okasha HH. Diagnostic and therapeutic role of endoscopic ultrasound in liver diseases: A systematic review and meta-analysis. World J Gastroenterol 2024; 30(7): 742-758
- URL: https://www.wjgnet.com/1007-9327/full/v30/i7/742.htm
- DOI: https://dx.doi.org/10.3748/wjg.v30.i7.742