Systematic Reviews
Copyright ©The Author(s) 2023.
World J Gastroenterol. Apr 14, 2023; 29(14): 2202-2221
Published online Apr 14, 2023. doi: 10.3748/wjg.v29.i14.2202
Table 1 Characteristics of the included studies
Ref.CountryDesignStudy periodStudy population
Early-stage gastric MALT lymphoma, n
Lugano stage
Median follow-up in mo
H. pylori-positive early-stage GML, n
Diagnosis of H. pylori infection
Yang et al[18], 2021ChinaRetrospective2003-201570703052UBT; HE
Schmelz et al[19], 2019GermanyProspective2001-20101091091299HE
Sugizaki et al[20], 2018JapanProspective2010-2016979737.497HE; HpC; RUT; UBT; HpSA; S
Song et al[21], 2018ChinaProspective2000-20131221223847RUT; HE; UBT
Li et al[22], 2016ChinaRetrospective2001-2013757562.969HE; UBT
Kim et al[24], 2016KoreaRetrospective2001-201449495140HE; UBT; RUT
Moleiro et al[23], 2016KoreaRetrospective2005-201410310350.582RUT; UBT; HE
Park et al[25], 2016PortugalRetrospective1993-201310310310587HE; HpC; S; UBT
Grgov et al[26], 2015SerbiaProspective2002-20122020NR20RUT; HE
Nonaka et al[27], 2014JapanRetrospective2007-20121616NR12HE; S; UBT
Lima et al[28], 2014BrazilProspective2009-201088247RUT; HE; UBT
Wündisch et al[29], 2012GermanyProspective1993-1999120120122120HE
Choi et al[30], 2011KoreaRetrospective2003-2010353521.526HE; RUT; UBT
Ono et al[31], 2011JapanRetrospective2003-20092121113RUT; UBT; HpC; HE; S
Andriani et al[32], 2009ItalyRetrospective1993-200660606560HE
Sumida et al[33], 2009JapanProspective1997-200766664057HE; S; UBT
Stathis et al[34], 2009SwitzerlandRetrospective1990-200610510575.685HE; S; UBT
Terai et al[35], 2008JapanProspective1995-200674744670RUT; HE; S; UBT
Fischbach et al[36], 2007GermanyRetrospectiveNR10810842.2108HE; UBT
Kim et al[37], 2007KoreaProspective1996-200699994199HE; RUT
El-Zahabi et al[38], 2007LebanonRetrospective1999-200522221219HE; S
Hong et al[39], 2006KoreaProspective1996-200390904590HE; RUT; UBT
Wündisch et al[40], 2006GermanyRetrospective1993-200319619627196HE
Akamatsu et al[41], 2006JapanProspective1993-2006555537.338HpC; HE
Wündisch et al[42], 2005GermanyProspectiveNR12012075120HE
Montalban et al[43], 2005SpainProspective1993-200224246424HE; UBT
Chen et al[44], 2005TaiwanProspective1996-199934347031HE; RUT; S
Taji et al[45], 2005JapanProspective1995-2001131332.512HE; HpC; S; UBT; RUT
Takenaka et al[46], 2004JapanProspective1995-20023333533HpC; RUT
Fischbach et al[47], 2004GermanyProspectiveNR909044.680RUT; HE; UBT
Sheu et al[48], 2003TaiwanProspectiveNR1515NR15RUT; HE
Caletti et al[49], 2002ItalyProspective1997-199951512451HE; RUT; S
Nakamura et al[50], 2002JapanProspective1994-2001212114.517HpC; S
Liu et al[51], 2002France; Netherlands; Italy; Germany; EnglandRetrospectiveNR111111NR111HE; HpC
Bertoni et al[52], 2002England; Italy; SwitzerlandProspectiveNR62622462HE; S
Ohashi et al[53], 2002JapanProspectiveNR1313NR13RUT; HE; HpC
Kim et al[54], 2002KoreaProspectiveNR202018.320RUT; HE
Matsushima et al[55], 2002JapanProspective1995-1997141427.514RUT; HE; HpC; UBT
Kanda et al[56], 2001JapanProspective1994-19991313713HE
Raderer et al[57], 2001AustriaRetrospective1997-199922222522HE
Nakamura et al[58], 2001JapanProspective1994-1998414120.541HpC; S; HE
Ruskoné-Fourmestraux et al[59], 2001FranceProspective1995-199844443534HE; HpC; S; PCR
Thiede et al[60], 2001GermanyProspectiveNR979720.897NR
de Jong et al[61], 2001NetherlandsProspectiveNR23233723HE; HpC
Urakami et al[62], 2000JapanProspectiveNR47472047RUT; HE; HpC
