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©The Author(s) 2019.
World J Gastroenterol. Aug 28, 2019; 25(32): 4764-4778
Published online Aug 28, 2019. doi: 10.3748/wjg.v25.i32.4764
Published online Aug 28, 2019. doi: 10.3748/wjg.v25.i32.4764
Table 1 Demographic and characteristics, n (%)
| Variables | HBeAg-positive(n = 164) | HBeAg-negative(n = 156) | P value |
| Age (median, IQR) (yr) | 39 (14) | 45 (11) | < 0.001 |
| Male | 117 (71) | 100 (64) | 0.166 |
| Platelet counts (Median, IQR) (109/L) | 165.5 (84) | 160 (83) | 0.074 |
| Prothrombin time (Median, IQR) (s) | 12.1 (2.3) | 12.1 (2.5) | 0.574 |
| Alanine transaminase (Median, IQR) (IU/L) | 60.5 (87) | 43 (54) | 0.041 |
| Aspartate aminotransferase (Median, IQR) (IU/L) | 46.5 (49) | 35 (39) | 0.144 |
| Alkaline phosphatase (Median, IQR) (U/L) | 81 (33) | 77.5 (39) | 0.687 |
| γ-glutamyltransferase (Median, IQR) (U/L) | 37 (59) | 31 (36) | 0.134 |
| Albumin (Median, IQR) (g/L) | 42.0 (6.4) | 43.0 (5.9) | 0.014 |
| Globulin (Median, IQR) (g/L) | 30.5 (6.2) | 30.1 (6.1) | 0,239 |
| Cholinesterase (Median, IQR) (U/L) | 6547 (2148) | 7113.5 (2621) | 0.029 |
| Adenosine deaminase (Median, IQR) (U/L) | 16.0(9.9) | 15.8 (10.6) | 0.787 |
| Haptoglobin (Median, IQR) (g/L) | 384 (518) | 401.5 (495) | 0.339 |
| α2-Macroglobulin (Median, IQR) (μg/mL) | 2080 (900) | 2555 (905) | <0.001 |
| Hyaluronic acid (Median, IQR) (μg/L) | 74 (66) | 60 (71) | 0.391 |
| Propeptide of type III procollagen (Median, IQR) (μg/L) | 8 (5) | 7 (3) | 0.375 |
| α-Fetoprotein (Median, IQR) (ng/mL) | 5.1 (9.2) | 4.3 (5.8) | 0.581 |
| Spleen thickness (Median, IQR) (mm) | 35 (7) | 35 (6) | 0.562 |
| Spleen length (Median, IQR) (mm) | 107 (20) | 110.5 (19) | 0.373 |
| HBVDNA (Median, IQR) (log IU/mL) | 7.5 (2.1) | 4.9 (1.8) | < 0.001 |
| quantitative of HBsAg (Median, IQR) (log IU/mL) | 3.9 (1.1) | 3.3 (0.7) | < 0.001 |
| HBcrAg (Median, IQR) (log IU/mL) | 8.0 (2.0) | 4.9 (2.3) | < 0.001 |
| Genotype | |||
| B | 28 (17) | 38 (24) | 0.038 |
| C | 123 (75) | 93 (60) | |
| BCP/PC/C mutation | |||
| T1753C/A/G | 24 (14.6) | 48 (31) | 0.002 |
| T1754G | 2 (1.2) | 12 (7.7) | 0.061 |
| T1758C | 15 (9.1) | 5 (3.2) | 0.135 |
| A1762T | 102 (62.1) | 113 (72.4) | 0.083 |
| G1764A | 102 (62.1) | 119 (76.3) | 0.019 |
| C1766T | 16 (9.8) | 14 (8.9) | 0.789 |
| A1846T/C | 15 (9.1) | 62 (39.7) | < 0.001 |
| G1862T | 5 (3.0) | 10 (6.4) | 0.377 |
| G1896A | 32 (19.7) | 106 (67.9) | < 0.001 |
| G1899A | 6 (3.7) | 36 (23.1) | < 0.001 |
| C1913A/G | 21 (12.90 | 19 (12.2) | 0.909 |
| Ishak Fibrosis Score (mean ± SD) | 4.3 ± 1.2 | 4.7 ± 1.2 | 0.006 |
| S1+ S2 | 14 (8.5) | 15 (9.6) | 0.406 |
| S3 | 48 (29.3) | 36 (23.1) | |
| S4 | 36 (22.0) | 27 (17.3) | |
| S5 | 31 (18.9) | 34 (21.8) | |
| S6 | 35 (21.3) | 44 (28.2) | |
| Knodell necroinflammation (mean ± SD) | 6.8 ± 2.7 | 6.0 ± 3.0 | 0.013 |
| 0-3 | 21 (13) | 36 (23) | 0.046 |
| 4-6 | 52 (32%) | 52 (33) | |
| 7-9 | 68 (41) | 46 (30) | |
