Global research trends in the microbiome related to irritable bowel syndrome: A bibliometric and visualized study

Table 1 Top 10 most productive countries on the microbiome in irritable bowel syndrome research, ranked by the total number of publications in the last two decades (2000-2019)

SCR	Country	Number of documents	%
1st	United States	449	24.0
2nd	United Kingdom	176	9.4
3rd	China	154	8.2
4th	Italy	151	8.1
5th	France	116	6.2
6th	Germany	107	5.7
7th	Canada	103	5.5
8th	Ireland	102	5.4
9th	Australia	72	3.8
10th	Spain	69	3.7

SCR: Standard competition ranking.

Table 2 Top 10 most productive journals on the microbiome in irritable bowel syndrome research, ranked by the total number of publications in the last two decades (2000-2019)

SCR1	Journal	Frequency	%	IF2
1st	World Journal of Gastroenterology	70	3.74	3.665
2nd	Alimentary Pharmacology and Therapeutics	54	2.88	7.515
3rd	Neurogastroenterology and Motility	52	2.78	2.946
4th	Journal of Clinical Gastroenterology	39	2.08	2.973
5th	American Journal of Gastroenterology	34	1.82	10.171
6th	Gastroenterology	33	1.76	17.373
7th	Current Opinion in Gastroenterology	27	1.44	3.225
8th	PLoS One	24	1.28	2.740
9th	Nutrients	21	1.12	4.546
10th	Gut Microbes	20	1.07	7.740

¹Equal journals have the same ranking number, and then a gap is left in the ranking numbers.

²Impact factors based on Journal Citation Reports 2019 from Clarivate Analytics.

SCR: Standard competition ranking; IF: Impact factor.

Table 3 Top 20 most cited articles on the microbiome in irritable bowel syndrome research in the last two decades (2000-2019)

SCR	Ref.	Title	Year	Source title	Cited by
1st	Roberfroid et al[49]	"Prebiotic effects: Metabolic and health benefits"	2010	British Journal of Nutrition	1147
2nd	O'Mahony et al[44]	"Lactobacillus and Bifidobacterium in irritable bowel syndrome: Symptom responses and relationship to cytokine profiles"	2005	Gastroenterology	1042
3rd	Claesson et al[37]	"Composition, variability, and temporal stability of the intestinal microbiota of the elderly"	2011	Proceedings of the National Academy of Sciences of the United States of America	836
4th	Collins et al[38]	"The interplay between the intestinal microbiota and the brain”	2012	Nature Reviews Microbiology	735
5th	Kassinen et al[40]	"The fecal microbiota of irritable bowel syndrome patients differs significantly from that of healthy subjects”	2007	Gastroenterology	684
6th	Pimentel et al[46]	"Rifaximin therapy for patients with irritable bowel syndrome without constipation"	2011	New England Journal of Medicine	659
7th	Rinttilä et al[48]	"Development of an extensive set of 16S rDNA-targeted primers for quantification of pathogenic and indigenous bacteria in faecal samples by real-time PCR"	2004	Journal of Applied Microbiology	658
8th	O'Mahony et al[45]	"Early life stress alters behavior, immunity, and microbiota in rats: implications for irritable bowel syndrome and psychiatric illnesses "	2009	Biological Psychiatry	634
9th	Rolfe[50]	“The role of probiotic cultures in the control of gastrointestinal health”	2000	Journal of Nutrition	584
10h	Carabotti et al[36]	“The gut-brain axis: Interactions between enteric microbiota, central and enteric nervous systems"	2015	Annals of Gastroenterology	580
11th	De Vrese and Schrezenmeir[39]	"Probiotics, prebiotics, and synbiotics"	2008	Advances in Biochemical Engineering/Biotechnology	575
12th	Rajilić-Stojanović et al[47]	"Global and deep molecular analysis of microbiota signatures in fecal samples from patients with irritable bowel syndrome"	2011	Gastroenterology	545
13th	Whorwell et al[55]	"Efficacy of an encapsulated probiotic Bifidobacterium infantis 35624 in women with irritable bowel syndrome"	2006	American Journal of Gastroenterology	541
13th	Swidsinski et al[54]	"Spatial organization and composition of the mucosal flora in patients with inflammatory bowel disease"	2005	Journal of Clinical Microbiology	541
15th	Malinen et al[41]	"Analysis of the fecal microbiota of irritable bowel syndrome patients and healthy controls with real-time PCR"	2005	American Journal of Gastroenterology	523
16th	Mayer et al[42]	"Gut/brain axis and the microbiota"	2015	Journal of Clinical Investigation	519
17th	Simrén et al[52]	"Intestinal microbiota in functional bowel disorders: A Rome foundation report"	2013	Gut	510
18th	Spiller and Garsed[53]	"Postinfectious irritable bowel syndrome "	2009	Gastroenterology	508
19th	Rousseaux et al[51]	"Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors"	2007	Nature Medicine	500
20th	Nobaek et al[43]	"Alteration of intestinal microflora is associated with reduction in abdominal bloating and pain in patients with irritable bowel syndrome"	2000	American Journal of Gastroenterology	498

Table 4 Top 10 most productive institutions on the microbiome in irritable bowel syndrome research, ranked by the total number of publications in the last two decades (2000-2019)

SCR1	Institute	Country	n	%
1st	University College Cork	Ireland	87	4.65
2nd	APC Microbiome Ireland	Ireland	84	4.49
3rd	McMaster University	Canada	45	2.40
4th	Alma Mater Studiorum Università di Bologna	Italy	38	2.03
5th	Helsingin Yliopisto	Finland	36	1.92
5th	Mayo Clinic	United States	36	1.92
7th	Inserm (Institut national de la santé et de la recherche médicale)	France	30	1.60
8th	Baylor College of Medicine	United States	27	1.44
9th	Göteborgs Universitet	Sweden	27	1.44
10th	The University of North Carolina at Chapel Hill	United States	27	1.44

¹Equal institutes have the same ranking number, and then a gap is left in the ranking numbers.

SCR: Standard competition ranking.