Copyright
©The Author(s) 2023.
World J Gastroenterol. Apr 14, 2023; 29(14): 2172-2187
Published online Apr 14, 2023. doi: 10.3748/wjg.v29.i14.2172
Published online Apr 14, 2023. doi: 10.3748/wjg.v29.i14.2172
Table 1 Clinical data from patients with Crohn’s disease and healthy subjects
Group Ia (n = 50) | Group Ib (n = 16) | Group II (n = 39) | Control (n = 40) | |
General characteristics | ||||
Male:Female (ratio) | 29:21 (1.38) | 8:8 (1) | 22:17 (1.29) | 15:25 (0.6) |
Age (years), mean ± SD | 13 ± 2.9 | 15 ± 2.8 | 12.5 ± 4.3 | 11 ± 4.1 |
BMI (kg/m2), mean ± SD | 17.0 ± 3.1 | 18.1 ± 2.7 | 18.1 ± 3.2 | 18.3 ± 3.8 |
PCDAI, mean ± SD | 34.4 ± 12.7 | 38.2 ± 18.6 | 4.1 ± 3.9 | N/A |
Disease distribution by Paris classification (number of patients) | ||||
A1a | 4 | 2 | 7 | |
A1b | 46 | 14 | 30 | |
A2 | 0 | 2 | 2 | |
L1 | 2 | 1 | 2 | |
L2 | 6 | 2 | 7 | |
L3 | 16 | 4 | 12 | |
L4aL1 | 8 | 2 | 6 | |
L4aL2 | 8 | 3 | 5 | |
L4aL3 | 10 | 4 | 7 | |
B1 | 39 | 11 | 27 | |
B2 | 11 | 5 | 12 |
Table 2 Alpha diversity metrics P values at the phylum (L2) and species (L7) level, expressed as Shannon, Chao and Fisher indices
Index/group | Shannon | Chao | Fisher | |||
L2 level | L7 level | L2 level | L7 level | L2 level | L7 level | |
Ia vs Ib | 0.713 | 0.251 | 0.836 | 0.121 | 0.533 | 0.312 |
Ia vs II | 0.606 | 0.584 | 0.228 | 0.001a | 0.000a | 0.011a |
Ia vs control | 0.000a | 0.313 | 0.006a | 0.000a | 0.000a | 0.000a |
Ib vs II | 0.492 | 0.128 | 0.356 | 0.185 | 0.132 | 0.041a |
Ib vs control | 0.072 | 0.053 | 0.103 | 0.077 | 0.072 | 0.027a |
II vs control | 0.086 | 0.710 | 0.044a | 0.631 | 0.998 | 0.938 |
Table 3 Beta diversity metrics P values at the phylum (L2) and species (L7) level, expressed as Bray-Curtis, Jensen-Shanon and Jaccard indices
Index/group | Bray-Curtis | Jensen-Shannon | Jaccard | |||
L2 level | L7 level | L2 level | L7 level | L2 level | L7 level | |
Ia vs Ib | 0.753 | 0.727 | 0.746 | 0.92 | 0.813 | 0.632 |
Ia vs II | 0.409 | 0.291 | 0.404 | 0.176 | 0.469 | 0.389 |
Ia vs control | 0.038a | 0.006a | 0.009a | 0.001a | 0.035a | 0.008a |
Ib vs II | 0.532 | 0.374 | 0.543 | 0.468 | 0.517 | 0.332 |
Ib vs control | 0.172 | 0.086 | 0.125 | 0.064 | 0.15 | 0.094 |
II vs control | 0.313 | 0.057 | 0.206 | 0.026a | 0.393 | 0.087 |
Table 4 Correlations of fungal species with patient parameters
Variables/age | Variables/calprotectin | Variables/PCDAI | |||
Debaryomyces hansenii | P < 0.008 | Candida dubliniensis | P < 0.003 | Candida tropicalis | P < 0.006 |
r = -0.08 | r = 0.29 | r = 0.58 | |||
Candida zeylanoides | P < 0.004 | Candida sake | P < 0.04 | ||
r = 0.08 | r = 0.19 |
- Citation: Krawczyk A, Salamon D, Kowalska-Duplaga K, Zapała B, Książek T, Drażniuk-Warchoł M, Gosiewski T. Changes in the gut mycobiome in pediatric patients in relation to the clinical activity of Crohn's disease. World J Gastroenterol 2023; 29(14): 2172-2187
- URL: https://www.wjgnet.com/1007-9327/full/v29/i14/2172.htm
- DOI: https://dx.doi.org/10.3748/wjg.v29.i14.2172