Papa et al[63], 2000ItalyProspective1995-199977487HE; UBT
Yamashita et al[64], 2000JapanProspectiveNR2121NR21HE; RUT; HpC
Ohashi et al[65], 2000JapanProspectiveNR1111NR11RUT; HE; HpC
Nakamura et al[66], 2000JapanProspective1993-19983030NR26HpC
Savio et al[67], 2000ItalyProspective1991-19977676NR76HE
Weston et al[68], 1999United StatesProspectiveNR6868NR65HE
Steinbach et al[69], 1999United StatesProspectiveNR3434NR28HE; RUT; S
Nobre-Leitão et al[70], 1998PortugalProspectiveNR17171217HE; HpC
Thiede et al[71], 1997GermanyProspectiveNR8484NR84NR
Sackmann et al[72], 1997GermanyProspectiveNR22221022HE; HpC
Neubauer et al[73], 1997GermanyProspectiveNR50502450HE
Pinotti et al[74], 1997Italy; SwitzerlandProspective1986-1995868623.345HE; S
Savio et al[75], 1996Italy; EnglandProspective1991-19931313NR13HE
Bayerdörffer et al[76], 1995GermanyProspectiveNR333312.533HE
Roggero et al[77], 1995Switzerland; ItalyProspectiveNR26261226HE
Wotherspoon et al[78], 1993England; ItalyProspectiveNR66NR6HE
CR: Complete remission rate; GML: Gastric mucosa-associated lymphoid tissue lymphoma; H. pylori: Helicobacter pylori; HE: Histologic examination; HpC: Helicobacter pylori culture; HpSA: Helicobacter pylori stool antigen; MALT: Mucosa-associated lymphoid tissue; NR: Not reported; PPI: Proton pump inhibitor; RUT: Rapid urease test; S: Serology; UBT: 13C- or 14C-urea breath test.
Table 2 Characteristics of studies reporting the complete remission rate of Helicobacter pylori-positive early-stage gastric mucosa-associated lymphoid tissue lymphoma after bacterial eradication
Ref.
Region
H. pylori-positive early-stage gastric MALT lymphoma, n
H. pylori-eradicated gastric MALT lymphoma patients, n
CR, n
t(11;18)(q21;q21)-investigated gastric MALT lymphoma, n
t(11;18)(q21;q21)-positive gastric MALT lymphoma, n
Eradication regimen
Yang et al[18]Asian524838NRNR7-d-14-d triple therapy or 10-d quadruple therapy
Schmelz et al[19]Western9999666977-d triple therapy
Sugizaki et al[20]Asian9786847317-d triple therapy
Song et al[21]Asian474735NRNR14-d triple therapy
Li et al[22]Asian696954NRNRND-day quadruple therapy
Kim et al[24]Asian403535NRNR7-d-14-d triple therapy or 7-d-14-d bismuth quadruple therapy
Moleiro et al[23]Western828177NRNR7-d triple therapy or 7-d bismuth quadruple therapy
Park et al[25]Asian878173NRNR7-d-14-d triple therapy
Grgov et al[26]Western202017NRNR10-d triple therapy
Nonaka et al[27]Asian12129NRNR7-d triple therapy
Lima et al[28]Western775847-d triple therapy or 10-d triple therapy
Wündisch et al[29]Western12012096661014-d dual therapy or 10-d triple therapy
Choi et al[30]Asian262622NRNRND-day triple therapy or ND-day bismuth quadruple therapy
Ono et al[31]Asian131313NRNR7-d-triple therapy
Andriani et al[32]Western605342NRNR7-d-14-d triple therapy or 10-d bismuth quadruple therapy
Sumida et al[33]Asian5757476677-d triple therapy
Stathis et al[34]Western858566NRNRND-day triple therapy
Terai et al[35]Asian7070562207-d triple therapy
Fischbach et al[36]Western10810835NRNRNR
Kim et al[37]Asian999984NRNR7-d triple therapy or 7-d bismuth quadruple therapy
El-Zahabi et al[38]Asian19198NRNRND-day quadruple therapy
Hong et al[39]Asian909085NRNR14-d triple therapy or 14-d bismuth quadruple therapy
Wündisch et al[40]Western196193146NRNRNR
Akamatsu et al[41]Asian383829867-d triple therapy or ND-day quadruple therapy
Wündisch et al[42]Western12012096651014-d dual therapy or 10-d triple therapy
