Calcium/calcimimetic via calcium-sensing receptor ameliorates cholera toxin-induced secretory diarrhea in mice

Table 1 Intestinal fluid secretory responses to cholera toxin and R568 calcimimetic in calcium-sensing receptor wild type and mutant mouse intestine

Group	Intestinal fluid accumulation in mg fluid/mg intestine
	Wild type	villinCre/Casrflox/flox	nestinCre/Casrflox/flox
Control	0.20 ± 0.02 (11)	0.59 ± 0.13 (7)a	0.17 ± 0.02 (6)
R568 (50 mg/kg)	0.15 ± 0.09 (5)	0.61 ± 0.11 (5)	0.15 ± 0.11 (5)
CTX (0.5 mg/kg)	1.46 ± 0.15 (10)c	0.80 ± 0.03 (5)b	0.55 ± 0.14 (6)b
CTX (0.5 mg/kg) + R568 (50 mg/kg)	0.92 ± 0.16 (6)d	0.82 ± 0.09 (5)	0.95 ± 0.29 (5)

^aP < 0.05 vs wild type.

^bP < 0.05 vs control.

^cP < 0.01 vs control.

^dP < 0.05 vs cholera toxin alone.

Data are means ± standard error of means (n). CTX: Cholera toxin.