Urotensin II levels in patients with inflammatory bowel disease

Table 1 Baseline characteristics of the inflammatory bowel disease group and the control group

Parameter	IBD group (n = 50)	Control group (n = 50)	P value1
Male gender, n (%)	31 (62)	29 (58)	0.838
Age (yr)	44.3 ± 14.8	40.6 ± 12.3	0.181
Body weight (kg)	78.4 ± 14.0	81.1 ± 15.0	0.356
Body height (cm)	176.9 ± 9.8	179.6 ± 7.9	0.130
Body mass index (kg/m2)	23.9 ± 3.7	24.9 ± 3.4	0.136
SBP (mmHg)	119.5 ± 11.2	116.6 ± 9.2	0.156
DBP (mmHg)	77.7 ± 8.3	75.0 ± 8.6	0.112
Smoking, n (%)	12 (24.0)	9 (18.4)	0.660
Disease duration (yr)2	6.0 (3.0-11.0)	-	-
UCEIS (score)	6.0 (5.0-7.0)	-	-
SES-CD (score)	9.2 (6.6-12.0)	-	-
Aminosalycilates	32 (64.0%)	-	-
DMARD	15 (30.0%)	-	-
Monoclonal antibodies	29 (58.0%)	-	-

¹Chi-square test or t-test for independent samples.

²Time period since the initial diagnosis.

DBP: Diastolic blood pressure; DMARD: Disease-modifying antirheumatic drug; SBP: Systolic blood pressure; SES-CD: Simple endoscopic score for Crohn’s disease; UCEIS: Ulcerative colitis index of severity. Data are presented as whole number (percentage), mean ± SD or median (interquartile range).

Table 2 Laboratory parameters of the inflammatory bowel disease group and the control group

Parameter	IBD group (n = 50)	Control group (n = 50)	P value1
Erythrocytes (× 1012/L)	4.7 ± 0.5	5.0 ± 0.4	0.020
Hemoglobin (g/L)	140.4 ± 17.3	148.1 ± 13.7	0.015
Fasting glucose (mmol/L)	5.1 ± 0.9	5.0 ± 0.6	0.653
Urea (mmol/L)	4.7 ± 1.5	5.6 ± 1.6	0.004
Creatinine (μmol/L)	71.4 ± 15.3	75.9 ± 14.7	0.134
Total proteins (g/L)	71.2 ± 6.6	72.1 ± 3.9	0.394
Albumins (g/L)	39.5 ± 5.1	43.7 ± 2.4	< 0.001
hsCRP (mg/L)	3.4 ± 2.6	1.2 ± 1.1	< 0.001
Triglycerides (mmol/L)	1.3 ± 0.9	1.1 ± 0.6	0.311
Total cholesterol (mmol/L)	4.8 ± 1.3	5.2 ± 1.2	0.091
HDL cholesterol (mmol/L)	1.3 ± 0.4	1.4 ± 0.3	0.447
LDL cholesterol (mmol/L)	2.6 (2.1-3.4)	3.2 (2.4-3.9)	0.018
FC (μg/g)	231 (61.5-619.2)	-	-

¹t-test for independent samples or Mann-Whitney U test.

FC: Fecal calprotectin; HDL: High-density lipoprotein; HsCRP: High sensitivity C-reactive protein; LDL: Low-density lipoprotein. Data are presented as mean ± SD and median (interquartile range).

Table 3 Correlation analysis between serum urotensin II levels and different biochemical, anthropometric and clinical parameters in the inflammatory bowel disease group (n = 50)

Parameter	r1	P value
hsCRP (mg/L)	0.491	< 0.001
Total proteins (g/L)	-0.306	0.032
Albumins (g/L)	-0.182	0.210
Triglycerides (mmol/L)	0.057	0.698
Total cholesterol (mmol/L)	-0.114	0.439
HDL (mmol/L)	-0.153	0.298
LDL (mmol/L)	-0.1033	0.487
Urea (mmol/L)	0.013	0.928
Creatinine (μmol/L)	0.133	0.356
Age (yr)	-0.072	0.614
Body mass index (kg/m2)	-0.037	0.800
SBP (mmHg)	0.387	0.005
DBP (mmHg)	0.352	0.012
IBD duration (yr)2	0.0453	0.751
FC (μg/g)	0.0483	0.812
UCEIS (score)	0.4253	0.048
SES-CD (score)	0.4663	0.028

¹Pearson’s correlation coefficient.

²Time period before the initial diagnosis.

³Spearman’s rank correlation coefficient.

DBP: Diastolic blood pressure; FC: Fecal calprotectin; hsCRP: High sensitivity C-reactive protein; SBP: Systolic blood pressure; SES-CD: Simple endoscopic score for Crohn’s disease; UCEIS: Ulcerative colitis index of severity.

Table 4 Multiple linear regression model of independent predictors for serum urotensin II levels

Variable	Β1	SE	t value	P value
Age	0.009	0.015	0.570	0.571
Gender	-0.740	0.405	-1.825	0.075
BMI	-0.106	0.059	-1.793	0.080
SBP	0.040	0.017	2.243	0.030
DBP	0.039	0.025	1.535	0.132
hsCRP	0.262	0.076	3.469	< 0.001

¹Unstandardized coefficient β.

BMI: Body mass index; DBP: Diastolic blood pressure; hsCRP: High sensitivity C-reactive protein; SBP: Systolic blood pressure; SE: Standard error.