Copyright
©The Author(s) 2024.
World J Gastroenterol. Mar 21, 2024; 30(11): 1572-1587
Published online Mar 21, 2024. doi: 10.3748/wjg.v30.i11.1572
Published online Mar 21, 2024. doi: 10.3748/wjg.v30.i11.1572
Characteristic | n (%) |
Age (SD) | 35.6 (9.4) |
Male | 8 (81.8) |
Female | 3 (18.2) |
Age at diagnosis (Montreal classification) | |
A1 (age < 16 yr) | 1 (9.1) |
A2 (age 17-40 yr) | 9 (81.8) |
A3 (age > 40 yr) | 1 (9.1) |
Location (Montreal classification) | |
L1 (terminal ileum disease) | 5 (45.5) |
L2 (colonic disease) | 3 (27.3) |
L3 (ileocolonic disease) | 3 (27.3) |
L4 (upper GI) | 0 (0.0) |
Behavior (Montreal classification) | |
B1 (inflammatory) | 3 (27.3) |
B2 (stricturing) | 4 (36.4) |
B3 (penetrating) | 2 (18.2) |
B2 + B3 | 2 (18.2) |
Perianal disease | 4 (36.4) |
Duration of disease, mean (SD), yr | 8.8 (6.9) |
Medication at the time of WMT | |
None | 2 (18.2) |
Mesalamines | 7 (63.6) |
Steroids | 1 (9.1) |
Immunomodulators | 3 (27.3) |
Biologics therapy | 1 (9.1) |
Bowel surgery | 2 (18.2) |
Anal surgery | 4 (36.4) |
Smoking status | |
Current | 0 (0.0) |
Ex-smoker | 2 (18.2) |
Never smoker | 9 (81.8) |
Disease severity | |
Mild | 11 (100.0) |
Moderate | 0 (0.0) |
Severe | 0 (0.0) |
Route of WMT | |
Mid-gut TET | 4 (36.4) |
Colonic TET | 7 (63.6) |
Variable | Responders1 | Non-responders1 | ||||||
n | Baseline, mean ± SD | 3-month post-WMT, mean ± SD | P value | n | Baseline, mean ± SD | 3-month post-WMT, mean ± SD | P value | |
HBI (three-month post-WMT) | 7 | 5.7 ± 0.8 | 2.4 ± 0.5 | 0.014 | 4 | 5.0 ± 0.0 | 7.0 ± 2.3 | 0.157 |
CDAI (three-month post-WMT) | 7 | 196.5 ± 21.7 | 76.4 ± 29.5 | 0.018 | 4 | 190.0 ± 13.3 | 238.5 ± 50.1 | 0.068 |
Stool frequency (number/d) | 7 | 1.7 ± 1.0 | 0.6 ± 0.5 | 0.023 | 4 | 1.5 ± 0.6 | 3.5 ± 2.4 | 0.180 |
Pain (scale 0-3) | 7 | 0.7 ± 0.5 | 0.3 ± 0.5 | 0.083 | 4 | 0.5 ± 0.6 | 0.5 ± 0.6 | 1.000 |
hs-CRP (mg/L) | 7 | 3.6 ± 6.1 | 2.1 ± 2.0 | 0.500 | 4 | 14.8 ± 15.8 | 29.6 ± 19.0 | 0.144 |
ESR (mm/h) | 7 | 15.9 ± 17.0 | 10.9 ± 11.2 | 0.340 | 4 | 43.3 ± 31.6 | 54.0 ± 33.0 | 0.273 |
Fecal calprotectin (ug/g) | 6 | 367.6 ± 159.9 | 374.2 ± 290.4 | 0.753 | 4 | 391.6 ± 120.9 | 561.2 ± 140.2 | 0.144 |
SES CD score | 4 | 5.3 ± 2.1 | 3.3 ± 2.5 | 0.285 | 4 | 9.3 ± 7.4 | 17.5 ± 7.1 | 0.068 |
- Citation: Chen SJ, Zhang DY, Wu X, Zhang FM, Cui BT, Huang YH, Zhang ZL, Wang R, Bai FH. Washed microbiota transplantation for Crohn’s disease: A metagenomic, metatranscriptomic, and metabolomic-based study. World J Gastroenterol 2024; 30(11): 1572-1587
- URL: https://www.wjgnet.com/1007-9327/full/v30/i11/1572.htm
- DOI: https://dx.doi.org/10.3748/wjg.v30.i11.1572