Trends and risk factors of elderly-onset Crohn’s disease: A nationwide cohort study

Table 1 Characteristics of patients with Crohn’s disease and the healthy population (control) in the middle-age-onset group

	Non-CD control	CD patients	P value
	(n = 9499756)	(n = 977)
Age, yr	50.01 ± 6.73	50.00 ± 6.70	0.961
Sex			< 0.001
Male	4660907 (49.06)	570 (58.34)
Smoking			< 0.001
Non-smoker	5945314 (62.58)	532 (54.45)
Ex-smoker	1455702 (15.32)	204 (20.88)
Current smoker	2098740 (22.09)	241 (24.67)
Drinking			0.355
0	5258307 (55.35)	559 (57.22)
0-30 g	3599536 (37.89)	361 (36.95)
> 30 g	641913 (6.76)	57 (55.83)
Regular exercise2	4974091 (52.36)	483 (49.44)	0.067
Lowest income 20%1	2446619 (25.75)	234 (23.95)	0.197
Diabetes mellitus	898517 (9.46)	90 (9.21)	0.792
Hypertension	2556964 (26.92)	258 (26.41)	0.720
Dyslipidemia	2041629 (21.49)	167 (17.09)	0.001
Chronic kidney disease	430175 (4.53)	59 (6.04)	0.023
Body mass index	23.97 ± 3.02	23.40 ± 3.00	< 0.001
Waist circumference	80.54 ± 8.65	80.78 ± 8.81	0.400
Systolic blood pressure	122.43 ± 14.88	120.9 ± 13.88	0.001
Diastolic blood pressure	76.7 ± 10.19	75.79 ± 9.62	0.006
Fasting glucose1	98.99 ± 24.11	96.83 ± 21.55	0.005

Values are presented as number (%) or mean ± SD.

¹Those with income in the bottom 20% of the national population.

²Performing high-intensity exercise for > 3 d/wk for at least 30 min or moderate-intensity exercise for > 5 d/wk for at least 20 min. CD: Crohn’s disease.

Table 2 Characteristics of patients with Crohn’s disease and the healthy population (control) in the elderly-onset group

	Non-CD control	CD patients	P value
	(n = 4559688)	(n = 400)
Age, yr	70.50 ± 5.33	69.92 ± 4.40	0.029
Sex
Male	2031794 (44.56)	175 (43.75)	0.745
Smoking			0.033
Non-smoker	3288608 (72.12)	278 (69.50)
Ex-smoker	716415 (15.71)	81 (20.25)
Current smoker	554665 (12.16)	41 (10.25)
Drinking			0.005
0	3444333 (75.54)	327 (81.75)
0-30 g	951250 (20.86)	57 (14.25)
> 30 g	164105 (3.60)	16 (4.00)
Regular exercise2	1804398 (39.57)	158 (39.5)	0.976
Lowest income 20%1	1163622 (25.52)	111 (27.75)	0.306
Diabetes mellitus	976144 (21.41)	84 (21.00)	0.8423
Hypertension	2678260 (58.74)	245 (61.25)	0.308
Dyslipidemia	1578582 (34.62)	144 (36)	0.562
Chronic kidney disease	724332 (15.89)	59 (14.75)	0.534
Body mass index	23.99 ± 3.17	23.72 ± 3.24	0.084
Waist circumference	83.14 ± 8.48	82.9.6 ± 8.84	0.658
Systolic blood pressure	129.63 ± 15.92	126.69 ± 16.05	0.940
Diastolic blood pressure	77.90 ± 9.92	77.5 ± 9.87	0.421
Fasting glucose1	104.19 ± 26.88	103.04 ± 28.95	0.394

Values are presented as number (%) or mean ± SD.

¹Those with income in the bottom 20% of the national population.

²Performing high-intensity exercise for > 3 d/wk for at least 30 min or moderate-intensity exercise for > 5 d/wk for at least 20 min. CD: Crohn’s disease.