Helicobacter pylori virulence genes

Table 1 Prevalence of oipA “on” status among isolates from various geographical regions

Country	Number of patients	Study population	oipA “on” prevalence	Association with other virulence genes
North-Eastern Brazil[30]	95	Adults with gastritis, GC and their first degree relatives, asymptomatic children	81.1%	cagAvacA s1 m1
Iran[31]	53	Adults and children with chronic gastritis, PUD, intestinal metaplasia and GC	79.0%	cagA, vacA s1 m1
Venezuela[32]	113	Adults with chronic gastritis	83.0%	NA
Bulgaria[33]	70	Symptomatic adults	81.0%	cagA, vacA s1, m1 and m2
Malaysia and Singapore[34]	159	Adults with functional dyspepsia, GC and PUD	89.4%	vacA m1/m2
Italy[35]	90	Adults with chronic gastritis and PUD	77.4%	babA2, hopQ
Colombia and United States[36]	200	Patients with gastritis, PUD and GC	79.3%	cagA, babA
Germany[26]	58	Patients with chronic gastritis	59.0%	cagA, vacA s1, babA
Netherlands[37]	96	Adults with chronic gastritis, PUD, GC and lymphoma	72.0%	cag PAI+
Italy[27]	60	Adults with chronic gastritis, PUD and duodenitis	60.0%	cagA, vacA s1 and m1, babA
East Asia and India[38]	54	Adults with gastritis and PUD	100.0%	cagA, vacA s1
Western countries[38]	55	Adults with gastritis and PUD	63.6%	cagA, vacA s1

NA: Not available; PUD: Peptic ulcer disease; GC: Gastric cancer.

Table 2 Overview of studies on homB prevalence and clinical significance in adults and children

Country	Study population	Number of patients	homB prevalence	Clinical relevance of homB	Association with other virulence genes
Western countries[43]	Adults	234	53.8	Significant, PUD	vacA s1, cagA+
East Asian countries[43]	Adults	138	86.8	NS	NS
Western countries[46]	Adults	300	56.0	NA	NA
East Asian countries[46]	Adults	138	86.6	NA	NA
Burkina Faso[46]	Adults	11	90.9	NA	NA
Colombia, United States[47]	Adults	286	61.2	Significant, GC	cagA+
Iran[45]	Adults	138	43.5	Significant, GC	cagA+
Iraq[48]	NA	70	29.9	NS	NS
Turkey[48]	NA	64	33.9	NS	NS
South Korea[44]	Children and adults	260	69.2	NS	vacA
Portugal[49]	Children	45	58.4	Significant, PUD	NA
	Adults	90	57.7	NS	NA
Portugal[42]	Children	84	57.3	Significant, PUD	cagA+, vacA s1, babA2+, hopQI, oipA “on”
	Adults	106	56.8	Significant only in ≤ 40 yr of age, PUD
Portugal[22]	Children	117	53.5	Significant, PUD	jhp0562
Slovenia[50]	Children	285	40.7	NS	NS

NS: Non-significant; NA: Not available; PUD: Peptic ulcer disease; NUD: Non-ulcer dyspepsia; GC: Gastric cancer.