Serum hepatitis B core-related antigen as a surrogate marker of hepatitis B e antigen seroconversion in chronic hepatitis B

doi:10.3748/wjg.v27.i40.6927

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Oct 28, 2021 (publication date) through Apr 25, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

World J Gastroenterol. Oct 28, 2021; 27(40): 6927-6938
Published online Oct 28, 2021. doi: 10.3748/wjg.v27.i40.6927

Table 1 Baseline characteristics of the patients

Characteristic	n = 139
Age, yr, median (range)	30.4 (19-62)
Sex (male/female, %)	96/43 (69.1/30.9)
HBV genotype, n (%)
B	28 (20.1)
C	111 (79.9)
ALT, U/mL, mean ± SD	174.07 ± 119.82
Serum HBV DNA, log₁₀ IU/mL, mean ± SD	7.59 ± 1.05
Serum pgRNA, log₁₀ copies/mL, mean ± SD	7.82 ± 1.17
ihHBV cccDNA, copies/cell	26.65 ± 11.03
ihHBV DNA, copies/cell	385.13 ± 86.09
Serum HBsAg, log₁₀ IU/mL, mean ± SD	3.81 ± 0.69
Serum HBeAg, log₁₀ S/CO, mean ± SD	2.49 ± 0.82
HBcrAg, log₁₀ U/mL, mean ± SD	5.32 ± 1.18

ALT: Alanine transaminase; cccDNA: Covalently closed circular DNA; HBcrAg: Hepatitis B core-related antigen. HBeAg: Hepatitis B e antigen; HBsAg: Hepatitis B surface antigen; HBV: Hepatitis B virus; ihHBV: Intrahepatic hepatitis B virus.

Citation: Chi XM, Wang XM, Wang ZF, Wu RH, Gao XZ, Xu HQ, Ding YH, Niu JQ. Serum hepatitis B core-related antigen as a surrogate marker of hepatitis B e antigen seroconversion in chronic hepatitis B. World J Gastroenterol 2021; 27(40): 6927-6938
URL: https://www.wjgnet.com/1007-9327/full/v27/i40/6927.htm
DOI: https://dx.doi.org/10.3748/wjg.v27.i40.6927