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©The Author(s) 2021.
World J Gastroenterol. Sep 21, 2021; 27(35): 5967-5977
Published online Sep 21, 2021. doi: 10.3748/wjg.v27.i35.5967
Published online Sep 21, 2021. doi: 10.3748/wjg.v27.i35.5967
Antigen | Clone | Dilution | Antigen retrieval | Localization |
HMB-45 | HMB-45 | 1:400 | None | Cytoplasm |
Melan-A | A103 | 1:200 | Citrate buffer pressure cook | Cytoplasm |
SMA | 1A4 | 1:20000 | None | Cytoplasm |
Desmin | D33 | 1:500 | None | Cytoplasm |
S100 protein | Polyclonal | 1:4000 | Citrate buffer pressure cook | Cytoplasm/nucleus |
Hepatocyte | OCH1E5 | 1:1000 | Citrate buffer pressure cook | Cytoplasm |
Vimentin | V9 | 1:200 | Citrate buffer pressure cook | Cytoplasm |
CD34 | QBEnd/10 | 1:500 | Citrate buffer pressure cook | Cell membrane |
TFE-3 | MRQ-0663 | 1:500 | ETDA buffer pressure cook | Nucleus |
Ki-67 | MX006 | 1:200 | Citrate buffer pressure cook | Nucleus |
No. | Sex/age (yr) | Tumor location | Tumor size (cm) | First diagnosis | Treatment | Follow-up (mo) and prognosis |
1 | F/40 | Left lobe | 2.5 | Left lobe occupying lesion | Left hepatic tumor simple resection | 91, favorable prognosis |
2 | M/57 | Left lobe | 7.5 | Left lobe occupying lesion | Left hepatic tumor simple resection | 80, favorable prognosis |
3 | F/58 | Left lobe | 8.5 | Left lobe occupying lesion | Left hepatic tumor simple resection | 79, favorable prognosis |
4 | F/48 | Right lobe | 8.0 | Right lobe occupying lesion | Right hepatic tumor simple resection | 69, favorable prognosis |
5 | F/64 | Right lobe | 7.0 | Right lobe occupying lesion | Right hepatic tumor simple resection | 66, favorable prognosis |
6 | M/72 | Right lobe | 8.0 | Right lobe occupying lesion | Right hepatic tumor simple resection | 59, favorable prognosis |
7 | F/26 | Right lobe | 3.0 | Right hepatic hamartoma | Extended hepatic lobe resection | 55, favorable prognosis |
8 | M/47 | Right lobe | 6.5 | Right lobe occupying lesion | mTOR inhibitor-sirolimus | 51, favorable prognosis |
9 | F/47 | Left lobe | 5.5 | Left lobe occupying lesion | Extended hepatic lobe resection | 25, favorable prognosis |
10 | M/72 | Right lobe | 8.0 | Right lobe occupying lesion | Extended right hepatic lobe resection | 57, favorable prognosis |
11 | F/56 | Right lobe | 8.0 | Right lobe occupying lesion | mTOR inhibitor-sirolimus | 32, favorable prognosis |
12 | F/54 | Right lobe | 13.0 | Left lobe occupying lesion | Extended left hepatic lobe resection | 99, favorable prognosis |
13 | F/41 | Caudate lobe | 8.0 | Caudate lobe occupying lesion | Caudate hepatic tumor simple resection | 98, favorable prognosis |
14 | F/46 | Left lobe | 2.0 | Left lobe occupying lesion | Extended left hepatic lobe resection | 99, favorable prognosis |
15 | F/54 | Right lobe | 8.0 | Right hepatic hemangioma | Extended Rright hepatic lobe resection | 84, favorable prognosis |
16 | F/41 | Caudate lobe | 6.0 | Caudate lobe occupying lesion | Extended caudate hepatic lobe resection | 87, hepatic pain often occurs after discharge |
17 | M/45 | Right lobe | 0.5 | Right hepatic hemangioma | Extended hepatic lobe resection | 85, favorable prognosis |
18 | F/66 | Right lobe | 5.5 | Right lobe occupying lesion | Extended hepatic lobe resection | 59, favorable prognosis |
19 | F/43 | Right lobe | 2.8 | Right lobe occupying lesion | Extended hepatic lobe resection | 47, favorable prognosis |
20 | F/41 | Left lobe | 5.0 | Left lobe occupying lesion | Extended hepatic lobe resection | 49, reoperation for liver cancer in 2017 |
21 | M/52 | Left lobe | 7.5 | Left lobe occupying lesion | Left hepatic tumor simple resection | 48, favorable prognosis |
22 | F/48 | Right lobe | 9.5 | Right lobe occupying lesion | Extended right hepatic lobe resection | 71, favorable prognosis |
23 | M/58 | Left lobe | 4.0 | Left lobe occupying lesion | Left hepatic tumor simple resection | 70, favorable prognosis |
24 | M/77 | Left lobe | 4.0 | Left lobe occupying lesion | Extended left hepatic lobe resection | 47, favorable prognosis |
25 | M/62 | Left lobe | 6.5 | Left lobe occupying lesion | Extended left hepatic lobe resection | 36, favorable prognosis |
26 | F/45 | Left lobe | 3.0 | Left lobe occupying lesion | Extended left hepatic lobe resection | 35, favorable prognosis |
Target protein | Positive cases (n)/total | % Positive |
HMB45 | 25/26 | 96.2 |
Melan-A | 23/26 | 88.5 |
SMA | 22/26 | 83.6 |
Desmin | 1/26* | 3.8 |
S100 | 14/26 | 53.8 |
Hepatocyte | 9/26 | 34.6 |
Vimentin | 20/26 | 76.9 |
CD34 | 18/26 | 69.2 |
TFE3 | 0/26 | 0 |
Ki-67 (> 10%) | 1/26 | 3.8 |
- Citation: Zhang S, Yang PP, Huang YC, Chen HC, Chen DL, Yan WT, Yang NN, Li Y, Li N, Feng ZZ. Hepatic perivascular epithelioid cell tumor: Clinicopathological analysis of 26 cases with emphasis on disease management and prognosis. World J Gastroenterol 2021; 27(35): 5967-5977
- URL: https://www.wjgnet.com/1007-9327/full/v27/i35/5967.htm
- DOI: https://dx.doi.org/10.3748/wjg.v27.i35.5967