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©The Author(s) 2019.
World J Gastroenterol. Sep 14, 2019; 25(34): 5152-5161
Published online Sep 14, 2019. doi: 10.3748/wjg.v25.i34.5152
Published online Sep 14, 2019. doi: 10.3748/wjg.v25.i34.5152
Table 1 Demographic characteristics of the participants
Case | Control | X2 | P-value | ||
n = 956 | n = 1012 | ||||
Age (yr) | |||||
≤60 | 569 (59.5) | 637 (62.9) | 2.289 | 0.130 | |
>60 | 387 (40.5) | 375 (37.1) | |||
Gender | |||||
Male | 667 (69.8) | 724 (71.5) | 0.662 | 0.416 | |
Female | 289 (30.2) | 288 (28.5) | |||
H. pylori infection | |||||
Positive | 675 (70.6) | 542 (53.6) | 59.835 | <0.001 | |
Negative | 281 (29.4) | 470 (46.4) | |||
Drinking | |||||
No | 758 (79.3) | 497 (49.1) | 2.787 | 0.095 | |
Yes | 198 (20.7) | 515 (50.9) | |||
Smoking | |||||
No | 560 (58.6) | 517 (51.1) | 1.382 | 0.240 | |
Yes | 396 (41.4) | 495 (48.9) |
Table 2 Single nucleotide polymorphism and genotype distribution between gastric cancer cases and controls
SNP | Genotype | Case | Control | HWE | P-value | OR | 95%CI | P-value | OR1 | 95%CI | P-value |
n = 956 | n = 1012 | ||||||||||
Rs2094258 | CC | 390 (40.8) | 437 (43.2) | 0.318 | 0.853 | 1.00 | |||||
CT | 441 (46.1) | 464 (45.8) | 1.07 | 0.88-1.29 | 0.545 | 1.05 | 0.86-1.31 | 0.626 | |||
TT | 125 (13.1) | 111 (11.0) | 1.26 | 0.94-1.69 | 0.133 | 1.19 | 0.90-1.20 | 0.249 | |||
Dominant | 566 (59.2) | 575 (56.8) | 1.10 | 0.92-1.32 | 0.284 | 1.06 | 0.87-1.37 | 0.388 | |||
Recessive | 831 (86.9) | 901 (89.0) | 1.22 | 0.93-1.60 | 0.150 | 1.19 | 0.91-1.72 | 0.303 | |||
Rs751402 | CC | 366 (38.3) | 371 (36.7) | 0.183 | 0.913 | 1.00 | |||||
CT | 467 (48.8) | 476 (47.0) | 0.95 | 0.78-1.16 | 0.618 | 0.98 | 0.77-1.33 | 0.774 | |||
TT | 123 (12.9) | 165 (16.3) | 0.88 | 0.67-1.15 | 0.341 | 0.90 | 0.61-1.28 | 0.491 | |||
Dominant | 590 (61.7) | 632 (62.5) | 0.95 | 0.79-1.14 | 0.554 | 0.95 | 0.78-1.22 | 0.711 | |||
Recessive | 833 (87.1) | 847 (83.7) | 0.90 | 0.71-1.15 | 0.411 | 0.93 | 0.69-1.18 | 0.487 | |||
Rs2296147 | TT | 599 (62.7) | 640 (63.2) | 0.076 | 0.963 | 1.00 | |||||
CT | 301 (31.5) | 332 (32.9) | 0.97 | 0.80-1.17 | 0.745 | 0.97 | 0.80-1.19 | 0.674 | |||
CC | 56 (5.9) | 40 (3.9) | 1.50 | 0.98-2.28 | 0.059 | 1.40 | 0.97-2.50 | 0.061 | |||
Dominant | 357 (37.3) | 372 (36.8) | 1.03 | 0.85-1.23 | 0.789 | 1.01 | 0.80-1.38 | 0.865 | |||
Recessive | 900 (94.1) | 973 (96.1) | 1.51 | 1.00-2.29 | 0.050 | 1.36 | 0.99-2.49 | 0.053 | |||
Rs1047768 | TT | 505 (52.8) | 540 (53.4) | 0.367 | 0.832 | 1.00 | |||||
CT | 379 (39.6) | 406 (40.1) | 1.00 | 0.83-1.20 | 0.985 | 1.00 | 0.80-1.28 | 0.989 | |||
CC | 72 (7.6) | 66 (6.5) | 1.17 | 0.82-1.66 | 0.395 | 1.11 | 0.79-1.92 | 0.505 | |||
Dominant | 451 (47.2) | 472 (46.6) | 1.02 | 0.86-1.22 | 0.812 | 1.01 | 0.81-1.45 | 0.897 | |||
Recessive | 884 (92.5) | 946 (93.5) | 1.17 | 0.83-1.65 | 0.381 | 1.12 | 0.74-1.84 | 0.561 | |||
Rs873601 | GG | 271 (28.3) | 288 (28.5) | 0.247 | 0.884 | 1.00 | |||||
