Copyright
©The Author(s) 2022.
World J Gastroenterol. Sep 21, 2022; 28(35): 5188-5202
Published online Sep 21, 2022. doi: 10.3748/wjg.v28.i35.5188
Published online Sep 21, 2022. doi: 10.3748/wjg.v28.i35.5188
Table 1 Basic information and clinical characteristics of healthy individuals, immune-tolerant phase hepatitis B virus infection patients, and immune-active phase hepatitis B virus infection patients
Characteristic | H, n = 13 | IT, n = 14 | IA, n = 10 | P value |
Sex, M/F | 9/4 | 9/5 | 7/3 | 0.949 |
Age in yr | 26.4 ± 0.8 | 26.9 ± 5.8 | 36.2 ± 11.3 | 0.004 |
HBsAg as log10 IU/mL | NA | 4.62 ± 0.18 | 3.83 ± 0.81 | < 0.001 |
HBeAg as log10 S/Co | NA | 3.18 ± 0.08 | 1.21 ± 1.70 | < 0.001 |
HBV DNA as log10 IU/mL | NA | 7.81 ± 0.80 | 6.28 ± 1.70 | < 0.001 |
AFP in ng/mL | 2.06 ± 0.82 | 2.49 ± 1.05 | 22.61 ± 40.82 | 0.045 |
TBIL in μmol/L | 5.9 ± 3.1 | 12.7 ± 5.3 | 19.5 ± 9.2 | < 0.001 |
ALB in g/L | 48.8 ± 3.5 | 45.8 ± 2.9 | 43.0 ± 4.9 | 0.002 |
GLO in g/L | 24.4 ± 4.0 | 26.6 ± 4.4 | 29.3 ± 4.3 | 0.017 |
ALT in U/L | 22.0 (18.0, 29.0) | 29.5 (23.7, 33.0) | 277.5 (101.5, 410.8) | < 0.001 |
AST in U/L | 16.0 (12.0, 22.0) | 23.0 (19.5, 27.8) | 111.0 (67.0, 143.5) | 0.006 |
GGT in U/L | 25.7 ± 11.5 | 18.5 ± 9.4 | 72.7 ± 64.9 | 0.001 |
TBA in μmol/L | 2.3 (1.9, 3.4) | 5.6 (4.2, 8.4) | 13.9 (5.5, 31.1) | 0.012 |
LSM in kPa | 4.99 ± 0.99 | 5.11 ± 1.01 | 6.38 ± 0.72 | 0.026 |
Table 2 Species richness indices in the fecal samples
Group | Healthy controls, n = 14 | IT phase HBV infection, n = 13 | IA phase HBV infection, n = 10 | P value |
OTUs | 633 | 662 | 489 | |
α-diversity indexes, median | ||||
Chao1 | 264.310 | 233.825 | 227.000 | 0.924 |
Shannon | 5.020 | 4.720 | 4.705 | 1.739 |
Simpson | 0.940 | 0.885 | 0.915 | 1.666 |
- Citation: Li YN, Kang NL, Jiang JJ, Zhu YY, Liu YR, Zeng DW, Wang F. Gut microbiota of hepatitis B virus-infected patients in the immune-tolerant and immune-active phases and their implications in metabolite changes. World J Gastroenterol 2022; 28(35): 5188-5202
- URL: https://www.wjgnet.com/1007-9327/full/v28/i35/5188.htm
- DOI: https://dx.doi.org/10.3748/wjg.v28.i35.5188