Retrospective Study
Copyright ©The Author(s) 2019.
World J Gastroenterol. Aug 28, 2019; 25(32): 4739-4748
Published online Aug 28, 2019. doi: 10.3748/wjg.v25.i32.4739
Table 1 Characteristics of enrolled patients
CharacteristicNumber
Total number of enrolled patients42
Age (mean ± SD, yr)47.15 ± 15.91
Gender, n (%)
Male27 (64.29)
Female15 (35.71)
BMI26.67 ± 4.30
Etiology of SAP
Biliary tract disease20
Alcoholism8
Hypertriglyceridemia7
Drug-induced0
Others7
Number of failed organs
112
29
≥ 37
Mortality at 90 d, n (%)18 (42.86)
Table 2 Demographic parameters between the survival and non-survival groups
Demographic parameterSurvival groupNon-survival groupP-value
Number2220
Age (yr)50.50 ± 17.7844.33 ± 13.280.206
GenderMale (12): female (10)Male (15): female (5)0.720
BMI (kg/m2)26.72 ± 4.6126.59 ± 3.960.924
LOS-ICU (d)7.71 ± 6.6411.22 ± 14.400.347
RDW-CV (%)13.59 ± 0.8815.09 ± 1.630.002
RDW-SD (fL)43.96 ± 3.1149.94 ± 5.510.000
PDW (fL)14.72 ± 3.3514.95 ± 3.760.842
CRP (mg/L)212.10 ± 107.04212.19 ± 144.970.998
NLR14.05 ± 10.139.92 ± 4.530.085
Serum calcium1.64 ± 0.271.77 ± 0.450.253
APACHE II12.42 ± 4.2715.67 ± 5.700.041
SOFA4.83 ± 2.657.94 ± 2.990.001
Table 3 Correlation of red blood cell distribution width with Acute Physiology and Chronic Health Evaluation II score and Sequential Organ Failure Assessment score
VariableRDW-CV
RDW-SD
rP-valuerP-value
APACHE II0.5040.0010.4340.004
SOFA0.4140.0060.3800.012
Mortality0.5040.0010.4900.001
Table 4 Parameters of receiver operating characteristic curves
ParameterAUCSDP-value95% confidence interval
Lower limitUpper limit
RDW-CV0.7970.0690.001b0.6620.933
RDW-SD0.8110.0710.001d0.6730.950
APACHE II0.6770.0890.0520.5040.851
SOFA0.7850.0710.002f0.6460.924
Table 5 Cut-off values for red blood cell distribution width
ParameterSensitivitySpecificityYouden index
RDW-CV13.450.8890.6250.514
13.550.8330.6670.500
13.350.8890.5830.472
13.650.7780.6670.445
RDW-SD50.50.55610.556
51.50.510.500
45.50.7780.7080.486
49.50.5560.9170.473
Table 6 Independent predictors of severe acute pancreatitis in a multivariate logistic regression analysis
VariableMultivariate OR (95%CI)P-value
RDW-CV3.283 (1.503-7.174)0.003
RDW-SD1.368 (1.120-1.670)0.002
APACHE II1.172 (1.017-1.351)0.028
SOFA1.682 (1.212-2.332)0.002
Table 7 Univariate Cox proportional hazards regression analysis (P = 0.001 for trend)
VariableMultivariate OR (95%CI)P-value
RDW-CV1.615 (1.258-2.072)0.000
RDW-SD1.166 (1.077-1.261)0.000
RDW-CV and RDW-SD1.005 (1.003-1.008)0.000
APACHE II1.151 (1.048-1.264)0.003
SOFA1.363 (1.175-1.582)0.000