| 10-14 | 23 (14) | 22 (14) |
Table 2 Serum hepatitis B core-related antigen level and clinical characteristics, n (%)
| Variables | HBcrAg-high (n = 160) | HBcrAg-low (n = 160) | P value |
| Age (Median, IQR) (yr) | 39 (15) | 44 (12) | < 0.001 |
| Male | 110 (69) | 107 (67) | 0.720 |
| Platelet counts (Median, IQR) (109/L) | 169 (84) | 159.5 (78) | 0.066 |
| Prothrombin time (Median, IQR) (s) | 12.1 (2.6) | 12.0 (2.2) | 0.966 |
| Alanine transaminase (Median, IQR) (IU/L) | 67 (84) | 41 (48) | 0.020 |
| Aspartate aminotransferase (Median, IQR) (IU/L) | 49 (48) | 34 (32) | 0.013 |
| Alkaline phosphatase (Median, IQR) (U/L) | 81 (33) | 77 (37) | 0.454 |
| γ-glutamyltransferase (Median, IQR) (U/L) | 35 (60) | 33 (36) | 0.135 |
| Albumin (Median, IQR) (g/L) | 42.0 (6.4) | 43.0 (5.3) | 0.032 |
| Globulin (Median, IQR) (g/L) | 30.6 (7.0) | 29.0 (5.8) | 0.003 |
| Cholinesterase (Median, IQR) (U/L) | 6438 (2265) | 7133.5 (2327) | 0.065 |
| Adenosine deaminase (Median, IQR) (U/L) | 16.4 (10.0) | 15.2 (9.2) | 0.582 |
| Haptoglobin (Median, IQR) (g/L) | 384 (515) | 391.5 (486.5) | 0.664 |
| α2-Macroglobulin (Median, IQR) (μg/mL) | 2200 (960) | 2480 (990) | 0.003 |
| Hyaluronic acid (Median, IQR) (μg/L) | 74 (66.0) | 63.5 (72.0) | 0.787 |
| Propeptide of type III procollagen (Median, IQR) (μg/L) | 6438 (5.0) | 7 (3.0) | 0.434 |
| α-Fetoprotein (Median, IQR) (ng/mL) | 5.0 (9.1) | 4.7 (6.5) | 0.597 |
| Spleen thickness (Median, IQR) (mm) | 35 (7.0) | 35 (5.0) | 0.239 |
| Spleen length (Median, IQR) (mm) | 109 (21.0) | 109 (18.0) | 0.410 |
| HBVDNA (Median, IQR) (log IU/mL) | 7.5 (2.0) | 4.9 (1.8) | < 0.001 |
| quantitative of HBsAg (Median, IQR) (log IU/mL) | 3.9 (1.2) | 3.3 (0.7) | < 0.001 |
| Genotype | |||
| B | 35 (22) | 31 (19) | 0.971 |
| C | 114 (71) | 102 (64) | |
| BCP/PC/C mutation | |||
| T1753C/A/G | 18 (11.3) | 54 (33.8) | < 0.001 |
| T1754G | 5 (3.1%) | 8 (5.0) | 0.602 |
| T1758C | 11 (6.9) | 10 (6.3) | 0.792 |
| A1762T | 92 (57.5) | 124 (77.5) | 0.001 |
| G1764A | 96 (60.0) | 125 (78.1) | 0.002 |
| C1766T | 7 (4.4) | 24 (15.0) | 0.006 |
| A1846T/C | 16 (10.0) | 61 (38.1) | < 0.001 |
| G1862T | 5 (3.1) | 10 (6.3%) | 0.256 |
| G1896A | 42 (26.3) | 96 (60.0) | < 0.001 |
| G1899A | 7 (4.4) | 35 (21.9) | < 0.001 |
| C1913A/G | 18 (11.3) | 22 (13.8) | 0.577 |
| HBeAg-positive | 131 (79.9) | 33 (21.2) | < 0.001 |
| Ishak Fibrosis Score (mean ± SD) | 4.2 ± 1.1 | 4.8 ± 1.1 | < 0.001 |
| Knodell Necroinflammation Score (mean ± SD) | 6.9 ± 2.7 | 5.8 ± 2.9 | 0.001 |
- Citation: Chang XJ, Sun C, Chen Y, Li XD, Yu ZJ, Dong Z, Bai WL, Wang XD, Li ZQ, Chen D, Du WJ, Liao H, Jiang QY, Sun LJ, Li YY, Zhang CH, Xu DP, Chen YP, Li Q, Yang YP. On-treatment monitoring of liver fibrosis with serum hepatitis B core-related antigen in chronic hepatitis B. World J Gastroenterol 2019; 25(32): 4764-4778
- URL: https://www.wjgnet.com/1007-9327/full/v25/i32/4764.htm
- DOI: https://dx.doi.org/10.3748/wjg.v25.i32.4764