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©The Author(s) 2022.
World J Gastroenterol. Sep 7, 2022; 28(33): 4834-4845
Published online Sep 7, 2022. doi: 10.3748/wjg.v28.i33.4834
Published online Sep 7, 2022. doi: 10.3748/wjg.v28.i33.4834
All IBD patients (n = 301) | |
Female sex | 190 (63.1%) |
Age (yr) | 47.6 ± 17.4 |
Ethnicity | |
Caucasian | 230 (76.4%) |
Hispanic | 16 (5.3%) |
African-American | 5 (1.7%) |
Asian | 14 (4.7%) |
Not specified | 36 (12.0%) |
BMI | 24.8 ± 5.2 |
Obesity (BMI ≥ 30)1 | 42 (14.4%) |
Active smoking | 6 (2.0%) |
CD | 201 (66.8%) |
Disease location | |
Ileal | 57 (28.4%) |
Colonic | 34 (16.9%) |
Ileocolonic | 108 (53.7%) |
Upper disease | 10 (5.0%) |
Behavior | |
Non-stricturing, non-penetrating | 106 (52.7%) |
Stricturing | 74 (36.8%) |
Penetrating | 47 (23.4%) |
UC | 100 (36.8%) |
Disease location1 | |
Proctitis | 14 (14.7%) |
Left-sided colitis | 45 (47.4%) |
Pancolitis | 36 (37.9%) |
Disease duration (yr) | 17.0 ± 13.6 |
IBD related surgery | 109 (36.2%) |
IBD medications | |
Current biologic use | 133 (44.2%) |
Past/ever biologic use | 166 (55.1%) |
Clinically active disease1 | 134 (45.9%) |
CD | 96 (49.2%) |
UC | 38 (39.2%) |
Endoscopically severe disease1 | 20 (17.7%) |
CD | 12 (15.6%) |
UC | 8 (22.2%) |
Covariates | Prevalence of vitamin C deficiency in patients with covariate | Prevalence of vitamin C deficiency in patients without covariate | P value |
IBD type | |||
CD | 49/201 (24.4%) | - | 0.1 |
UC | 16/100 (16.0%) | - | 0.1 |
Small bowel disease | 38/165 (23.0%) | 11/36 (30.6%) | 0.3 |
Penetrating disease | 17/47 (36.2%) | 32/154 (20.8%) | 0.031 |
IBD related surgery | 28/109 (25.7%) | 37/192 (19.3%) | 0.2 |
CD | 25/96 (26.0%) | 24/105 (22.9%) | 0.6 |
UC | 3/13 (23.1%) | 13/87 (14.9%) | 0.4 |
Obesity (BMI ≥ 30) | 15/42 (35.7%) | 49/249 (19.7%) | 0.021 |
Active smoking | 3/6 (50.0%) | 62/295 (21.0%) | 0.1 |
Current biologic use | 38/133 (28.6%) | 26/167 (15.6%) | 0.0061 |
CRP > 0.9 mg/dL | 25/64 (39.1%) | 36/213 (16.9%) | < 0.0011 |
CD | 21/51 (41.2%) | 24/134 (17.9%) | 0.0011 |
UC | 4/13 (30.8%) | 12/79 (15.2%) | 0.2 |
Fecal calprotectin > 250 ug/g | 10/20 (50.0%) | 12/60 (20.0%) | 0.0091 |
CD | 9/16 (56.3%) | 10/38 (26.3%) | 0.041 |
UC | 1/4 (25.0%) | 2/22 (9.1%) | 0.4 |
Iron deficiency | 17/59 (28.8%) | 39/193 (20.2%) | 0.2 |
Vitamin D deficiency/insufficiency | 11/38 (28.9%) | 47/221 (21.3%) | 0.3 |
Clinically active disease | 35/134 (26.1%) | 29/158 (18.4%) | 0.1 |
CD | 29/96 (30.2%) | 20/99 (20.2%) | 0.1 |
UC | 6/38 (15.8%) | 9/59 (15.3%) | 0.9 |
Endoscopically severe disease | 7/20 (35.0%) | 21/93 (22.6%) | 0.2 |
CD | 5/12 (41.7%) | 18/65 (27.7%) | 0.3 |
UC | 2/8 (25.0%) | 3/28 (10.7%) | 0.3 |
Vitamin C deficiency (n = 65) | Normal vitamin C level (n = 236) | P value | |
Presence of ≥ 1 clinical feature(s) of scurvy | 43 (66.2%) | 138 (58.5%) | 0.3 |
None | 22 (33.8%) | 98 (41.5%) | - |
Fatigue | 28 (43.1%) | 65 (27.5%) | 0.021 |
Arthritis/arthralgias | 27 (41.5%) | 96 (40.7%) | 0.9 |
Skin findings (rash, hyperpigmentation) | 9 (13.8%) | 29 (12.3%) | 0.7 |
Easy bruising | 6 (9.2%) | 9 (3.8%) | 0.1 |
Gingivitis | 3 (4.6%) | 6 (2.5%) | 0.4 |
Poor wound healing | 3 (4.6%) | 1 (0.4%) | 0.031 |
Perifollicular findings (hemorrhage, folliculitis) | 2 (3.1%) | 1 (0.4%) | 0.1 |
Alopecia | 1 (1.5%) | 5 (2.1%) | 1.0 |
- Citation: Gordon BL, Galati JS, Yang S, Longman RS, Lukin D, Scherl EJ, Battat R. Prevalence and factors associated with vitamin C deficiency in inflammatory bowel disease. World J Gastroenterol 2022; 28(33): 4834-4845
- URL: https://www.wjgnet.com/1007-9327/full/v28/i33/4834.htm
- DOI: https://dx.doi.org/10.3748/wjg.v28.i33.4834