Alterations of autophagic and innate immune responses by the Crohn’s disease-associated ATG16L1 mutation

Table 1 Physiological functions of autophagy related 16 like 1

Function	Cell type	Ref.
Positive regulation
Autophagy	ECs, DCs, macrophages	[9,10]
Regulatory T cell responses	DCs	[22]
Negative regulation
IFN-I production by RLRs	MEFs	[11,12]
IFN-I production by TLR3 and TLR4	Macrophages	[13]
IL-1β production by TLR4	Macrophages	[16,17,19]
IL-6 and IL-12 production by TLR2	DCs	[27]

EC: Epithelial cell; DC: Dendritic cell; IFN-I: Type I interferon; RLR: Retinoic acid-inducible gene I-like receptors; MEF: Mouse embryonic fibroblast; TLR: Toll-like receptor; IL: Interleukin.