Prevalence of Helicobacter pylori infection among patients with esophageal carcinoma

Table 1 Baseline characteristics of all patients, n (%)

Number of patients	n = 89
Age (median, yr)	66 (26-93)
Sex
Male	69 (77.52)
Female	20 (22.47)
Histology
Adenocarcinoma	47 (52.80)
Squamous cell carcinoma	37 (41.57)
Others	4 (5.5)
Tumor location
Gastroesophageal junction	33 (70.21)
Esophageal	14 (29.78)
Stage
Stage I-II	25 (28.08)
Stage III-IV	54 (60.67)
Presence of Helicobacter pylori	4 (4.5)
Adenocarcinoma	3 (6.3)
Squamous cell carcinoma	1 (2.7)
Previous PPI treatments	86 (96.82)

PPI: Proton pump inhibitor.

Table 2 Studies regarding Helicobacter pylori infection and esophageal carcinoma

Paper characteristics				Sample characteristics
Ref.	Country	Year	Design	Age (mean, yr)	Helicobacter pylori prevalence	Tumor	Location
Holleczek et al[23]	Germany	2020	Cohort	62.2	47.80%	EA	Gastric cardia; esophagus esophagogastric junction
Wu et al[27]	Taiwan	2009	Case-control	58.3	35.30%	ESCC	Upper, middle or lower third of the esophagus
Khoshbaten et al[28]	Iran	2011	Case-control	63.9 cases; 61.3 controls	41.2% ± 36.95% cases; 56.2% ± 29.5% controls	ESCC	Esophagus
Hu et al[29]	Taiwan	2009	Case-control	50-70	37% cases; 53% controls	ESCC	Upper, middle or lower third esophagus
Cook et al[30]	Finland	2010	Case-control	57.7 cases; 58.1 controls	80.28% cases; 78.16% controls	ESCC	Upper, middle, and lower third of the esophagus
Murphy et al[18]	Finland	2012	Case-control	57.9 cases; 57.9 controls	78.04% cases; 76.82% controls	ESCC	Esophagus

EA: Esophageal adenocarcinoma; ESCC: Esophageal squamous cell carcinoma.