Human leukocyte antigen compatibility and incidence of donor-specific antibodies in pediatric liver transplant recipients

Table 1 Patients’ characteristics, n (%)

Number of patients included	67
Gender, male	37 (55)
Age at transplant (months), median (IQR)	11.9 (7.7 to 24.6)
Weight at transplant (kg), median (IQR)	7.4 (6.4 to 11.5)
Z-score BMI, median (IQR)	-0.4 (-1.3 to -1.0)
PELD score, median (IQR)	14 (6 to 22)
GRWR (%), median (IQR)	3.2 (2.5 to 4.0)
Transplant modality
Living donor	60 (90)
Deceased donor	7 (10)
Baseline disease
Biliary atresia	38 (57)
Acute liver failure	3 (4.4)
Alagille syndrome	6 (9)
Primary liver tumor	4 (6)
Other	16 (24)

IQR: Interquartile range; BMI: Body mass index; GRWR: Graft-to-recipient weight ratio.

Table 2 Analysis of human leucocyte antigen A, B, and DR mismatch and the presence of rejection, n (%)

	With rejection, n = 12	Without rejection, n = 53	P value
HLA A MM			0.08
0	1 (8.3)	3 (5.7)
1	7 (58.3)	45 (84.9)
2	4 (33.3)	5 (9.4)
HLA B MM			0.12
0	0	5 (9.4)
1	7 (58.3)	39 (73.6)
2	5 (41.7)	9 (17)
HLA DR MM			0.9
0	1 (8.3)	4 (7.5)
1	9 (75)	41 (77.4)
2	2 (16.7)	8 (15.1)
Class I MM
1	1 (8.3)	8 (15.1)	0.16
2	6 (50)	37 (69.8)
3	1 (8.3)	3 (5.7)
4	4 (33.3)	5 (9.4)
Total MM			0.52
2	2 (16.7)	11 (20.8)
3	5 (41.7)	32 (60.4)
4	1 (8.3)	3 (5.7)
5	2 (16.7)	3 (5.7)
6	2 (16.7)	4 (7.5)

HLA: Human leucocyte antigen; MM: Mismatch value.