Differential regulation of JAK/STAT-signaling in patients with ulcerative colitis and Crohn’s disease

Table 1 Genetic association between JAK/STAT-signaling and the development of inflammatory bowel disease

	Ulcerative colitis	Crohn’s disease
JAK1	No association found to date	No association found to date
JAK2	Yang et al[140], 2011	Yang et al[140], 2011
	Barrett et al[136], 2008	Barrett et al[136], 2008
	Wellcome trust case control	Wellcome trust case control
	Consortium[138], 2007	Consortium[138], 2007
	Anderson et al[141], 2009	Anderson et al[141], 2009
	Zhang et al[142], 2014	Zhang et al[142], 2014
	Hedl et al[143], 2016	Hedl et al[143], 2016: N/A
	Cleynen et al[144], 2013: N/A	Cleynen et al[144], 2013
	Ferguson et al[145], 2010: N/A	Ferguson et al[145], 2010
	Prager et al[146], 2014: No association	Prager et al[146], 2014
JAK3	No association found to date	No association found to date
TYK2	Can et al[147], 2015	Can et al[147], 2015
	Lian et al[148], 2013	Lian et al[148], 2013: No association
	Sato et al[149], 2009: No association	Sato et al[149], 2009
STAT1	No association found to date	No association found to date
STAT2	No association found to date	No association found to date
STAT3	Barrett et al[136], 2008	Barrett et al[136], 2008
	Wellcome Trust Case Control	Wellcome Trust Case Control
	Consortium[138], 2007	Consortium[138], 2007
	Anderson et al[150], 2011	Anderson et al[150], 2011
	Willson et al[151], 2012: N/A	Willson et al[151], 2012 (pediatric patients)
	Zhang et al[142], 2014	Zhang et al[142], 2014
	Prager et al[146], 2014: No association	Prager et al[146], 2014
STAT4	Glas et al[152], 2010: No association	Glas et al[152], 2010
	Diaz-Gallo et al[153], 2010	Diaz-Gallo et al[153], 2010: No association
	Liu et al[139], 2015	Liu et al[139], 2015: No association
STAT5	Huang et al[154], 2015 (STAT5A/STAT3 haplotypes): No association	Huang et al[154], 2015 (STAT5A/STAT3 haplotypes)
STAT6	Klein et al[155], 2015: No association	Klein et al[155], 2015
	Xia et al[156], 2003: No association	Xia et al[156], 2003: No association
	Chua et al[157], 2016: No association	Chua et al[157], 2016: No association
	de Jong et al[158], 2003: No association	de Jong et al[158], 2003: No association

JAK: Janus kinase; N/A: Not investigated in this cohort; STAT: Signal transducer and activator of transcription.