Shao J, Lu HC, Wu LQ, Lei J, Yuan RF, Shao JH. Simple cholecystectomy is an adequate treatment for grade I T1bN0M0 gallbladder carcinoma: Evidence from 528 patients. World J Gastroenterol 2022; 28(31): 4431-4441 [PMID: 36159006 DOI: 10.3748/wjg.v28.i31.4431]
Corresponding Author of This Article
Jiang-Hua Shao, MD, PhD, Chief Doctor, Full Professor, Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Nanchang University, No. 1 Minde Road, Nanchang 330006, Jiangxi Province, China. shao5022@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Observational Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Aug 21, 2022; 28(31): 4431-4441 Published online Aug 21, 2022. doi: 10.3748/wjg.v28.i31.4431
Table 1 General characteristics and survival data for 528 patients with T1b gallbladder cancer
Characteristics
n = 528, n (%)
10-year survival
OS, %
DSS, %
Age, yr
< 70
220 (41.7)
46.4%
62.7%
≥ 70
308 (58.3)
21.9%
58.9%
P < 0.001
P = 0.023
Gender
Male
143 (27.1)
13.7
47.5
Female
385 (72.9)
37.8
64
P = 0.007
P = 0.016
Grade
Grade I
161 (30.5)
33.1
64.7
Grade II
269 (50.9)
32.6
62.1
Grade III, IV
98 (18.6)
28.6
48.9
P = 0.056
P = 0.002
Histological type
Adenocarcinoma
387 (73.3)
30.5
61.6
Papillary
79 (15.0)
40.2
61.8
Other
62 (11.7)
29
51
P = 0.059
P = 0.058
Surgery
SC
346 (65.5)
27.8
55.1
SC + LN
131 (24.8)
35.5
66.3
RC
51 (9.7)
50.3
75.9
P < 0.001
P = 0.002
Table 2 Multivariate Cox proportional hazards model for 10-year overall survival and disease-specific survival in 528 patients with T1b gallbladder cancer
Variable
10-year overall survival
10-year disease-specific survival
HR (95%CI)
P value
HR (95%CI)
P value
Age, yr
< 70
Referent
Referent
≥ 70
2.03 (1.57-2.63)
< 0.001
NA
NA
Gender
Male
Referent
Referent
Female
0.71 (0.55-0.91)
0.007
0.62 (0.45-0.87)
0.005
Grade
Grade I
Referent
Referent
Grade II
NA
NA
1.21 (0.83-1.76)
0.321
Grade III, IV
NA
NA
2.20 (1.43-3.38)
< 0.001
Histological type
Adenocarcinoma
Referent
Referent
Papillary
NA
NA
NA
NA
Other
NA
NA
NA
NA
Surgery
SC
Referent
Referent
SC + LN
0.71 (0.53-0.95)
0.020
0.56 (0.37-0.83)
0.004
RC
0.54 (0.32-0.89)
0.015
0.49 (0.27-0.92)
0.025
Table 3 General characteristics and survival data for 161 patients with grade I T1b gallbladder cancer
Table 4 Multivariate Cox proportional hazards model for 10-year overall survival and disease-specific survival in 161 patients with grade I T1b gallbladder cancer
Variable
10-year overall survival
10-year disease-specific survival
HR (95%CI)
P value
HR (95%CI)
P value
Age, yr
< 70
Referent
Referent
≥ 70
1.67 (1.07-2.59)
0.023
NA
NA
Gender
Male
Referent
Referent
Female
0.62 (0.40-0.96)
0.031
NA
NA
Histological type
Adenocarcinoma
Referent
Referent
Papillary
NA
NA
NA
NA
Other
NA
NA
NA
NA
Surgery
SC
Referent
Referent
SC + LN
NA
NA
NA
NA
RC
NA
NA
NA
NA
Citation: Shao J, Lu HC, Wu LQ, Lei J, Yuan RF, Shao JH. Simple cholecystectomy is an adequate treatment for grade I T1bN0M0 gallbladder carcinoma: Evidence from 528 patients. World J Gastroenterol 2022; 28(31): 4431-4441