Diabetes and pancreatic cancer: Exploring the two-way traffic

Table 1 Factors that can help in differentiating pancreatic cancer associated new onset diabetes from type 2 diabetes mellitus

Clinical indicators	Biochemical markers
Age > 65 yr	Carbohydrate antigen 19-9
Heavy smoker	Galectin 3
Low body mass index	S100A9
History of chronic pancreatitis or gall stone disease	Insulin like growth factor-1
Recent worsening of hyperglycemia in an elderly patient	Osteoprotegerin
Weight loss associated with diabetes onset	Pancreatic polypeptide
Loss of subcutaneous fat and muscle mass in imaging studies like dual energy X-ray absorptiometry or magnetic resonance imaging	Thrombospondins- 1
	Vanin 1
	Matrix metalloproteinase-9
	MicroRNAs