Mapping the evolution of liver aging research: A bibliometric analysis

Table 1 The top 10 most productive countries

Rank	Country	Publications	Frequency	TC	AC	SCP	MCP	Ratio
1	United States	1008	0.251	55205	54.77	794	214	0.212
2	China	820	0.2042	16228	19.79	674	146	0.178
3	Japan	428	0.1066	14259	33.32	366	62	0.145
4	Italy	205	0.051	6551	31.96	150	55	0.268
5	Spain	167	0.0416	6774	40.56	125	42	0.251
6	Korea	153	0.0381	3826	25.01	109	44	0.288
7	Germany	152	0.0378	6511	42.84	90	62	0.408
8	United Kingdom	140	0.0349	8635	61.68	87	53	0.379
9	France	119	0.0296	9485	79.71	91	28	0.235
10	India	84	0.0209	1712	20.38	71	13	0.155

Frequency: Number of articles published per country/total number of articles published. Total number of articles published is 4016 (among the total 4288 published articles, 272 articles lack the information of countries). TC: Total citations; AC: Average citations; SCP: Single country publication; MCP: Multiple country publication; Ratio: Multiple country publication/publications.

Table 2 The top 10 institutions with the most publications

Institution	NP	TC	AC	Country
University of Texas	71	3599	50.69	United States
Tokyo Metropolitan Institute of Gerontology	60	1868	31.13	Japan
University of Sydney	57	2693	47.25	Australia
National Institute on Aging	54	2683	49.69	United States
Harvard University	50	4133	82.66	United States
University of California, Los Angeles	44	2711	61.61	United States
University of Pittsburgh	44	2299	52.25	United States
Chinese Academy of Sciences	43	792	18.42	China
Albert Einstein College of Medicine	42	3510	83.57	United States
Shanghai Jiao Tong University	42	1220	29.05	China

NP: Number of publications; TC: Total citations; AC: Average citations.

Table 3 The 10 most prolific authors

Rank	Author	Country	NP	TC	H-index	G-index	Year
1	Akihito Ishigami	Japan	30	590	16	23	2008
2	David G. Le Couteur	Australia	28	1463	16	28	2007
3	Victoria C. Cogger	Australia	26	1417	17	26	2007
4	Gianfranco Alpini	United States	25	541	14	23	2015
5	Heather Francis	United States	24	466	14	21	2017
6	Naoki Maruyama	Japan	21	1180	16	21	1992
7	Rafael De Cabo	United States	20	896	14	20	2007
8	Shannon Glaser	United States	20	388	12	19	2017
9	Lindsey Kennedy	United States	19	329	10	18	2017
10	Tian-Hao Zhou	China	19	345	10	18	2017

Year: The publication year of the first paper related to liver aging. NP: Number of publications; TC: Total citations.

Table 4 The top 10 journals with the most publications

Rank	Journal	Country	JIF	H-index	G-index	TC	NP	Year
1	Mechanisms of Ageing and Development	Switzerland	5.3	42	65	6053	192	1984
2	Experimental Gerontology	United Kingdom	3.9	38	64	4761	132	1985
3	Hepatology	United States	13.5	43	82	6929	82	1985
4	Journals of Gerontology Series A-Biological Sciences and Medical Sciences	United States	5.1	33	52	2948	81	1995
5	Aging Cell	United Kingdom	7.8	33	65	4351	76	2002
6	Aging-US	United States	5.2	22	35	1397	65	2009
7	Biogerontology	Netherlands	4.5	25	41	1831	63	2001
8	Plos One	United States	3.7	28	40	1730	57	2008
9	Biochemical and Biophysical Research Communications	United States	3.1	24	41	1809	56	1987
10	Scientific Reports	United Kingdom	4.6	21	38	1566	56	2011

Year: The publication year of the first paper related to liver aging. JIF: Journal impact factor (2022); NP: Number of publications; TC: Total citations.

Table 5 The top 5 most cited articles

Rank	Ref.	Year	Journal	Title	JIF	TC	AC
1	Poynard et al[46]	1997	Lancet	Natural history of liver fibrosis progression in patients with chronic hepatitis C. The OBSVIRC, METAVIR, CLINIVIR, and DOSVIRC groups	168.9	2444	87.29
2	Xue et al[47]	2007	Nature	Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas	64.8	1886	104.78
3	Yoshimoto et al[48]	2013	Nature	Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome	64.8	1469	122.33
4	Krizhanovsky et al[71]	2008	Cell	Senescence of activated stellate cells limits liver fibrosis	64.5	1375	80.88
5	Estes et al[72]	2018	Hepatology	Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease	14	1250	178.57

JIF: Journal impact factor (2022); TC: Total citations; AC: Average citations.

Table 6 Details of the historical literature on liver aging

Ref.	Title	Journal	Cited frequency
Ji et al[49], 1990	Alteration of antioxidant enzymes with aging in rat skeletal muscle and liver	American Journal of Physiology	197
Michael et al[50], 2000	Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction	Molecular Cell	971
Yoshimoto et al[48], 2013	Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome	Nature	1469