Alterations in the gut microbiome after transjugular intrahepatic portosystemic shunt in patients with hepatitis B virus-related portal hypertension

Table 1 Baseline characteristics of the two groups

Item	Non-HE group (n = 22)	HE group (n = 8)	P value
Sex
Male	15	4	0.36
Female	7	4
Age, years	56.18 ± 18.81 (35-78)	53 ± 17.66 (28-71)	0.76
Portal vein thrombosis
Yes	12	5	0.70
No	10	3
Child-Pugh score
A	10	4	0.39
B	12	3
C	0	1
HVPG, mmHg	14.26 ± 9.15 (2-25)	11.75 ± 6.92 (4-22)	0.45
MELD score	8.33 ± 5.52 (0.31-20.95)	5.42 ± 2.83 (1.80-10.22)	0.08
Total bile acid, μmol/L	30.93 ± 20.64 (5.00-69.80)	52.58 ± 46.28 (8.60-152.70)	0.51

HE: Hepatic encephalopathy; HVPG: Hepatic venous pressure gradient; MELD: Model for end-stage liver disease.

Table 2 Relationship of the top 20 abundant bacteria and bacteria whose abundance differed significantly within the two groups post-transjugular intrahepatic portosystemic shunt

HE group		Non-HE group
Positive correlation
Clostridia	Clostridialesa	Bacilli	Lactobacillalesa
Lenta	Eggerthellaa	Streptococcacea, Streptococcus	Lactobacillusc, Eubacteriumc, Bifidobacteriumc, Veillonellac
Veillonella	Slackiab
Prevotella	Morganellab
Blautia	Clostridiab, Clostridialesb
Negative correlation
Lactobacillus	Slackiac	Enterococcus	Streptococcaceaeb, Streptococcusb
Dorea	Ulic	Parabacteroides	Lactobacillalesb, Bacillib
Citrobacter	Clostridiac, Clostridialesc

^aP < 0.001.

^bP < 0.01.

^cP < 0.05.

HE: Hepatic encephalopathy.