Copyright ©The Author(s) 2022.
World J Gastroenterol. Feb 7, 2022; 28(5): 517-531
Published online Feb 7, 2022. doi: 10.3748/wjg.v28.i5.517
Table 1 New antiviral drugs for hepatitis B

Mechanism of action
Entry inhibitorsBulevirtide (Myrcludex B)Block HBV entry into hepatocytes to protect cells not yet infected or antagonize de novo infection[16,17]
Capsid assembly modulatorsNVR 3-788; GLS4; RO7049389; JNJ-6379; JNJ-0440; ABI-H0731Inhibition of nucleocapsid formation[19-24]
Post-transcriptional inhibitorsARC-520; ARC-521; ARB-1467Induction mRNA degradation after transcription and translation prevention[27,28]
Inhibitors of HBsAg releaseREP 2165; LenvervimabRemoval of subviral envelope particle. Neutralization activity[29-31]
Inhibitors of cccDNACRISP-Cas systemDisablement of cccDNA[32-34]