AG | 475 (49.7) | 514 (50.8) | 0.98 | 0.80-1.21 | 0.865 | 0.99 | 0.63-1.88 | 0.931 | |||
AA | 210 (22.0) | 210 (20.7) | 1.06 | 0.83-1.37 | 0.638 | 1.03 | 0.71-2.01 | 0.807 | |||
Dominant | 685 (71.7) | 724 (71.5) | 1.12 | 0.92-1.37 | 0.245 | 1.07 | 0.82-1.94 | 0.466 | |||
Recessive | 746 (78.0) | 802 (79.2) | 1.08 | 0.87-1.33 | 0.511 | 0.98 | 0.88-1.37 | 0.685 |
Table 3 Genotypes of single nucleotide polymorphism and 5-year survival status of gastric cancer cases
SNP | Genotype | Case | Death (%) | 5-yr survival rate (%) | P-value1 |
Rs2094258 | CC | 388 | 157 (40.5) | 59.4 | 0.032 |
CT | 440 | 203 (46.1) | 53.7 | ||
TT | 123 | 68 (55.3) | 45.4 | ||
Rs751402 | CC | 363 | 162 (44.6) | 55.3 | 0.523 |
CT | 465 | 216 (46.5) | 53.3 | ||
TT | 121 | 50 (41.3) | 58.9 | ||
Rs2296147 | TT | 589 | 281 (47.7) | 52.0 | 0.217 |
CT | 297 | 124 (41.8) | 57.6 | ||
CC | 50 | 23 (46.0) | 57.7 | ||
Rs1047768 | TT | 501 | 243 (48.5) | 51.2 | 0.102 |
CT | 375 | 152 (40.5) | 59.1 | ||
CC | 67 | 33 (49.3) | 53.4 | ||
Rs873601 | GG | 268 | 131 (48.9) | 51.2 | 0.362 |
AG | 472 | 203 (43.0) | 56.8 | ||
AA | 207 | 94 (45.4) | 54.7 |
Table 4 Univariate analysis of associations between influencing factors and 5-year survival of gastric cancer cases
Variable | Classification | n | Death (%) | 5-yr survival rate (%) | P-value1 |
Gender | Male | 667 | 303 (45.4) | 54.2 | 0.399 |
Female | 289 | 125 (43.3) | 56.1 | ||
Age (yr) | ≤60 | 569 | 235 (41.3) | 58.5 | 0.011 |
>60 | 387 | 193 (49.9) | 49.7 | ||
Drinking | No | 758 | 335 (44.2) | 55.6 | 0.259 |
Yes | 198 | 93 (47.0) | 52.9 | ||
Smoking | No | 560 | 244 (43.6) | 55.9 | 0.417 |
Yes | 396 | 184 (46.5) | 53.3 | ||
H. pylori infection | Negative | 281 | 118 (42.0) | 58.1 | 0.284 |
Positive | 675 | 310 (45.9) | 51.4 | ||
TNM stage | I | 178 | 18 (10.1) | 87.7 | <0.001 |
II | 366 | 129 (35.2) | 66.9 | ||
III | 404 | 281 (69.6) | 29.8 | ||
Differentiation | Poor | 661 | 329 (49.8) | 50.0 | <0.001 |
Moderate or high | 280 | 99 (35.4) | 66.7 | ||
Lymphovascular invasion | Negative | 269 | 57 (21.2) | 79.6 | <0.001 |
Positive | 675 | 371 (55.0) | 44.8 | ||
Neural invasion | Negative | 396 | 132 (33.3) | 67.4 | <0.001 |
Positive | 548 | 296 (54.0) | 45.7 | ||
Chemotherapy | No | 361 | 281 (77.8) | 22.9 | <0.001 |
Yes | 592 | 147 (24.8) | 75.1 |
Table 5 Multivariate analysis of gastric cancer survival
Variable | Comparison | HR1 | 95%CI | P-value |
Differentiation | Poor vs Moderate or high | 4.51 | 1.99-8.23 | <0.001 |
Lymphovascular invasion | Positive vs Negative | 1.97 | 1.44-3.01 | <0.001 |
Chemotherapy | Yes vs No | 0.81 | 0.63-0.98 | 0.041 |
Rs2094258 | Increase in C allele | 1.19 | 1.02-1.45 | 0.037 |
- Citation: Wang XQ, Terry PD, Li Y, Zhang Y, Kou WJ, Wang MX. Association of XPG rs2094258 polymorphism with gastric cancer prognosis. World J Gastroenterol 2019; 25(34): 5152-5161
- URL: https://www.wjgnet.com/1007-9327/full/v25/i34/5152.htm
- DOI: https://dx.doi.org/10.3748/wjg.v25.i34.5152