Over-feeding the gut microbiome: A scoping review on health implications and therapeutic perspectives

Table 1 Registered clinical trials on ClinicalTrials.gov (as accessed on April 2021) focused on fecal microbiota transplantation for the replacement of obesogenic microbial communities. Search terms included “gut microbiota”, “obesity” and “fecal microbiota transplantation”

Rank	Title	Status	Results	Condition	Intervention	Location	URL
1	Fecal Microbiota Transplantation for the Treatment of Obesity	Completed	Available	Obesity	FMT vs placebo	United States	https://ClinicalTrials.gov/show/NCT02741518
2	Faecal Microbiota Transplantation in Obesity	Recruiting	Not available	Obesity	FMT vs placebo	Finland	https://ClinicalTrials.gov/show/NCT03391817
3	Randomized Controlled Trial of Fecal Microbiota Transplantation in Severe Obesity	Enrolling by invitation	Not available	Obesity	FMT vs placebo	Norway	https://ClinicalTrials.gov/show/NCT03273855
4	Fecal Microbiota Transplant (FMT) to Induce Weight Loss in Obese Subjects	Active, not recruiting	Not available	Obesity	FMT and mucosal microbiota assessment	China	https://ClinicalTrials.gov/show/NCT03789461
5	FMT and Fiber in Patients With Metabolic Syndrome	Completed	Not available	Obesity, Metabolic Syndrome	FMT and dietary supplement with fiber (cellulose) vs placebo	Canada	https://ClinicalTrials.gov/show/NCT03727321
6	Assessment of the Health Improvement of Obese Patients After Fecal Microbiota Transplantation (FMT)	Completed	Not available	Obesity, Type 1 and 2 Diabetes	FMT	Russian Federation	https://ClinicalTrials.gov/show/NCT04579263
7	Fecal Microbiota Transplantation for Diabetes Mellitus Type II in Obese Patients	Unknown status	Not available	T2DM, Obesity	FMT and dietary intervention (high-fat low-fiber diet, sham diet or low-fat high-fiber diet)	Israel	https://ClinicalTrials.gov/show/NCT02346669
8	Fecal Microbial Transplantation and Fiber Supplementation in Participants With Obesity and Metabolic Syndrome	Active, not recruiting	Not available	Obesity, Metabolic Syndrome	FMT and dietary supplement with fiber (cellulose) or FMT only vs placebo	Canada	https://ClinicalTrials.gov/show/NCT03477916
9	Randomised Placebo-controlled Study of FMT to Impact Body Weight and Glycemic Control in Obese Subjects With T2DM	Active, not recruiting	Not available	T2DM, Obesity	FMT and lifestyle modification program or FMT only vs placebo	China	https://ClinicalTrials.gov/show/NCT03127696
10	Fecal Microbiota Transplant for Improvement of Metabolism	Completed	Available	Obesity	FMT vs placebo	United States	https://ClinicalTrials.gov/show/NCT02530385
11	The Role of Microbiome in Recurrent Obesity	Not yet recruiting	Not available	Obesity	FMT vs placebo	Israel	https://ClinicalTrials.gov/show/NCT04697550
12	Effects of Fecal Microbiota Transplantation on Weight in Obese Patients With Non-alcoholic Fatty Liver Disease	Recruiting	Not available	NAFLD	FMT, dietary intervention and physical activity vs placebo	India	https://ClinicalTrials.gov/show/NCT04594954
13	Proposal to Examine the Effect of Fecal Transplantation on Obesity	Unknown status	Not available	Obesity	FMT vs placebo	Israel	https://ClinicalTrials.gov/show/NCT02336789
14	Safety and Efficacy of Fecal Microbiota Transplantation	Recruiting	Not available	IBD, IBS, Obesity, Metabolic Syndrome, Infections, Others	FMT	China	https://ClinicalTrials.gov/show/NCT04014413
15	Transplantation of Microbes for Treatment of Metabolic Syndrome & NAFLD	Completed	Not available	Type 1 and 2 Diabetes, NAFLD, Obesity	FMT	Canada	https://ClinicalTrials.gov/show/NCT02496390

FMT: Fecal Microbiota transplantation; IBD: Inflammatory bowel disease; IBS: Inflammatory bowel syndrome; NAFLD: Non-alcoholic fatty liver disease; T2DM: Type 2 diabetes mellitus.