Copyright
©The Author(s) 2023.
World J Gastroenterol. Feb 28, 2023; 29(8): 1243-1260
Published online Feb 28, 2023. doi: 10.3748/wjg.v29.i8.1243
Published online Feb 28, 2023. doi: 10.3748/wjg.v29.i8.1243
Table 1 Predictors of early hepatocellular carcinoma recurrence after curative treatment
Predictors related to HCC characteristics | Ref. | Predictors related to patient characteristics | Ref. | Predictors related to treatment | Ref. |
Size | Liver cirrhosis | [37,41] | RFA (vs LR) | [41,88,89] | |
> 2.6 cm | [42] | ||||
> 3 cm | [36,41] | ||||
Multifocality | [41] | Liver insufficiency (CPS, MELD, ALBI) | [37,56-58] | LR: | |
Liver resection margins invasion | [44] | ||||
Liver resection margins < 1 cm | [43,86] | ||||
Non-anatomical resection1 | [45] | ||||
Beyond Milan criteria | [43] | High total bilirubin | [42] | RFA: ablation margins < 1 cm | [91] |
Microvascular invasion | [34,36,38,40,44,45] | Male sex | [37] | ||
Lack of capsule integrity | [34,42] | High PLR | [49,59,60] | ||
Poor histological differentiation | [36,43,47] | High NLR | [49,60] | ||
High AFP | [36,41,50] | DAAs therapy | |||
> 10 ng/mL | [48] | Predictor | [62,63] | ||
> 32 ng/mL | [45] | Non-predictor | [64-76] | ||
> 400 ng/mL | [40] | Protective | [77-83] | ||
High PIVKA-II | [41,52,55] | High viral load in HBV infected patients | [109] | ||
> 46.0 mAU/mL | [38] | ||||
> 375.5 mAU/mL | [51] |
Table 2 Predictors of late hepatocellular carcinoma recurrence after curative treatment
Predictors related to HCC characteristics | Ref. | Predictors related to patient characteristics | Ref. | Predictors related to treatment | Ref. |
Size > 5 cm | [92] | Liver cirrhosis | [32,41,43,84,93-96] | RFA (vs LR) | [41,88,117-119] |
Multifocality | [92,93] | Old age | [41,92] | ||
Microvascular invasion | [92] | Male sex | [93] | ||
AFP > 400 μg/L | [94] | LSM | [43,102] | ||
Portal hypertension | |||||
SSM (> 70 kPa) | [43] | ||||
Splenic volume (> 165 mL) | [40] | ||||
Platelet count | [43,103,104] | ||||
Esophageal varices | [43,103] | ||||
HBV infection | |||||
High viral load | [105,108] | ||||
Low viral load | [111] | ||||
High HBsAg levels | [84,86,103,107] |
- Citation: Nevola R, Ruocco R, Criscuolo L, Villani A, Alfano M, Beccia D, Imbriani S, Claar E, Cozzolino D, Sasso FC, Marrone A, Adinolfi LE, Rinaldi L. Predictors of early and late hepatocellular carcinoma recurrence. World J Gastroenterol 2023; 29(8): 1243-1260
- URL: https://www.wjgnet.com/1007-9327/full/v29/i8/1243.htm
- DOI: https://dx.doi.org/10.3748/wjg.v29.i8.1243