Screening for nonalcoholic fatty liver disease-when, who and how?

Table 1 Scores for diagnosing steatosis and fibrosis with parameters used

	Routine parameters											Special parameters
Scores for Steatosis	AST	ALT	yGT	Platelets	TG	Bilirubin	BMI	Waist	Age	Sex	Diab.	A2 M	HA	Other
FLI			X		X		X	X
HSI	X	X					X			X	X
Steato-Test		X	X		X	X			X	X	Gluc	X		Apo-A1, Haptoglobin, Cholesterol
NAFLD-LFS	X	X									X			Insulin
VAI					X		X	X
TyG					X						Gluc
Scores for fibrosis
NFS	X	X		X			X		X		X			Albumin
FIB-4	X	X		X					X
APRI	X			X
ELF													X	PIIINP, TIMP-1
Fibrotest		X	X			X						X		Haptoglobin,Apo-A1
Fibrometer (V2G) ((V3G))	X		((X)), for HA	X					X	(X)		X	X	Prothrombin, Urea
NIKEI	X	X				X			X

New fibrometer versions (V2G, V3G) and their respective parameters labeled with brackets: (V2G) and ((V3G)). AST: Aspartate-aminotransferase; ALT: Alanine-aminotransferase; yGT: gamma-glutamyltransferase; TG: triglycerides; BMI: Body mass index; Diab.: Diabetes; A2M: Alpha-2-microglobulin; HA: Hyaluronic acid; Gluc: Glucose; PIIINP: Procollagen-III-peptide; TIMP-1: Tissue inhibitor of metalloproteinases I; Apo-A1: Apo-A1-lipoprotein; FLI: Fatty liver index; HIS: Hepatic steatosis index; NAFLD-LFS: Nonalcoholic fatty liver-liver fat score; VAI: Visceral adiposity index; TyG: Triglyceride and glucose index; NFS: NAFLD fibrosis score; FIB-4: Fibrosis-4; APRI: AST-platelet-ratio index; ELF: Enhanced liver fibrosis; NIKEI: Noninvasive Koeln-Essen-index.