Copyright ©The Author(s) 2021.
World J Gastroenterol. Apr 7, 2021; 27(13): 1341-1353
Published online Apr 7, 2021. doi: 10.3748/wjg.v27.i13.1341
Table 1 Top 10 most productive countries on the microbiome in irritable bowel syndrome research, ranked by the total number of publications in the last two decades (2000-2019)
Number of documents
1stUnited States44924.0
2ndUnited Kingdom1769.4
Table 2 Top 10 most productive journals on the microbiome in irritable bowel syndrome research, ranked by the total number of publications in the last two decades (2000-2019)
1stWorld Journal of Gastroenterology703.743.665
2ndAlimentary Pharmacology and Therapeutics542.887.515
3rdNeurogastroenterology and Motility522.782.946
4thJournal of Clinical Gastroenterology392.082.973
5thAmerican Journal of Gastroenterology341.8210.171
7thCurrent Opinion in Gastroenterology271.443.225
8thPLoS One241.282.740
10thGut Microbes201.077.740
Table 3 Top 20 most cited articles on the microbiome in irritable bowel syndrome research in the last two decades (2000-2019)
Source title
Cited by
1stRoberfroid et al[49]"Prebiotic effects: Metabolic and health benefits"2010British Journal of Nutrition1147
2ndO'Mahony et al[44]"Lactobacillus and Bifidobacterium in irritable bowel syndrome: Symptom responses and relationship to cytokine profiles"2005Gastroenterology1042
3rdClaesson et al[37]"Composition, variability, and temporal stability of the intestinal microbiota of the elderly"2011Proceedings of the National Academy of Sciences of the United States of America836
4thCollins et al[38]"The interplay between the intestinal microbiota and the brain”2012Nature Reviews Microbiology735
5thKassinen et al[40]"The fecal microbiota of irritable bowel syndrome patients differs significantly from that of healthy subjects”2007Gastroenterology684
6thPimentel et al[46]"Rifaximin therapy for patients with irritable bowel syndrome without constipation"2011New England Journal of Medicine659
7thRinttilä et al[48]"Development of an extensive set of 16S rDNA-targeted primers for quantification of pathogenic and indigenous bacteria in faecal samples by real-time PCR"2004Journal of Applied Microbiology658
8thO'Mahony et al[45]"Early life stress alters behavior, immunity, and microbiota in rats: implications for irritable bowel syndrome and psychiatric illnesses "2009Biological Psychiatry634
9thRolfe[50]“The role of probiotic cultures in the control of gastrointestinal health”2000Journal of Nutrition584
10hCarabotti et al[36]“The gut-brain axis: Interactions between enteric microbiota, central and enteric nervous systems"2015Annals of Gastroenterology580
11th De Vrese and Schrezenmeir[39]"Probiotics, prebiotics, and synbiotics"2008Advances in Biochemical Engineering/Biotechnology575
12th Rajilić-Stojanović et al[47]"Global and deep molecular analysis of microbiota signatures in fecal samples from patients with irritable bowel syndrome"2011Gastroenterology545
13th Whorwell et al[55]"Efficacy of an encapsulated probiotic Bifidobacterium infantis 35624 in women with irritable bowel syndrome"2006American Journal of Gastroenterology541
13th Swidsinski et al[54]"Spatial organization and composition of the mucosal flora in patients with inflammatory bowel disease"2005Journal of Clinical Microbiology541
15th Malinen et al[41]"Analysis of the fecal microbiota of irritable bowel syndrome patients and healthy controls with real-time PCR"2005American Journal of Gastroenterology523
16th Mayer et al[42]"Gut/brain axis and the microbiota"2015Journal of Clinical Investigation519
17th Simrén et al[52]"Intestinal microbiota in functional bowel disorders: A Rome foundation report"2013Gut510
18th Spiller and Garsed[53]"Postinfectious irritable bowel syndrome "2009Gastroenterology508
19th Rousseaux et al[51]"Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors"2007Nature Medicine500
20th Nobaek et al[43]"Alteration of intestinal microflora is associated with reduction in abdominal bloating and pain in patients with irritable bowel syndrome"2000American Journal of Gastroenterology498
Table 4 Top 10 most productive institutions on the microbiome in irritable bowel syndrome research, ranked by the total number of publications in the last two decades (2000-2019)
1stUniversity College CorkIreland874.65
2ndAPC Microbiome IrelandIreland844.49
3rdMcMaster UniversityCanada452.40
4thAlma Mater Studiorum Università di BolognaItaly382.03
5thHelsingin YliopistoFinland 361.92
5thMayo ClinicUnited States361.92
7thInserm (Institut national de la santé et de la recherche médicale)France 301.60
8thBaylor College of MedicineUnited States271.44
9thGöteborgs UniversitetSweden271.44
10th The University of North Carolina at Chapel HillUnited States271.44