Study on the characteristics of intestinal motility of constipation in patients with Parkinson's disease

Table 1 Comparison of clinical data between the Parkinson's disease with constipation and functional constipation groups

	FC	PDC	P value
Male	7 (35.0%)	12 (60.0%)	0.205
Female	13 (65.0%)	8 (40.0%)
Age, years	70.80 (6.24)	72.32 (4.80)	0.402
BMI	23.32 (2.47)	22.25 (4.32)	0.343
Decreased defecation frequency	10 (50.0%)	16 (80.0%)	0.097
Dry stools	9 (45.0%)	6 (30.0%)	0.514
Defecatory difficulties	13 (65.0%)	20 (100.0%)	0.013
Manual assisted defecation	7 (35.0%)	12 (60.0%)	0.205
Constipation duration, years	10.00 (5.00, 20.00)	5.00 (2.75, 6.50)	0.051

PDC: Parkinson's disease with constipation; FC: Functional constipation; BMI: Body mass index.

Table 2 Comparison of high-resolution anorectal manometry results between the Parkinson's disease with constipation and functional constipation groups

	FC	PDC	P value
Rectal resting pressure (mmHg)	82.36 (20.18)	63.98 (30.94)	0.032
Anal sphincter resting pressure (mmHg)	89.55 (16.25)	66.50 (19.35)	< 0.001
Rectal maximum squeeze pressure (mmHg)	189.50 (159.95,250.68)	188.95 (139.60,234.00)	0.516
Anal canal maximum squeeze pressure (mmHg)	222.16 (86.26)	195.25 (63.62)	0.269
Intrarectal pressure (mmHg)	43.08 (20.74)	21.73 (14.61)	0.001
Anal relaxation rate (%)	23.00 (16.00, 42.58)	0.16 (-0.07, 0.22)	< 0.001
Residual anal pressure (mmHg)	75.83 (33.55)	69.70 (30.92)	0.551
Rectoanal pressure difference (mmHg)	-36.77 (36.56)	-47.98 (27.38)	0.279
Paradoxical contraction	1 (5.0%)	8 (40.0%)	0.023

PDC: Parkinson's disease with constipation; FC: Functional constipation.

Table 3 Comparison of the composition type of defecatory disorders between the Parkinson's disease with constipation and functional constipation groups, n (%)

	FC	PDC	P value
Defecatory impetus deficiency	8 (40.0)	10 (50.0)	0.037
Pelvic floor muscle dyssynergia	4 (20.0)	7 (35.0)
Inadequate defecatory propulsion combined with pelvic floor muscle dyssynergia	0 (0.0)	2 (10.0)
Normal	8 (40.0)	1 (5.0)

PDC: Parkinson's disease with constipation; FC: Functional constipation.

Table 4 Comparison of colonic transit time between the two groups

	FC	PDC	P value
RCTT (h)	10.50 (3.12)	8.40 (3.28)	0.045
LCTT (h)	19.50 (6.07)	20.15 (5.07)	0.715
RSCTT (h)	24.45 (4.56)	27.60 (3.68)	0.021
TCTT (h)	55.10 (7.46)	56.00 (8.31)	0.721

Normal reference values: right colon transit time ≤ 17.4 h; left colon transit time ≤ 16.8 h; rectosigmoid transit time ≤ 22.9 h; total colonic transit time ≤ 39 h for men and ≤ 50 h for women. PDC: Parkinson's disease with constipation; FC: Functional constipation; RCTT: Right colonic transit time; LCTT: Left colonic transit time; RSCTT: Rectosigmoid colonic transit time; TCTT: Total colonic transit time.

Table 5 Comparison of constipation classification between the Parkinson's disease with constipation and functional constipation groups, n (%)

	FC	PDC	P value
Slow transit constipation	7 (35.0)	1 (5.0)	0.067
Defecatory disorder	2 (10.0)	4 (20.0)
Mixed constipation	10 (50.0)	15 (75.0)
Normal transit constipation	1 (5.0)	0 (0.0)

PDC: Parkinson's disease with constipation; FC: Functional constipation.