Gastric cancer incidence based on endoscopic Kyoto classification of gastritis

Table 1 Demographic characteristics and endoscopic findings of the patient at baseline

	All	Gastric cancer	Non-gastric cancer	P value1
No.	6718	34	6684
Age, median (IQR), yr	54 (46-64)	69.5 (57.8-73.8)	54 (46-64)	< 0.001
Male sex, No. (%)	2969 (44.2)	17 (50.0)	2952 (44.2)	0.495
H. pylori status, No. (%)				< 0.001
Uninfected	3754 (55.9)	5 (14.7)	3749 (56.1)
Eradicated	2264 (33.7)	20 (58.8)	2244 (33.6)
Currently infected	700 (10.4)	9 (26.5)	691 (10.3)
Duration of follow up, median (IQR), yr	2.56 (1.74-3.64)	1.03 (0.85-1.78)	2.57 (1.76-3.64)	< 0.001
No. EGD per patient, median (IQR)	2 (2-4)	2 (2-3)	2 (2-4)	0.652
Kyoto classification score, median (IQR)
Atrophy	0 (0-1)	2 (1-2)	0 (0-1)	< 0.001
Intestinal metaplasia	0 (0-0)	2 (0-2)	0 (0-0)	< 0.001
Enlarged folds	0 (0-0)	0 (0-0)	0 (0-0)	< 0.001
Nodularity	0 (0-0)	0 (0-0)	0 (0-0)	0.916
Diffuse redness	0 (0-0)	1 (1-1)	0 (0-0)	< 0.001
Total Kyoto	0 (0-2)	5 (4-5)	0 (0-2)	< 0.001

¹P values were calculated using binomial logistic regression model.

IQR: Interquartile range; EGD: Esophagogastroduodenoscopy; H. pylori: Helicobacter pylori.

Table 2 Characteristics of gastric cancers

	n
Gastric cancer patient	34
Gastric cancer lesion	37
Morphological type1
Superficial elevated (0-IIa)	7
Superficial flat (0-IIb)	5
Superficial depressed (0-IIc)	25
Depth
Mucosa	33
Submucosa	4
Lauren’s histological type
Diffuse	4
Intestinal	33

¹According to the Japanese classification of gastric carcinoma[22].

Table 3 Univariate and multivariate analysis of gastric cancer development

	GC patients, No.	Non-GC patients, No.	Crude HR1	95%CI	P value	Adjusted HR1,2	95%CI	P value
Age (yr)
< 50	4	2383	Reference
50-59	5	2014	1.48	0.40-5.50	0.562
60-69	8	1352	3.37	1.01-11.19	0.047
≥ 70	17	935	10.75	3.62-31.96	< 0.001
Sex
Women	17	3732	Reference
Men	17	2952	1.27	0.65-2.48	0.488
H. pylori status
Uninfected	5	3749	Reference			Reference
Eradicated	20	2244	6.00	2.25-16.05	< 0.001	3.81	1.40-10.38	0.009
Currently infected	9	691	11.60	3.88-34.64	< 0.001	9.53	3.17-28.65	< 0.001
Atrophy
0	4	3992	Reference			Reference
1	7	1508	4.40	1.29-15.06	0.018	3.66	1.06-12.61	0.040
2	23	1184	19.02	6.56-55.12	< 0.001	11.60	3.82-35.27	< 0.001
Intestinal metaplasia
0	10	5516	Reference			Reference
1	3	473	3.42	0.94-12.44	0.062	2.25	0.60-8.43	0.228
2	21	695	16.01	7.52-34.05	< 0.001	9.92	4.37-22.54	< 0.001
Enlarged folds
0	28	6429	Reference			Reference
1	6	255	5.41	2.23-13.10	< 0.001	4.03	1.63-9.96	0.003
Nodularity
0	33	6507	Reference			Reference
1	1	177	1.18	0.16-8.62	0.872	2.51	0.33-18.86	0.372
Diffuse redness
0	8	5058	Reference			Reference
1	18	1187	9.05	3.92-20.85	< 0.001	6.22	2.65-14.56	< 0.001
2	8	439	12.26	4.60-32.68	< 0.001	10.01	3.73-26.86	< 0.001
Total Kyoto
0-1	6	4615	Reference			Reference
2-3	2	1008	1.48	0.30-7.34	0.631	1.12	0.22-5.63	0.887
4	6	473	9.54	3.07-29.62	< 0.001	6.23	1.93-20.13	0.002
5-8	20	588	25.58	10.25-63.84	< 0.001	16.45	6.29-43.03	< 0.001

¹Hazard ratios were calculated using the Cox proportional hazards model.

²Hazard ratios were adjusted for age and sex.

GC: Gastric cancer; HR: Hazard ratio; CI: Confidence interval; H. pylori: Helicobacter pylori.