Real-world local recurrence rate after cold polypectomy in colorectal polyps less than 10 mm using propensity score matching

Table 1 Characteristics of excised polyps before propensity score matching

	CP, mean ± SD or n (%)	HP, mean ± SD or n (%)	P-value
Number of polyps resected	706	253
Size, mm	3.82 ± 1.49	5.35 ± 1.77	< 0.001a
Morphology			< 0.001b
Sessile	268 (38.0)	143 (56.5)
Flat	438 (62.0)	110 (43.5)
Location			0.439b
Cecum	46 (6.5)	15 (5.9)
Ascending colon	182 (25.8)	59 (23.3)
Transverse colon	220 (31.2)	58 (22.9)
Descending colon	92 (13.0)	33 (13.0)
Sigmoid colon	128 (18.1)	67 (26.5)
Rectum	38 (5.4)	21 (8.3)
Polypectomy device			< 0.001b
Snare	611 (86.5)	251 (99.2)
Biopsy forceps	95 (13.5)	2 (0.8)

^a Welch test.

^b Chi-Square test.

CP: Cold polypectomy; HP: Hot polypectomy.

Table 2 Characteristics of patients after propensity score matching

	mean ± SD, (%)
	n = 206
Male/female	139 (67.5)/67 (32.5)
Age, yr	68.7 ± 8.6
Range	46-85
Antithrombotic agent users	40 (19.4)
Indication for colonoscopy
Screening	186 (90.3)
Constipation	9 (4.3)
Abdominal pain	6 (2.9)
Bloody stools	2 (1.0)
Anemia	2 (1.0)
Others	1 (0.5)

Table 3 Characteristics of excised polyps after propensity score matching

	CP, mean ± SD or n (%)	HP, mean ± SD or n (%)	P-value
Number of polyps excised	215	215
Size, mm	4.95 ± 1.60	4.94 ± 1.58	0.952a
Morphology			0.847b
Sessile	111 (51.6)	113 (52.6)
Flat	104 (48.4)	102 (47.4)
Location			0.736b
Cecum	13 (6.0)	15 (7.0)
Ascending colon	54 (25.1)	51 (23.7)
Transverse colon	71 (33.0)	48 (22.3)
Descending colon	27 (12.6)	26 (12.1)
Sigmoid colon	41 (19.1)	55 (25.6)
Rectum	9 (4.2)	20 (9.3)
Polypectomy device			0.688c
Snare	213 (99.1)	213 (99.1)
Biopsy forceps	2 (0.9)	2 (0.9)
Pathologic diagnosis1	210 lesions	212 lesions	0.117b
Low-grade adenoma	186 (88.6)	168 (79.2)
Advanced neoplasia2	7 (3.3)	14 (6.6)
Hyperplastic polyp and SSL	14 (6.7)	28 (13.2)
Others	3 (1.4)	2 (0.9)
Failure of tissue retrieval	5 (2.3)	3 (1.4)	0.362c

¹Indicates polyps that were retrieved successfully and evaluated pathologically.

²Defined as high-grade dysplasia or the lesions including villous or tubulovillous adenoma component.

^aStudent's t-test.

^bChi-Square test.

^cFisher's Exact test.

CP: Cold polypectomy; HP: Hot polypectomy; SSL: Sessile serrated lesion.

Table 4 Treatment outcomes and complications

	CP, n (%)	HP, n (%)	P value
	n = 215	n = 215
Macroscopic en bloc resection	213 (99.1)	211 (98.1)	0.343a
Tissue retrieval successfully	210 (97.7)	212 (98.6)	0.362a
Snare polypectomy	208/213 (97.7)	210/213 (98.6)
Biopsy forceps polypectomy	2/2 (100)	2/2 (100)
Lesions diagnosed with low-grade adenoma or advanced lesion and evaluated for histological margin	n = 183	n = 181
Histological complete resection	151 (82.5)	152 (84.0)	0.708b
Complications (%)
Acute bleeding1	6 (2.8)	3 (1.4)	0.252a
Delayed bleeding2	0 (0)	0 (0)	-
Perforation	0 (0)	0 (0)	-

¹Indicates bleeding continued for 30 seconds immediately after polypectomy.

²Indicates bleeding requiring endoscopic hemostasis within two weeks after polypectomy.

^aFisher’s Exact test.

^bChi-Square test.

CP: cold polypectomy; HP: hot polypectomy.

Table 5 Results of follow-up colonoscopy after polypectomy

	CP, mean ± SD or n (%)	HP, mean ± SD or n (%)	P value
Resected polyps	215	215
Follow-up period, mo	17.5 ± 7.1	15.7 ± 6.0	0.005a
Range	6-39	6-35
Local recurrence	2 (0.93)	2 (0.93)	0.688b

^aStudent's t-test.

^bFisher's Exact test.

CP: Cold polypectomy; HP: Hot polypectomy.