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©The Author(s) 2021.
World J Gastroenterol. Aug 7, 2021; 27(29): 4890-4899
Published online Aug 7, 2021. doi: 10.3748/wjg.v27.i29.4890
Published online Aug 7, 2021. doi: 10.3748/wjg.v27.i29.4890
Table 1 Characteristics of study participants
Controls | Cases | P value | |
Age at diagnosis | 58.7 ± 11.4 | 56.9 ± 10.2 | 0.44 |
Body mass index | 26.8 ± 3.4 | 23.8 ± 2.4 | 0.001 |
Total cholesterol (mg/dL) | 221 ± 52.5 | 221 ± 45.3 | 0.98 |
LDL cholesterol (mg/dL) | 125 ± 40.2 | 124.8 ± 41.9 | 0.99 |
HDL cholesterol (mg/dL) | 54.1 ± 28.7 | 58.5 ± 10.6 | 0.48 |
Triglycerides (mg/dL) | 157 ± 64.6 | 134 ± 54.8 | 0.16 |
Fold increment of ALKP above ULN | 1.82 ± 1.55 | 2.84 ± 2.06 | 0.013 |
Fold increment of ALT above ULN | 2.27 ± 2.94 | 2.23 ± 1.97 | 0.94 |
Fold increment of AST above ULN | 2.08 ± 3.37 | 2.06 ± 1.6 | 0.97 |
Fold increment of GGT above ULN | 4.43 ± 3.57 | 6.74 ± 6.78 | 0.087 |
Bilirubin (mg/dL) | 0.68 ± 0.42 | 1.5 ± 1.9 | 0.007 |
Albumin (g/L) | 4.09 ± 0.32 | 4.05 ± 0.36 | 0.75 |
International normalized ratio | 0.99 ± 0.09 | 1.0 ± 0.13 | 0.56 |
Ascites, n (%) | 2 (4.8) | 3 (7) | 0.66 |
Pruritus, n (%) | 12 (28.6) | 20 (46.5) | 0.08 |
Degree of fibrosis, n (%)1 | |||
0 | 21 (50) | 18 (41.9) | 0.031 |
1 | 14 (33.3) | 8 (18.6) | |
2 | 1 (2.4) | 11 (25.6) | |
3 | 4 (9.5) | 5 (11.6) | |
4 | 2 (4.8) | 1 (2.3) | |
Pattern of anti-nuclear antibodies, n (%) | |||
Peripheral | 0 (0) | 1 (2.3) | 0.37 |
Homogeneous | 0 (0) | 0 (0) | |
Gross speckled | 0 (0) | 0 (0) | |
Fine speckled | 0 (0) | 2 (4.7) | |
Centromeric | 9 (21.4) | 12 (27.9) | |
Nucleolar | 2 (4.8) | 2 (4.7) | |
Laminar | 0 (0) | 0 (0) | |
Cytoplasmic | 6 (14.3) | 2 (4.7) | |
Medications at diagnosis, n (%) | |||
Ursodeoxycholic acid | 16 (38.1) | 37 (86.0) | < 0.001 |
Vitamin E | 15 (35.7) | 3 (7.0) | 0.001 |
Statins | 6 (14.3) | 2 (4.7) | 0.13 |
Antidiabetics | 5 (11.9) | 1 (2.3) | 0.085 |
Immunosuppressors | 11 (26.2) | 13 (30.2) | 0.68 |
Levothyroxine | 15 (35.7) | 15 (34.9) | 0.94 |
Autoimmune comorbidities, n (%) | |||
Sjögren syndrome | 4 (9.5) | 9 (20.9) | 0.14 |
Limited systemic sclerosis | 2 (4.8) | 4 (9.3) | 0.41 |
Diffuse systemic sclerosis | 4 (9.5) | 2 (4.7) | 0.381 |
Hashimoto´s thyroiditis | 5 (11.9) | 6 (14) | 0.78 |
Graves´ disease | 2 (4.8) | 0 (0) | 0.15 |
Systemic lupus erythematosus | 1 (2.4) | 0 (0) | 0.31 |
Inflammatory bowel disease | 0 (0) | 0 (0) | - |
Rheumatoid arthritis | 1 (2.4) | 4 (9.3) | 0.178 |
Hemolytic autoimmune anemia | 1 (2.4) | 0 (0) | 0.31 |
Autoimmune thrombocytopenic purpura | 1 (2.4) | 0 (0) | 0.31 |
Table 2 Sensitivity, specificity and predictive values of each antibody or antibody combination, for the diagnosis of primary biliary cholangitis
Antibody or antibody combination | Sensitivity | Specificity | PPV | NPV |
AMA (+) | 44.2 | 76.2 | 65.5 | 57.1 |
ANA (+) | 74.4 | 38.1 | 55.2 | 59.3 |
ASMA (+) | 14.0 | 73.8 | 35.3 | 45.6 |
IgG (+) | 26.7 | 80.0 | 66.7 | 42.1 |
IgM (+) | 57.1 | 85.7 | 92.3 | 40.0 |
AMA (+), ANA (+) | 25.6 | 83.3 | 61.1 | 52.2 |
AMA (+), ANA (-) | 18.6 | 92.9 | 72.7 | 52.7 |
AMA (-), ANA (+) | 48.8 | 54.8 | 52.5 | 51.1 |
AMA (+), ASMA (+) | 7.0 | 100 | 100 | 51.2 |
AMA (+), ASMA (-) | 37.2 | 76.2 | 61.5 | 54.2 |
AMA (-), ASMA (+) | 7.0 | 73.8 | 21.4 | 43.7 |
ANA (+), ASMA (+) | 9.3 | 83.3 | 36.4 | 47.3 |
ANA (+) , ASMA (-) | 65.1 | 54.8 | 59.6 | 60.5 |
ANA (-), ASMA (+) | 4.7 | 90.5 | 33.3 | 48.1 |
AMA (+), IgG (+) | 13.3 | 90.0 | 66.7 | 40.9 |
AMA (+), IgG (-) | 46.7 | 70.0 | 70.0 | 46.7 |
AMA (-), IgG (+) | 13.3 | 90.0 | 66.7 | 40.9 |
AMA (+), IgM (+) | 52.4 | 85.7 | 91.7 | 37.5 |
AMA (+), IgM (-) | 4.8 | 71.4 | 33.3 | 20.0 |
AMA (-), IgM (+) | 4.8 | 100 | 100 | 25.9 |
- Citation: Guatibonza-García V, Gaete PV, Pérez-Londoño A, Puerto-Baracaldo DK, Gutiérrez-Romero SA, Mendivil CO, Tapias M. Poor performance of anti-mitochondrial antibodies for the diagnosis of primary biliary cholangitis in female Colombian patients: A single-center study. World J Gastroenterol 2021; 27(29): 4890-4899
- URL: https://www.wjgnet.com/1007-9327/full/v27/i29/4890.htm
- DOI: https://dx.doi.org/10.3748/wjg.v27.i29.4890