Sinapic acid ameliorates D-galactosamine/lipopolysaccharide-induced fulminant hepatitis in rats: Role of nuclear factor erythroid-related factor 2/heme oxygenase-1 pathways

Table 1 Effect of sinapic acid pretreatment on liver function serum markers in D-galactosamine/lipopolysaccharide-induced acute liver failure

Serum	Control	D-GalN/LPS	SA 20 mg/kg + D-GalN/LPS	SA 40 mg/kg + D-GalN/LPS
Total protein (mg/dL)	121.98 ± 1.45	82.48 ± 1.84	92.70 ± 1.17a,b	104.96 ± 2.24a,b
AST (U/L)	85.78 ± 3.26	749.83 ± 36.99	417.67 ± 23.46a,b	197.50 ± 18.25a,b
ALT (U/L)	60.75 ± 4.18	963.33 ± 45.73	463.00 ± 22.41a,b	292.33 ± 23.76a,b
Bilirubin (mg/dL)	0.35 ± 0.04	1.66 ± 0.15	0.85 ± 0.03a,b	0.73 ± 0.02a,b

The results are presented as the mean ± SE of six animals per group.

^aDenotes significant differences to the in D-galactosamine/lipopolysaccharide–induced acute liver failure group (P < 0.05).

^bDenotes significant differences to the normal control. SA: Sinapic acid; D-GalN/LPS: D-galactosamine/lipopolysaccharide; ALT: Alanine transaminase; AST: Aspartate aminotransferase.