Higher doses of ascorbic acid may have the potential to promote nutrient delivery via intestinal paracellular absorption

Table 1 Variation in the cumulative excretion of lactulose in bulked urine samples collected over two time periods (first three hours and the second three hours) during a six hours collection period in 28 healthy female participants

Treatment	Lactulose excretion (% recovery of ingested dose)
	First 3 h	Second 3 h
Aspirin	0.37 ± 0.05a,b	0.46 ± 0.05d
Ascorbic acid	0.47 ± 0.05a,c	0.53 ± 0.04
Combined dosage	0.68 ± 0.09b,c	0.77 ± 0.14d

^aStatistically significant (P < 0.05) differences between treatments during the first 3 h, results expressed as mean ± SEM.

^bStatistically significant (P < 0.05) differences between treatments during the first 3 h, results expressed as mean ± SEM.

^cStatistically significant (P < 0.05) differences between treatments during the first 3 h, results expressed as mean ± SEM.

^dStatistically significant (P < 0.05) differences between treatments during the second 3 h during the lactulose mannitol test, results expressed as mean ± SEM.