Identification of an immune-related gene signature for predicting prognosis and immunotherapy efficacy in liver cancer via cell-cell communication

doi:10.3748/wjg.v30.i11.1609

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 21, 2024; 30(11): 1609-1620
Published online Mar 21, 2024. doi: 10.3748/wjg.v30.i11.1609

Table 1 Number of times cell groups served as a source and target in immune-related pathways

	Number of times
Cell group	12	15	6	2	10	9	14	11	8	1	7	13	3	5	4
Frequency	195	195	100	84	76	72	65	50	48	44	41	35	26	22	9

Table 2 Coefficients and P values corresponding to diagnostic-related genes in multivariable Cox regression

Gene	Coefficient	P value
NUSAP1	-0.108515073	0.219706452
STMN1	0.367886836	0.006598885
UBE2C	-0.038808062	0.692223045
CKS1B	0.019614361	0.885123337
HMGB1	-0.036928764	0.841313659
CCL5	-0.351813314	0.000909645
DUT	-0.200404711	0.201189097
PFN1	0.156824573	0.389822262
ITM2A	-0.021567354	0.742760958
CCL4	0.146793282	0.182629575
CFL1	0.688652826	0.001683044
IL32	-0.054741614	0.491028415
MT2A	0.033545401	0.525093809
IFITM3	-0.053229362	0.706251853

NUSAP1: Nucleolar and spindle associated protein 1; STMN1: Stathmin 1; UBE2C: Ubiquitin conjugating enzyme E2 C; CKS1B: CDC28 protein kinase regulatory subunit 1B; HMGB1: High mobility group box 1; CCL5: C-C chemokine ligand 5; DUT: Deoxyuridine triphosphatase; PFN1: Profilin 1; ITM2A: Integral membrane protein 2A; CCL4: C-C chemokine ligand 4; CFL1: Cofilin 1; IL32: Interleukin 32; MT2A: Metallothionein 2A; IFITM3: Interferon induced transmembrane protein 3.

Citation: Li JT, Zhang HM, Wang W, Wei DQ. Identification of an immune-related gene signature for predicting prognosis and immunotherapy efficacy in liver cancer via cell-cell communication. World J Gastroenterol 2024; 30(11): 1609-1620
URL: https://www.wjgnet.com/1007-9327/full/v30/i11/1609.htm
DOI: https://dx.doi.org/10.3748/wjg.v30.i11.1609