Microarray analysis to explore the effect of CXCL12 isoforms in a pancreatic pre-tumor cell model

Table 1 Detailed statistical results of CXCL12 differential expression analysis in pancreatic ductal adenocarcinoma (mean ± SD)

Group	Number	Minimum	Maximum	Median	IQR	Lower quartile	Upper quartile	Mean		SE
Normal	171	0	7.296	5.433	0.756	5.028	5.784	5.403	0.88	0.067
Tumor	179	1.333	7.629	4.632	2.134	3.727	5.861	4.803	1.445	0.108

IQR: Interquartile distance; SE: Standard error.

Table 2 Detailed information on the correlation between CXCL12 expression and immune cell infiltration

Gene	Cell	Correlation coefficient (Pearson)	P value (Pearson)	Correlation coefficient (Spearman)	P value (Spearman)
CXCL12	aDC	0.355	< 0.001	0.350	< 0.001
CXCL12	B cells	0.614	< 0.001	0.610	< 0.001
CXCL12	CD8 T cells	0.508	< 0.001	0.491	< 0.001
CXCL12	Cytotoxic cells	0.674	< 0.001	0.650	< 0.001
CXCL12	DC	0.668	< 0.001	0.658	< 0.001
CXCL12	Eosinophils	0.488	< 0.001	0.480	< 0.001
CXCL12	iDC	0.639	< 0.001	0.654	< 0.001
CXCL12	Macrophages	0.488	< 0.001	0.487	< 0.001
CXCL12	Mast cells	0.635	< 0.001	0.634	< 0.001
CXCL12	Neutrophils	0.554	< 0.001	0.535	< 0.001
CXCL12	NK CD56bright cells	-0.411	< 0.001	-0.397	< 0.001
CXCL12	NK CD56dim cells	0.376	< 0.001	0.369	< 0.001
CXCL12	NK cells	0.566	< 0.001	0.560	< 0.001
CXCL12	pDC	0.558	< 0.001	0.546	< 0.001
CXCL12	T cells	0.682	< 0.001	0.666	< 0.001
CXCL12	T helper cells	0.511	< 0.001	0.504	< 0.001
CXCL12	Tcm	0.337	< 0.001	0.285	< 0.001
CXCL12	Tem	0.483	< 0.001	0.481	< 0.001
CXCL12	TFH	0.668	< 0.001	0.645	< 0.001
CXCL12	Tgd	0.364	< 0.001	0.472	< 0.001
CXCL12	Th1 cells	0.594	< 0.001	0.605	< 0.001
CXCL12	Th17 cells	0.057	0.453	0.065	0.387
CXCL12	Th2 cells	0.069	0.357	0.032	0.675
CXCL12	TReg	0.493	< 0.001	0.482	< 0.001

aDC: Activated DC; DC: Dendritic cells; iDC: immature DC; pDC: Plasmacytoid DC; Tfh: T follicular helper; Tgd: T gamma delta; NK: Natural killer.