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©The Author(s) 2023.
World J Gastroenterol. May 28, 2023; 29(20): 3048-3065
Published online May 28, 2023. doi: 10.3748/wjg.v29.i20.3048
Published online May 28, 2023. doi: 10.3748/wjg.v29.i20.3048
Table 1 Preclinical studies evaluating the antimicrobial activity of several Hericium erinaceus fraction toward Helicobacter pylori
Ref. | H. erinaceus fraction employed | Extraction method | Anti-H.pylori MIC (µg/mL) |
Shang et al[50], 2013 | Ethyl acetate fractions | 62.5-250.01 | |
Zhu et al[51], 2014 | HEP25 (197 kDa) | Ethanol precipitation (ethanol concentration 25%) | 3202 |
HEP75 (20 kDa) | Ethanol precipitation (ethanol concentration 75%) | 1602 | |
Bi3+plus HEP25 | Complexation of peptides with bismuth[54] | 202 | |
Bi3+plus HEP75 | 202 | ||
Liu et al[52], 2016 | PE2s (4 g) | Petroleum ether extract | 250-5003 |
II-14-18 (311.000 mg) | Methyl alcohol elution from PE2s | 12.5-503 | |
II-19-30 (355.100 mg) | 12.5-253 | ||
II-10-13 (306.100 mg) | 25-1003 | ||
II-54-58 (96.000 mg) | 100-400 +3 | ||
II-31-45 (363.900 mg) | 25-503 | ||
II-46-53 (184.500 mg) | 25-1003 | ||
II-59-63 (78.100 mg) | 50-1003 | ||
II-64-78 (425.400 mg) | 100-400 +3 | ||
II-1-6 (215.700 mg) | 50-2003 | ||
II-7-9 (319.900 mg) | 25-2003 | ||
1-(5-chloro-2-hydroxyphenyl)-3-methyl-1-butanone) | Recrystallized from II-10-13 and II-54-58 | 12.5-503 | |
2,5-bis(methoxycarbonyl)terephthalic acid | Recrystallized from II-10-13 and II-54-58 | 6.25-253 | |
Thi My Ngan et al[53], 2021 | fEtOAc (11.040 g) | Culture filtrate-derived ethyl acetate fraction | 1.254 |
mEtOAc (0.091 g) | Mycelium-derived Ethyl acetate fraction | 1.54 | |
mHexane (0.162 g) | Mycelium-derived hexane fraction | 7.54 | |
PS (26.400 g) | Culture filtrate-derived polysaccharide | 7.54 | |
fHexane (0.120 g) | Culture filtrate-derived hexane fraction | 104 | |
mWater (0.509 g) | Mycelium-derived water fraction | 10 +4 | |
fWater (72.480 g) | Culture filtrate-derived water fraction | 10 +4 |
Table 2 Main studies examining antineoplastic mechanisms of Hericium erinaceus against colorectal cancer
Ref. | H. erinaceus fraction employed | Colonic cancer model | Identified mechanism |
Kim et al[119], 2011 | Hot water/ microwave ethanol extraction extracts | CT-26 cancer cells graft in mice | NK cells activity ↑; macrophages activity ↑; angiogenesis ↓ |
Li et al[77], 2014 | Polysaccharides | HT-29 cancer cells graft in mice | - |
Lee et al[65], 2017 | Erinacine A | Cancer cells (HCT-116, DLD1) | PI3K/AKT/mTOR/; p70S6K pathway; ROS ↑ |
Sharif et al[120], 2018 | Ethanolic and methanolic extracts | Cancer cells (HT-29) | α-glucosidase activity ↑; anti-tyrosinase activity ↓ |
Liu et al[116], 2020 | Polysaccharides | Cancer cells (HCT-116) | CDK1 ↓; CDK2 ↓; Cyclin A2 ↓; MCM5 ↓ |
Hou et al[118], 2020 | Polysaccharides | Cancer cells (HCT-116, DLD1) | Clived caspases 3,9 ↑; ROS ↑; Bax ↑; Bcl-2 ↓ |
- Citation: Gravina AG, Pellegrino R, Auletta S, Palladino G, Brandimarte G, D’Onofrio R, Arboretto G, Imperio G, Ventura A, Cipullo M, Romano M, Federico A. Hericium erinaceus, a medicinal fungus with a centuries-old history: Evidence in gastrointestinal diseases. World J Gastroenterol 2023; 29(20): 3048-3065
- URL: https://www.wjgnet.com/1007-9327/full/v29/i20/3048.htm
- DOI: https://dx.doi.org/10.3748/wjg.v29.i20.3048