Sinapic acid ameliorates D-galactosamine/lipopolysaccharide-induced fulminant hepatitis in rats: Role of nuclear factor erythroid-related factor 2/heme oxygenase-1 pathways

doi:10.3748/wjg.v27.i7.592

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Feb 21, 2021; 27(7): 592-608
Published online Feb 21, 2021. doi: 10.3748/wjg.v27.i7.592

Table 1 Effect of sinapic acid pretreatment on liver function serum markers in D-galactosamine/lipopolysaccharide-induced acute liver failure

Serum	Control	D-GalN/LPS	SA 20 mg/kg + D-GalN/LPS	SA 40 mg/kg + D-GalN/LPS
Total protein (mg/dL)	121.98 ± 1.45	82.48 ± 1.84	92.70 ± 1.17^a^,^b	104.96 ± 2.24^a^,^b
AST (U/L)	85.78 ± 3.26	749.83 ± 36.99	417.67 ± 23.46^a^,^b	197.50 ± 18.25^a^,^b
ALT (U/L)	60.75 ± 4.18	963.33 ± 45.73	463.00 ± 22.41^a^,^b	292.33 ± 23.76^a^,^b
Bilirubin (mg/dL)	0.35 ± 0.04	1.66 ± 0.15	0.85 ± 0.03^a^,^b	0.73 ± 0.02^a^,^b

The results are presented as the mean ± SE of six animals per group.

^aDenotes significant differences to the in D-galactosamine/lipopolysaccharide–induced acute liver failure group (P < 0.05).

^bDenotes significant differences to the normal control. SA: Sinapic acid; D-GalN/LPS: D-galactosamine/lipopolysaccharide; ALT: Alanine transaminase; AST: Aspartate aminotransferase.

Citation: Ansari MA, Raish M, Bin Jardan YA, Ahmad A, Shahid M, Ahmad SF, Haq N, Khan MR, Bakheet SA. Sinapic acid ameliorates D-galactosamine/lipopolysaccharide-induced fulminant hepatitis in rats: Role of nuclear factor erythroid-related factor 2/heme oxygenase-1 pathways. World J Gastroenterol 2021; 27(7): 592-608
URL: https://www.wjgnet.com/1007-9327/full/v27/i7/592.htm
DOI: https://dx.doi.org/10.3748/wjg.v27.i7.592