Basic Study
Copyright ©The Author(s) 2019.
World J Gastroenterol. Oct 14, 2019; 25(38): 5814-5825
Published online Oct 14, 2019. doi: 10.3748/wjg.v25.i38.5814
Table 1 Correlation between Wnt1-inducible signaling pathway protein 1 expression and clinicopathological variables in gastric cancer patients
VariableNumberLow expression (n = 67)High expression (n = 83)P value
Age (yr)
< 606325380.299
≥ 60874245
Gender
Male6930390.789
Female813744
Tumor differentiation
Well/moderate8033470.372
Poor703436
T stage
T1-T28145360.003
T3-T4692247
N stage
N03916230.598
N1-N31115160
TNM stage
I-II10949600.909
III411823
Chemotherapy outcome
CR/PR6738290.019
SD/PD833053
Table 2 Univariate and multivariate analyses of prognostic factors for gastric cancer
VariableUnivariate analysis
Multivariate analysis
HR (95%CI)P valueHR (95%CI)P value
Age (> 60 vs < 60)1.003 (0.618-1.628)0.991
Gender (Female vs Male)0.874 (0.639-1.195)0.400
Differentiation (Poorly vs Well/moderately)1.236 (0.760-2.009)0. 393
TNM stage (III vs I-II)3.714 (2.261-6.102)< 0.0012.676 (1.236-5.793)0.013
T stage (T3-T4 vs T2-T1)1.931 (1.178-3.165)0.009
N stage (N1-N3 vs N0)2.666 (1.599-4.448)< 0.0012.089 (1.169-3.732)0.013
Chemotherapy outcome (SD/PD vs CR/PR)3.254 (1.885-5.616)< 0.001
WISP1 (High vs Low)2.341 (1.385-3.956)0.00192.180 (1.187-4.003)0.012