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©The Author(s) 2024.
World J Gastroenterol. Aug 21, 2024; 30(31): 3668-3679
Published online Aug 21, 2024. doi: 10.3748/wjg.v30.i31.3668
Published online Aug 21, 2024. doi: 10.3748/wjg.v30.i31.3668
Table 1 Baseline characteristics of the two groups
Item | Non-HE group (n = 22) | HE group (n = 8) | P value |
Sex | |||
Male | 15 | 4 | 0.36 |
Female | 7 | 4 | |
Age, years | 56.18 ± 18.81 (35-78) | 53 ± 17.66 (28-71) | 0.76 |
Portal vein thrombosis | |||
Yes | 12 | 5 | 0.70 |
No | 10 | 3 | |
Child-Pugh score | |||
A | 10 | 4 | 0.39 |
B | 12 | 3 | |
C | 0 | 1 | |
HVPG, mmHg | 14.26 ± 9.15 (2-25) | 11.75 ± 6.92 (4-22) | 0.45 |
MELD score | 8.33 ± 5.52 (0.31-20.95) | 5.42 ± 2.83 (1.80-10.22) | 0.08 |
Total bile acid, μmol/L | 30.93 ± 20.64 (5.00-69.80) | 52.58 ± 46.28 (8.60-152.70) | 0.51 |
Table 2 Relationship of the top 20 abundant bacteria and bacteria whose abundance differed significantly within the two groups post-transjugular intrahepatic portosystemic shunt
HE group | Non-HE group | ||
Positive correlation | |||
Clostridia | Clostridialesa | Bacilli | Lactobacillalesa |
Lenta | Eggerthellaa | Streptococcacea, Streptococcus | Lactobacillusc, Eubacteriumc, Bifidobacteriumc, |
Veillonella | Slackiab | ||
Prevotella | Morganellab | ||
Blautia | Clostridiab, Clostridialesb | ||
Negative correlation | |||
Lactobacillus | Slackiac | Enterococcus | Streptococcaceaeb, Streptococcusb |
Dorea | Ulic | Parabacteroides | Lactobacillalesb, Bacillib |
Citrobacter | Clostridiac, Clostridialesc |
- Citation: Zhao HW, Zhang JL, Liu FQ, Yue ZD, Wang L, Zhang Y, Dong CB, Wang ZC. Alterations in the gut microbiome after transjugular intrahepatic portosystemic shunt in patients with hepatitis B virus-related portal hypertension. World J Gastroenterol 2024; 30(31): 3668-3679
- URL: https://www.wjgnet.com/1007-9327/full/v30/i31/3668.htm
- DOI: https://dx.doi.org/10.3748/wjg.v30.i31.3668