Changes in p53 and Waf1p21 expression and cell proliferation in esophageal carcinogenesis

Table 1 Changes in p53, Waf1p21 and Proliferating Cell Nuclear Antigen expression in esophageal cancer patients from Henan, China (¯x ± s).

Histology	p53 immunostaining			Waf1p21 immunostaining			Proliferating Cell Nuclear Antigen immunostaining
	Positive		Positive cells/mm2	Positive		Positive cells/mm2	Samples examined	Positive cells/mm2
	%	(n/n)		%	(n/n)
Normal	74.2	(23/31)	53 ± 78	39.3	(11/28)	34 ± 72	31	200 ± 113
BCH	87.2	(102/117)	74 ± 66	37.8	(14/37)	53 ± 10	106	286 ± 150
DYSb	100	(31/31)	262 ± 341	27.3	(3/11)	11 ± 20.2	31	719 ± 389
SCC	88.5	(23/26)	1297 ± 1110	14.3	(1/7)	8 ± 22	26	1261 ± 545

^bP < 0.01, vs BCH and SCC, by Wilcoxon rank_sum test. SCC: Squamous cell carcinoma; DYS: Dysplasia; BCH: Basal cell hyperplasia.