Metal-organic framework IRMOFs coated with a temperature-sensitive gel delivering norcantharidin to treat liver cancer

Table 1 Release equations and correlation coefficients of norcantharidin-loaded metal-organic framework IRMOF-3 coated with temperature-sensitive gel

	Model	Equation	R2
DM	Zero-order processes	Q = 1.2786 t + 36.322	0.5383
	First-order processes	In (100-Q) = -0.0268 t + 4.1375	0.667
	Higuchi	Q = 9.6078 t0.5 + 25.29	0.7719
	Weibull	InIn (1/1-Q) = 0.3813 Int - 0.9163	0.9508

Table 2 Effects of norcantharidin-loaded metal-organic framework IRMOF-3 coated with temperature-sensitive gel on the cell cycle (n = 3)

Groups (μg/mL)	G0/G1	S	G2/M
Blank group	88.1 ± 2.8	7.2 ± 1.9	4.7 ± 2.1
10	21.9 ± 1.6b	59.4 ± 2.2b	18.7 ± 1.8a
20	16.6 ± 1.2b	54.1 ± 2.4b	29.2 ± 1.9a
40	18.3 ± 2.4b	45.8 ± 3.1b	35.8 ± 2.7a

^aP < 0.05.

^bP < 0.01.