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©The Author(s) 2021.
World J Gastroenterol. Mar 21, 2021; 27(11): 1055-1063
Published online Mar 21, 2021. doi: 10.3748/wjg.v27.i11.1055
Published online Mar 21, 2021. doi: 10.3748/wjg.v27.i11.1055
Table 1 Comparison of clinical data between the Parkinson's disease with constipation and functional constipation groups
FC | PDC | P value | |
Male | 7 (35.0%) | 12 (60.0%) | 0.205 |
Female | 13 (65.0%) | 8 (40.0%) | |
Age, years | 70.80 (6.24) | 72.32 (4.80) | 0.402 |
BMI | 23.32 (2.47) | 22.25 (4.32) | 0.343 |
Decreased defecation frequency | 10 (50.0%) | 16 (80.0%) | 0.097 |
Dry stools | 9 (45.0%) | 6 (30.0%) | 0.514 |
Defecatory difficulties | 13 (65.0%) | 20 (100.0%) | 0.013 |
Manual assisted defecation | 7 (35.0%) | 12 (60.0%) | 0.205 |
Constipation duration, years | 10.00 (5.00, 20.00) | 5.00 (2.75, 6.50) | 0.051 |
Table 2 Comparison of high-resolution anorectal manometry results between the Parkinson's disease with constipation and functional constipation groups
FC | PDC | P value | |
Rectal resting pressure (mmHg) | 82.36 (20.18) | 63.98 (30.94) | 0.032 |
Anal sphincter resting pressure (mmHg) | 89.55 (16.25) | 66.50 (19.35) | < 0.001 |
Rectal maximum squeeze pressure (mmHg) | 189.50 (159.95,250.68) | 188.95 (139.60,234.00) | 0.516 |
Anal canal maximum squeeze pressure (mmHg) | 222.16 (86.26) | 195.25 (63.62) | 0.269 |
Intrarectal pressure (mmHg) | 43.08 (20.74) | 21.73 (14.61) | 0.001 |
Anal relaxation rate (%) | 23.00 (16.00, 42.58) | 0.16 (-0.07, 0.22) | < 0.001 |
Residual anal pressure (mmHg) | 75.83 (33.55) | 69.70 (30.92) | 0.551 |
Rectoanal pressure difference (mmHg) | -36.77 (36.56) | -47.98 (27.38) | 0.279 |
Paradoxical contraction | 1 (5.0%) | 8 (40.0%) | 0.023 |
Table 3 Comparison of the composition type of defecatory disorders between the Parkinson's disease with constipation and functional constipation groups, n (%)
FC | PDC | P value | |
Defecatory impetus deficiency | 8 (40.0) | 10 (50.0) | 0.037 |
Pelvic floor muscle dyssynergia | 4 (20.0) | 7 (35.0) | |
Inadequate defecatory propulsion combined with pelvic floor muscle dyssynergia | 0 (0.0) | 2 (10.0) | |
Normal | 8 (40.0) | 1 (5.0) |
Table 4 Comparison of colonic transit time between the two groups
FC | PDC | P value | |
RCTT (h) | 10.50 (3.12) | 8.40 (3.28) | 0.045 |
LCTT (h) | 19.50 (6.07) | 20.15 (5.07) | 0.715 |
RSCTT (h) | 24.45 (4.56) | 27.60 (3.68) | 0.021 |
TCTT (h) | 55.10 (7.46) | 56.00 (8.31) | 0.721 |
Table 5 Comparison of constipation classification between the Parkinson's disease with constipation and functional constipation groups, n (%)
FC | PDC | P value | |
Slow transit constipation | 7 (35.0) | 1 (5.0) | 0.067 |
Defecatory disorder | 2 (10.0) | 4 (20.0) | |
Mixed constipation | 10 (50.0) | 15 (75.0) | |
Normal transit constipation | 1 (5.0) | 0 (0.0) |
- Citation: Zhang M, Yang S, Li XC, Zhu HM, Peng D, Li BY, Jia TX, Tian C. Study on the characteristics of intestinal motility of constipation in patients with Parkinson's disease. World J Gastroenterol 2021; 27(11): 1055-1063
- URL: https://www.wjgnet.com/1007-9327/full/v27/i11/1055.htm
- DOI: https://dx.doi.org/10.3748/wjg.v27.i11.1055