Systematic Reviews
Copyright ©The Author(s) 2020.
World J Gastroenterol. Oct 28, 2020; 26(40): 6270-6278
Published online Oct 28, 2020. doi: 10.3748/wjg.v26.i40.6270
Table 1 Characteristics of included studies
Study design
Study population
AP, n (%)
Aloysius et al[29], United StatesCase reportOne AP patient with COVID-191 (100)36-year-old obese female presenting with AP. No sign of biliary pathology, denies alcoholism, TG unremarkable
Anand et al[44], United KingdomCase reportOne AP patient with COVID-191 (100)A 59-year-old cholecystectomized woman with minimal alcohol consumption, readmitted with abdominal symptoms five days after discharge with doxycycline for co-infection. CT showed signs of AP on a formerly atrophic pancreas
Gou et al[21], ChinaCase reportFour “pancreatic disease” patients with COVID-19 pneumonia1 (25)One female with AP (51), biliary etiology confirmed, showed initial COVID-19 symptoms 18 d after admission
Hadi et al[45], DenmarkCase reportThree family members with COVID-192 (67)Idiopathic AP in mother (68) and daughter (47), both requiring intensive care and ventilation
Hossain et al[23], United StatesRetrospective cohort119 COVID-19 patients presenting at ER with non-respiratory symptoms3/32 (9.4)Out of the 101 instances where abdominal/pelvic CT was obtained, 32 had acute/significant findings, including three cases of pancreatitis. No more information available on these patients
Li et al[22], ChinaRetrospective cohort25 death cases with COVID-191 (4)A 56-year-old male patient had AP as an “underlying disease”–it is not clear whether this is from his medical history or was present concomitantly
Meireles et al[46], PortugalCase reportOne AP patient with COVID-191 (100)36-year-old female, AP symptoms started on day 11 of disease, US and CT showed no signs of biliary pathology/ischemia. No information on alcohol consumption. Negatively screened for multiple viruses
Morrison et al[20], United StatesCase reportTwo cases of acute hypertriglyceridemia in COVID-19 patients1 (50)Acute hypertriglyceridemia-induced AP after treatment with tocilizumab, ritonavir, lopinavir, ribavirin, hydroxychloroquine, and propofol
Table 2 Diagnostic and etiological workup and quality assessment of the studies
Ref.Diagnostic workup
COVID-19 (PCR)Etiological workup
Quality of case reports
Abdominal pain
Enzyme elevation (3 x)
HTG (> 11.5 mmol/L)
Viral (except nCoV)
JBI Overall rating ( /8)
Written according to CARE
Aloysius et al[29], United States++-+?---????-3No
Anand et al[44], United Kingdom+?++?-?+????-0No
Hadi et al[45], Denmark?+++?--?-+???4No
Meireles et al[46], Portugal++-+?--------1No
Morrison et al[20], United States?+?+??++?+???1No