Montalban et al[43]Western242422NRNR14-d triple therapy
Chen et al[44]Asian313024NRNR14-d triple therapy
Taji et al[45]Asian1212713414-d triple therapy
Takenaka et al[46]Asian333126NRNRND-day triple therapy
Fischbach et al[47]Western808056NRNR7-d triple therapy
Sheu et al[48]Asian151511NRNR14-d triple therapy
Caletti et al[49]Western514525NRNR7-d triple therapy
Nakamura et al[50]Asian1717223714-d triple therapy
Liu et al[51]Western111111481114414-d dual therapy
Bertoni et al[52]Western626246NRNR7-d triple therapy; 14-d triple therapy or 14-d bismuth quadruple therapy
Ohashi et al[53]Asian131311NRNR14-d triple therapy
Kim et al[54]Asian202018NRNR7-d triple therapy or 7-d bismuth quadruple therapy
Matsushima et al[55]Asian141410NRNRND-day triple therapy
Kanda et al[56]Asian13129NRNRND-day dual therapy or ND-day triple therapy
Raderer et al[57]Western222115NRNRND-day dual therapy or ND-day triple therapy
Nakamura et al[58]Asian414129NRNRND-day triple or ND-day quadruple therapy
Ruskoné-Fourmestraux et al[59]Western343419NRNR14-d triple therapy
Thiede et al[60]Western979777NRNR14-d dual therapy or 7-d triple therapy
de Jong et al[61]Western232313NRNRND-day dual therapy; ND-day triple therapy or ND-day quadruple therapy
Urakami et al[62]Asian474442NRNR7-d-14-d triple therapy
Papa et al[63]Western777NRNR7-d triple therapy
Yamashita et al[64]Asian212114NRNR14-d triple therapy
Ohashi et al[65]Asian11119NRNR14-d triple therapy
Nakamura et al[66]Asian262513NRNR14-d dual therapy; 7-d triple therapy (14-d PPI); 14-d triple therapy
Savio et al[67]Western767671NRNRNR
Weston et al[68]Western655838NRNRND-day triple or ND-day quadruple therapy
Steinbach et al[69]Western282814NRNR21-d bismuth quadruple therapy
Nobre-Leitão et al[70]Western171717NRNR14-d triple therapy
Thiede et al[71]Western847968NRNRNR-day-dual or 7-d-triple therapy
Sackmann et al[72]Western222212NRNR14-d-dual therapy
Neubauer et al[73]Western505040NRNR14-d-dual therapy or 7-d-triple therapy
Pinotti et al[74]Western454430NRNR14-d-triple or quadruple therapy
Savio et al[75]Western131211NRNRNR-day-triple or quadruple therapy
Bayerdörffer et al[76]Western333323NRNR14-d-dual therapy
Roggero et al[77]Western26255NRNR14-d-triple therapy
Wotherspoon et al[78]Western665NRNRNR-day-dual or triple therapy
CR: Complete remission rate; H. pylori: Helicobacter pylori; MALT: Mucosa-associated lymphoid tissue; NR: Not reported; PPI: Proton pump inhibitor.
Table 3 Meta-regression according to selected covariates
Subgroup
Studies, n
Estimate
95%CI
P value
I2, %
Year
≤ 201554---92.5
> 201570.11-0.03 to 0.250.1188
Region92.8
Asian29---
Western32-0.06-0.15 to 0.030.2145
Proportion of patients with t(11;18)(q21;q21)-positive gastric MALT lymphoma
≤ 30%7
> 30%4-0.40-0.59 to -0.22< 0.000188.6
Risk of bias92.3
Low39---
Moderate210.02-0.07 to 0.120.6190
High1-0.43-0.77 to -0.090.0139
MALT: Mucosa-associated lymphoid tissue.
  • Citation: Lemos FFB, Castro CT, Calmon MS, Silva Luz M, Pinheiro SLR, Faria Souza Mendes dos Santos C, Correa Santos GL, Marques HS, Delgado HA, Teixeira KN, Souza CL, Oliveira MV, Freire de Melo F. Effectiveness of Helicobacter pylori eradication in the treatment of early-stage gastric mucosa-associated lymphoid tissue lymphoma: An up-to-date meta-analysis. World J Gastroenterol 2023; 29(14): 2202-2221
  • URL: https://www.wjgnet.com/1007-9327/full/v29/i14/2202.htm
  • DOI: https://dx.doi.org/10.3748/wjg.v29.i14.2202