Copyright ©The Author(s) 2022.
World J Gastroenterol. Dec 21, 2022; 28(47): 6689-6701
Published online Dec 21, 2022. doi: 10.3748/wjg.v28.i47.6689
Table 1 Alterations of the gut microbiota composition in coronavirus disease 2019 patients
Increased abundance of gut microbiota
Decreased abundance of gut microbiota
Main conclusion
Gu et al[15], 202016S rrnaStreptococcus, Rothia, Veillonella, Actinomyces, ErysipelatoclostridiumRuminococcaceae family, Lachnospiraceae family, Agathobacter, Fusicatenibacter, RoseburiaGut microbiota has potential value as a diagnostic biomarker and therapeutic target for COVID-19
Zuo et al[10], 2020ShotgunClostridium hathewayi, Actinomyces viscosus, Bacteroides nordiiEubacterium, Faecalibacterium prausnitzii, Roseburia, LachnospiraceaeFecal microbiota alterations are associated with fecal virus levels and COVID-19 severity; symbionts were depletion and opportunistic pathogens were enrichment in COVID-19 patients; gut dysbiosis persists in COVID-19 patients after virus clearance
Tao et al[16], 202016S rrnaStreptococcus, Clostridium, Lactobacillus, BifidobacteriumBacteroidetes, Roseburia, Faecalibacterium, Coprococcus, ParabacteroidesIL-18 level was higher in the fecal samples from COVID-19 patients; dysbiosis may contribute to SARS-CoV-2-induced production of inflammatory cytokines and cytokine storm in the gut
Tang et al[17], 2020Q-PCREnterococcus, EnterobacteriaceaeFaecalibacterium prausnitzii, Clostridium butyricum, Clostridium leptum, Eubacterium rectaleSpecific gut microbiota can be considered diagnostic biomarkers for COVID-19; the Ec/E ratio can be used to predict death in critically ill patients
Zuo et al[18], 2020ShotgunCandida albicans, Candida auris, Aspergillus flavus-The guts of COVID-19 patients are accompanied by massive fungal blooms
Yeoh et al[12], 2021ShotgunActinobacteria, Ruminococcus gnavus, Ruminococcus torques, Bacteroides doreiBifidobacterium adolescentis, Faecalibacterium prausnitzii, Eubacterium rectaleImmunomodulatory gut bacteria were depleted in COVID-19 patients; gut dysbiosis persists in COVID-19 patients after virus clearance; gut microbiota composition was associated with disease severity
Wu et al[19], 202116S rrnaStreptococcus, Weissella, Enterococcus, Rothia, Lactobacillus, Actinomyces, GranulicatellaBlautia, Coprococcus, CollinsellaPersonalized microbiome affects disease outcomes in COVID-19 patients; targeting the gut microbiota has potential to prevent and treat COVID-19
Zuo et al[20], 2021ShotgunCollinsella aerofaciens, Collinsella tanakaei, Streptococcus infantis, Morganella morganiiParabacteroides merdae, Bacteroides stercoris,Alistipes onderdonkii, Lachnospiraceae bacterium 1_1_57FAAElimination of gut SARS-CoV-2 activity and modulation of gut microbiome composition should be considered new treatments for COVID-19; the 3’ end of SARS-CoV-2 genome was highly covered than the 5’ end
Lv et al[21], 2021ITS sequencing-Ascomycota (Aspergillaceae, Candida parapsilosis, Talaromyces wortmannii); Basidiomycota (Malassezia yamatoensis, Rhodotorula mucilaginosa, Moesziomyces aphidis, Trechispora sp. and Wallemia sebi)Total gut fungal burden was significantly elevated in patients infected with SARS- CoV-2; altered gut fungi and microbiota are closely related to patient clinical characteristics
Suskun et al[22], 202216S rrnaBifidobacterium adolescentis, Dorea formicigenerasus, Eubacterium dolichum, Eggerthella lentaFaecalibacterium prausnitziiFirst evaluate the microbiota composition in multisystem inflammatory syndrome in children cases