Comparison of operative link for gastritis assessment, operative link on gastric intestinal metaplasia assessment, and TAIM stagings among men with atrophic gastritis

Table 1 Patient characteristics

Characteristics	Data	Range
Number of participants	1147
Gender (Male/female)	100%/0%
Age1 (yr, median)	64.1	54.0-77.5
Median follow-up time (yr)	13.7	16 (d)-27.3
Number of smoked cigarettes per day1 (Median)	20.0	5.0-50.0
Smoking years1 (Median)	38.0	3.0-57.0
Helicobacter pylori1 (Positive histology)	28.2%

¹At the beginning of the study.

Table 2 TAIM staging system

Severity	Location
	Antrum	Corpus	Whole stomach
No atrophy/IM	Low (0)	Low (0)	Low (0)
Mild atrophy/IM	Low (I)	Low (I)	Low (I)
Moderate atrophy/IM	Low (II)	Low (II)	High (II-III)
Marked atrophy/IM	High (III)	High (II)	High (IV)

No atrophy/intestinal metaplasia includes biopsies with healthy mucosa or inflammation without atrophy. Operative link for gastritis assessment/operative link on gastric intestinal metaplasia assessment stage in parenthesis. IM: Intestinal metaplasia.

Table 3 Operative link for gastritis assessment staging

	Corpus
	0 (No atrophy)	1 (Mild)	2 (Moderate)	3 (Marked)
Antrum 0 (No atrophy)	0 (1/103)	I (3/116)	II (7/395)	II (8/259)
Antrum 1 (Mild)	I (0/5)	I (0/15)	II (3/60)	III (0/26)
Antrum 2 (Moderate)	II (0/4)	II (0/6)	III (1/32)	IV (1/26)
Antrum 3 (Marked)	III (0/0)	III (0/7)	IV (2/41)	IV (2/42)

Distribution of diagnosed gastric cancer cases and amount of participants in parenthesis.

Table 4 Operative link for gastritis assessment, operative link on gastric intestinal metaplasia assessment, and TAIM stagings and gastric cancer risk

	n	Gastric cancers	H. pylori pos (%)	HR	95%CI	P value
OLGA stage
0	103	1	25.2	1.00
I	136	3	44.1	2.66	0.28-25.72
II	724	18	24.7	2.84	0.38-21.38	0.10
III	65	1	35.4	1.85	0.11-29.87
IV	109	5	25.7	5.77	0.67-49.77
OLGIM stage
0	205	2	33.7	1.00
I	404	7	28.0	1.82	0.37-8.83
II	316	10	27.8	3.55	0.77-16.36	0.004
III	115	5	26.1	5.91	1.14-30.73
IV	100	4	18.0	5.72	1.03-31.77
TAIM stage
Low	475	6	32.6	1.00
High	662	22	24.3	2.70	1.09-6.69	0.03

HR: Hazard ratio; OLGA: Operative link for gastritis assessment; OLGIM: Operative link on gastric intestinal metaplasia assessment.

Table 5 Operative link on gastric intestinal metaplasia assessment staging

	Corpus
	0 (No IM)	1 (Mild)	2 (Moderate)	3 (Marked)
Antrum 0 (No IM)	0 (2/205)	I (2/239)	II (5/133)	II (2/31)
Antrum 1 (Mild)	I (2/45)	I (3/120)	II (1/88)	III (1/39)
Antrum 2 (Moderate)	II (0/15)	II (2/49)	III (2/45)	IV (1/32)
Antrum 3 (Marked)	III (1/14)	III (1/17)	IV (2/30)	IV (1/38)

Distribution of diagnosed gastric cancer cases and the amount of the participants in parenthesis. IM: Intestinal metaplasia.

Table 6 TAIM staging

Severity	Location
	Antrum	Corpus	Whole stomach
No atrophy/IM	0	0	1/74
Mild atrophy /IM	0/14	1/87	0/35
Moderate atrophy /IM	0/5	4/260	8/235
Marked atrophy /IM	0	5/179	9/248

Distribution of diagnosed gastric cancer cases/the amount of the participants. IM: Intestinal metaplasia.

Table 7 Gastric cancer cases during the follow-up period by operative link for gastritis assessment, operative link on gastric intestinal metaplasia assessment, and TAIM stagings

	Cases/Men	%	Sensitivity (%)	Specificity (%)
OLGA
0-II	22/963	2.28	21.4	84.9
III-IV	6/174	3.45
OLGIM
0-II	19/925	2.05	32.1	81.4
III-IV	9/215	4.19
TAIM
low	6/475	1.26	78.6	42.3
high	22/662	3.32

OLGA: Operative link for gastritis assessment; OLGIM: Operative link on gastric intestinal metaplasia assessment.

Table 8 Standardized incidence rates of general male population compared to low and high-risk patients in operative link for gastritis assessment, operative link on gastric intestinal metaplasia assessment, and TAIM staging systems

	SIR	95%CI	P value
OLGA
General population	1.00
Low (0-II)	2.10	1.32-3.18	0.003
High (III-IV)	3.03	1.11-6.60	0.03
OLGIM
General population	1.00
Low (0-II)	1.86	1.12-2.90	0.02
High (III-IV)	4.00	1.83-7.60	0.001
TAIM
General population	1.00
Low-risk	1.17	0.43-2.54	0.82
High-risk	3.00	1.88-4.55	< 0.001

SIR: Standardized incidence rate; OLGA: Operative link for gastritis assessment; OLGIM: Operative link on gastric intestinal metaplasia assessment.